Building a Baby from the Foundation Upwards:

                                Building a Baby from the Foundation Upwards:

Neurological Issues Can Start From Conception If the Conditions Are Right

 

 Genetics, nutrition, environmental toxins, vaccines, and their combined impact on the immune system, can all play a role in Autism spectrum disorders. Think of it as a pyramid with the child at the top and all the damaging features underneath starting in utero. Some children don’t need vaccines to tip them over the edge if the child was born at the top or near the top of the pyramid to begin with. Other children who are close to the top, all they would need is a major mineral imbalance combined with one or two vaccines to tip them over the edge.

Think about this quote in the United States Senate on May 12, 1999 by Dr. Bonnie Dunbar, a Professor of Immunobiology:

“I would challenge any colleague, clinician or research scientist to claim that we have a basic understanding of the human newborn immune system. It is well established in studies in animal models that the newborn immune system is very distinct from the adolescent or adult. In fact, the immune system of newborns in animal models can easily be perturbed to ensure that it cannot respond properly later in life.”

 

Children who have gone into an immediate regressive autism after vaccines are the ones who may have been able to cope, and not tipped over the edge, if they had more time to mature their immature immune systems.  Others, without vaccines, were just too close to the top of the pyramid at birth or in utero.

 

Birth Control Pill Use:

 

Anything that affects hormones enough to stop a lining shedding could cause issues. The use of hormones disrupts mineral balance, and further disturbs the normal running of metabolic pathways. If enough are disturbed, then it could contribute to an unstable foundation for a baby. The pill can strip out magnesium, zinc, B6, folic acid and EFA’s from the body.

The pill can skew the hormone system long-term and changes vascular circulation permanently, and further trashes the body’s supply of magnesium, zinc, B vitamins, folic acid and essential fatty acids. All these things lay the foundation for a pregnancy in which fetal nutrient absorption comes from a deficit position right at the outset.

Dr. Ellen Grant wrote a book called Sexual Chemistry which explains it. She was involved in the original large trials on what the pill does to the body.

 Also:  

…”Our studies in 1981 and 1989 found significantly higher concentrations of copper and cadmium in hair in dyslexic children compared with matched controls.1,2 Sweat zinc was severely deficient in the dyslexic children, being 66% lower than that for control children. However, the control children in 1989 had much lower average zinc level than the children tested for laboratory reference range purposes 10 years before in 1979.2,3 Zinc deficiency allows accumulation of toxic metals which may be important causes of the increase in autism, asthma, dyslexia and hyperactivity in the past few decades.4,5

Biolab Medical Unit offers analyses of all toxic metal levels in blood, metal sensitivity tests and the effects of toxic metal substitution on proteins and some binding sites.6,7 Dr John McLaren- Howard presented the results of testing 61 autistic children at a Biolab Workshop for Doctors in June 2004, as he was attempting to find out which nutritional tests should be recommended. Among the 42 boys and 19 girls most were deficient in zinc and magnesium. Many were also deficient in copper, chromium, manganese, molybdenum and B vitamins. Therefore, essential fatty acids were also likely to be deficient. 16 children had DNA-adducts in leucocytes to malondialdehyde, 12 to cadmium, 9 to nickel. Three of the 61 children had DNA-adducts to mercury and one had DNA- adducts to lead. 37 children had antigliadin IgG antibodies, while 30 children had malabsorption detected by a D-xylose test. Malabsorption was most common in those with Asperger’s type syndrome, 16 out of 18 children.

The zinc and magnesium lowering effects of maternal use of progesterones and oestrogens, parental smoking and alcohol use and parental dental mercury and other dental metal levels like nickel and tin, need to be looked at in larger studies. Mercury is a toxic metal whether it is in dental amalgams or in vaccines. If 5% of autistic children show evidence of signs of mercury exposures, this still means large numbers of children have been adversely affected. Clearly the increasing incidence of childhood diseases needs proper biochemical scientific investigations.”

  
Environmental:

 

Pollutants ‘in children’s blood’  

Toxic metals for vegetable fruit sprays, like Arsenate of copper and Arsenate of Mercury, DDT used to be used. Now, sprays are different, but are they really better? Our stolen future  and Chem Trails.  

 

Vaccines:

 

The vaccine becomes the bullet for many children. They start out seemingly healthy, even with perhaps a shaky foundation. But once the bullet (vaccine) is injected, they begin to spiral downwards. Symptoms are pathway dysfunction, not illness.

 

Diet and Nutrition/Minerals:

 

Copper and zinc are important because if they are out of sync the enzymes that create neurotransmitters, that the brain cells use to transmit their messages from one brain cell to another, won’t work properly. B6 works with those. Proper balance is what is needed because if you get the copper and zinc right, you can modulate the brains regulation of mood and reaction to stress. These enzymes also need B6; as B6 often helps in treating depression. In women, low zinc and high copper can be linked to ‘rage’ episodes during PMS.

Suphur has a key interaction with selenium. Selenium is good for skin, hair, nails, to build certain amino acids in the cells and brain, and make sulfonated compounds for the joints.  When there is a deficiency, there is a reduction in the activity of the enzyme gluthathione peroxidase. This results in reduced immune function, which has its greatest effect on the helper T dependent cells,  and production of Ig.M is impaired. IgM is one of the front line Th1 antibodies which are made in the early stages of an infection. Children suffering from malnutrition fail to grow when given a recuperative diet, if it remains selenium deficient because selenium is necessary for protein synthesis. While it protects against the toxic effects of the pollutant cadmium, and mercury from all sources, it also increases the effectiveness of vitamin E, and it reduces the chances of all types of cancer. In communities where selenium intake is low, the cancer rate is high.

Maternal selenium nutrition and neonatal immune system development.

Skeletal muscle disorders associated with selenium deficiency in humans.
Deficiency in selenium or Vitamin E also shows reduced natural killer cell activity. With regard to the enzymes; Glutathione is essential for:
-detoxification and liver function
-effective immune response
-antioxidant defense
-male fertility (low sperm counts)

-blood sugar metabolism
-blood pressure regulation
-tumor inhibition
-inhibition of thrombus formation in diabetes
-prevention of neurodegenerative disorders like Alzheimer’s disease, Parkinson disease, Huntington’s chorea, stroke and brain trauma.

Effective Glutathione is important for T cell proliferation, development of large CD8+ T cells, cytotoxic T cell activity and production of CD16+ natural killer cells. Glutathione protects and repairs liver tissue under severe acute and chronic alcohol exposure.

Selenium protects against the toxic effects of the pollutants cadmium, and mercury. It helps prevent chromosome breakage in tissue culture. It is the basis of the unique enzyme system Glutathione peroxidase, which destroys peroxides before they can attack cellular membranes, while the vitamin E acts within the membrane itself preventing the oxidation of membrane lipids.

When discussing epigenetics; they know demethylation is carried down through the generations and they know it can be reversed.

 This is the list of tests a DAN doctor may perform:

*Complete blood count w/ differential and platelet count
*Serum metabolic assay (complete)
*Thyroid profile (T3, T4 and TSH)
*Amino acid profile (plasma)
*Organic acid profile (urine)
*Ammonia level
*Lactic acid level
*Pyruvic acid level (pyruvate)
*Heavy metal profile (lead, mercury, arsenic and cadmium), blood
*Vitamin A level
*Zinc and copper (serum)
*Measles, mumps and rubella antibody IGG titers
*Fragile X
*IgG, A, M, E
*IGG subclasses
*T cell function tests
*Myelin basic protein and neural axon filament antibodies

 But other minerals should be tested as well such as:

*Magnesium

*Chromium

*Selenium

*Aluminum

*Dysbiosis  

 

Immunologist have begun to test for a genetic variant in an enzyme called  Methylenetetrahydrofolate reductase (MTHFR) and  Glutathione.  
METALLOTHIONINE PROTEIN DYSFUNCTION
Diseases that can occur because of MT protein dysfunction include:
· Psoriasis and eczema
· ADD and ADHD
· Autism
· Schizophrenia and Obsessive Compulsive disorder
· Anorexia
· Alcoholism
· Chronic fatigue syndrome
· Alzheimer’s

Metallothionine protein disorder is thought to be a genetic defect involving more than one gene. This disorder results in a decreased ability of the MT protein to function normally. Metallothionine protein helps regulate zinc and copper levels in the blood,  withdrawal heavy metals as they enter the body, help development and continued functioning of the immune system, help development and pruning of brain cells, (neurons), help prevent  yeast overgrowth in the intestines, aid in the production of enzymes that break down casein and gluten, aid in the production of hydrochloric acid by stomach cells, help taste and texture discrimination by the tongue, and aid in the behavior control and development of memory and social skills.

In 2000, William Walsh, Ph.D. of the Pfeiffer Treatment Center discovered that the majority of autistic patient’s exhibit MT dysfunction and the classic signs of autism can be explained by a MT dysfunction. There are four primary types of MT proteins and each has an important role in the body.

MT-I and II are present in all cells throughout the body. They regulate copper and zinc, are involved in cell transcription, detoxify heavy metals, play a role in the immune function, and are involved in a variety of G.I. tract functions.

MT-III is found primarily in the brain and functions as a gross inhibitory factor in the brain. MT-III is located primarily in the central nervous system with small amounts present in the pancreas and intestines. It plays a major role in the development, organization and programmed death of brain cells.

MT-IV is found in the skin and upper G.I. tract. They help regulate stomach acid pH, taste and texture discrimination of the tongue and help protect against sunburn and other skin traumas.

Theories for the Pathophysiology of Autism:

Brain autoimmunity
Deficits in sulfur metabolism
Abnormal liver detoxification
Gastrointestinal abnormalities

 

Possible Causes of Immune Injury or Alterations:
 
 

 

A genetic weakness (C4B null allele) and/or predisposition, combined with one or more of the following:
1) Shortened or absent breast-feeding preventing the full development of transferred cellular immunity. (Fudenberg)

2) Early gluten (usually wheat) introduction prior to one year of age. Wheat has been genetically manipulated in the last 100 years to increase the gluten content.

3) Early use of cow’s milk or casein based formulas. (Allergenic and altered)

4) Immunizations with live viruses, especially the MMR after 1978. There is frequent regression after the MMR vaccine that has been observed and published (Wakefield). Other vaccinations and the resulting effects on interleukin or autoimmunity. (Singh) DPT (especially if whole cell pertussis is used) and HepB (not live viruses) may also play a role in immune alterations.

5) Use of antibiotics and resulting yeast and pathogenic bacteria infection or overgrowth, with resulting immune modification and toxic exposure. (Shaw, Fudenberg, Wuepper)

6) Maternal allergy, chronic fatigue syndrome, or leaky gut problems that caused the child to be pre-sensitized in the womb. (Fudenberg)

7) Leaky gut from any number of the above or also related to parasites or GI infections in the child that allow gluten and casein to leak into the bloodstream. Once in the body, the body alters them into toxic substances. Sucrose (table sugar) also leaks in and it is an abnormal sugar in the blood stream that causes a host of problems.

8) Defect in the detoxification pathway of the brain, Phenol Sulfur-Transferase or PST enzyme defect. Inadequate intake of sulfur compounds. (Rosemary Waring, Birmingham University, England).

9) They develop autoantibodies to Myelin Basic Protein (Singh, Fudenberg, and Gupta) and other brain components. Measles is known to induce MBP antibodies. I’ll talk about this a lot more later.

10) Defective cellular immunity, especially in the NK cell activity towards self and pathogens. (Fudenberg, Gupta). And the probable elevation of Interleukin-2 and 12.

 

Jeff Bradstreet, M.D., FAAFP
The International Child Development Resource Center  
Let’s break each one above down…

1. Breast milk creates the right probiotics which absorb minerals the right way, and provide the foundation for cellular immunity and nutrient absorption. The gut makes up 70 % of the immune system.  It also plays a role in e-coli endotoxin production.

2. It has nothing to do with the gluten. Salivary fluid has an enzyme in it, to break down grains when the molar teeth cut. Celiac for example isn’t caused by too much gluten. It’s caused by lack of the enzyme opening the pathway to those with epigenetic susceptibility. Before 1900’s, celiac was pretty much unheard of. More gluten isn’t good for some people.

3. Unpasteurized animal milk worked well versus pasteurized.

4.  True, but you only know what you have looked at. What about the others?

5.  Antibiotics cause immune modification all on their own, not necessarily as a result of the resulting yeast and pathogenic bacteria infection and overgrowth. What about e.coli?

6.  What caused the maternal allergy? If you look at minerals and other, you may be able to eliminate the allergy.

7.  Leaky gut would not be a problem if the foundation was laid right and a change in nutrition better understood.

8.  If you have an inadequate intake of sulfur compounds and/or an inadequate intake of other minerals such as magnesium, zinc, selenium.

9.  That is not the cause, but the end result. The cause needs to be worked out.

10.  See # 9.

Fever Reducers
Fever reducers lower glutathione levels. When glutathione levels are reduced, you increase the level of the hormones. They also suppress the immune system further.

 Also See:

 Autism – the vaccine connection 
  
The lutein free diet, a treatment option for autism. Review of lutein as it relates to autism. 
 
The Thoughtful House (2005 Conference)

 

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