MSG

MSG in Vaccines

 MSG is found in vaccines and it is used as a stabilizer which is an ingredient to keep the virus alive. Essentially, all viral vaccines have free glutamic acid because it is used to feed the live virus. Stabilizers are also added to stabilize the vaccine against temperature variations or a freeze-drying process.

Since we already know the blood brain barrier is not fully developed in young children, to protect the brain against toxins that enter the blood, glutamic acid can penetrate the placental barrier.

 

 Vaccines that contain MSG are:

 

Varivax or otherwise known as the Chicken Pox vaccine. This vaccine contains L-monosodium glutamate and hydrolyzed gelatin.

 

Measles, Mumps, and Rubella (M-M-R) vaccine. The growth medium for Measles and Mumps contains amino acids and glutamate.  The medium for Rubella includes amino acids and hydrolyzed gelatin.  According to the package insert the reconstituted vaccine for subcutaneous administration includes hydrolyzed gelatin.

 

 M-R Vaccine (Measles and Rubella) contains hydrolyzed gelatin.
Attenuvax (Measles) hydrolyzed gelatin.

Biavax (Rubella) hydrolyzed gelatin.

JE-VAX (Japanese Encephalitis) gelatin.

Prevnar ( Pneumococcal– 7 Valent Conjugate Vaccine) soy protein, yeast.

YF-VAX (Yellow Fever ) gelatin.

 FluMist Vaccine (nasal) monosodium glutamate.

 

 Keep in mind that amino acids such as glutamic acid, aspartic acid, and L-cysteine are all neurotoxins.  All hydrolyzed proteins, such as the hydrolyzed gelatin, contain some processed free glutamic acid (MSG), aspartic acid, and L-cysteine. Gelatin and any ingredients that use ‘Hydrolyzed’ contain Glutamate.

  

Risks of FluMist Vaccine
By Dr. Sherri Tenpenny

 

“… The risk that the vaccine may contain contaminant avian retroviruses still remains. In addition, a stabilizing buffer containing potassium phosphate, sucrose (table sugar) and nearly 0.5 mg of monosodium glutamate (MSG) is added to each dose.

 

“One of the most troubling concerns over the injection of this “chemical soup” is the potential for the viruses to enter directly into the brain. At the top of the nasal passages is a paper-thin bone called the cribriform plate. The olfactory nerves pass through this bone and line the nasal passages, carrying messenger molecules to the brain that are identified as “smells” familiar to us. The olfactory tract has long been recognized as a direct pathway to the brain. Intranasal injection of certain viruses has resulted in a serious brain infection called encephalitis, presumably by direct infection of the olfactory neurons that carried the viruses to the brain. [19] Time will tell whether the live viruses in FluMist will become linked to cases of encephalitis.”

 

 Registry of Toxic Effects of Chemical Substances lists glutamic acid as a toxin:

The Registry of Toxic Effects of Chemical Substances Glutamic acid, monosodium salt, L – (+) – RTECS #: MA1575000, CAS #: 142-47-2 can be found here.

CDC: Better Tracking of Hib Needed

CDC: Better Tracking of Hib Needed

haemophilus_influenzae_cdc

Federal health officials are urging doctors and state agencies to be more careful in suspected cases of invasive Haemophilus influenzae type B (HiB) in children younger than 5, largely due to a continuing vaccine shortage that is expected to continue until the middle of 2009.

The vaccine protects against Hib disease (Haemophilus influenza type b) a bacterium estimated to be responsible for some three million serious illnesses and an estimated 386,000 deaths every year, mainly through meningitis and pneumonia.

There are varying forms of serotypes of H. influenzae, says Michael Jackson, an epidemiologist with the U.S. Centers for Disease Control and Prevention (CDC). The current vaccine helps to prevent type B, at one time the most common cause of bacterial meningitis in children.

But the reporting of serotypes to the CDC has been inconsistent with an estimated 40 percent of cases lacking such information, Dr. Jackson said.

“Without the serotype,” says Dr. Jackson, “we are unable to know if it’s type B, which is the type we are most concerned about, or another type that is less worrisome.”

The vaccine shortage began in December 2007 when Merck recalled 1.2 million doses of the vaccine. The voluntary recall began after the Merck found a bacterial contamination, Bacillus cereus on vaccine manufacturing equipment at its Pennsylvania plant.

The company has recently modified its manufacturing process, delaying vaccine availability until the middle of next year, said a spokeswoman for Merck.

While there is enough Hib vaccine to supply infants with a first series of shots, the shortage means children are going longer without the booster shots usually given after their first birthday, said CDC officials.

Agency officials encourage state and hospital laboratories, health departments and doctors to do serotyping of blood or spinal fluid specimens in a timely manner and report findings to the CDC.

The full report is published in the CDC’s weekly MMWR report on November 21, 2008.

How Vaccinations Work

guinea-pigHow Vaccinations Work

 

PHILIP F. INCAO, M.D. May 5, 1999

In order to use vaccinations wisely, we need to understand exactly how they work. Until recently, the “mechanism of action” of vaccinations was always understood to be simply that they cause an increase in antibody levels (titers) against a specific disease antigen (bacterium or virus), thus preventing “infection” with that bacterial or viral antigen.

In recent years science has learned that the human immune system is much more complicated than we thought. It is composed of two functional branches or compartments which may work together in a mutually cooperative way or in a mutually antagonistic way depending on the health of the individual.

One branch is the humoral immune system (or Th2 function) which primarily produces antibodies in the blood circulation as a sensing or recognizing function of the immune system to the presence of foreign antigens in the body. The other branch is the cellular or cell-mediated immune system (or Th1 function) which primarily destroys, digests and expels foreign antigens out of the body through the activity of its cells found in the thymus, tonsils, adenoids, spleen, lymph nodes and lymph system throughout the body. This process of destroying, digesting and discharging foreign antigens from the body is known as “the acute inflammatory response” and is often accompanied by the classic signs of inflammation: fever, pain, malaise and discharge of mucus, pus, skin rash or diarrhea.

These two functional branches of the immune system may be compared to the two functions in eating: tasting and recognizing the food on the one hand, and digesting the food and eliminating the food waste on the other hand. In the same way, the humoral or Th2 branch of the immune system “tastes” and recognizes and even remembers foreign antigens and the cellular or Th1 branch of the immune system digests and eliminates the foreign antigens from the body. But just as too much repeated tasting of food will ruin the appetite, so also too much repeated stimulation of the “tasting” humoral immune system by an antigen will inhibit and suppress the digesting and eliminating function of the cellular immune system. In other words, overstimulating antibody production can suppress the acute inflammatory response of the cellular immune system! 1

This explains the polar opposite relationship between acute discharging inflammations on the one hand and allergies and auto-immune inflammations on the other hand. The more a person has of one, the less he or she will have of the other!

A growing number of scientists believe that the increase in America, Europe, Australia and Japan in allergic and auto-immune diseases (which stimulate the humoral or Th2 branch of the immune system) is caused by the lack of stimulation of the cellular or the Th1 branch of the immune system from the lack of acute inflammatory responses and discharges in childhood. 2 3 4 5 We need to identify the factors which cause this shift in the function of the immune system or which cause allergies and auto-immune diseases in childhood to increase!

If we now return to the original question of the mechanism of action of vaccinations, we find what I believe is the key to the puzzle. A vaccination consists of introducing a disease agent or disease antigen into an individual’s body without causing the disease. If the disease agent provoked the whole immune system into action it would cause all the symptoms of the disease! The symptoms of a disease are primarily the symptoms (fever, pain, malaise, loss of function) of the acute inflammatory response to the disease.

So the trick of a vaccination is to stimulate the immune system just enough so that it makes antibodies and “remembers” the disease antigen but not so much that it provokes an acute inflammatory response by the cellular immune system and makes us sick with the disease we’re trying to prevent! Thus a vaccination works by stimulating very much the antibody production (Th2) and by stimulating very little or not at all the digesting and discharging function of the cellular immune system (Th1).

Vaccine antigens are designed to be “unprovocative” or “indigestible” for the cellular immune system (Th1) and highly stimulating for the antibody-mediated humoral immune system (Th2).

Perhaps it is not difficult to see then why the repeated use of vaccinations would tend to shift the functional balance of the immune system toward the antibody-producing side (Th2) and away from the acute inflammatory discharging side (the cell-mediated side or Th1). This has been confirmed by observation especially in the case of Gulf War Illness: most vaccinations cause a shift in immune function from the Th1 side (acute inflammatory discharging response) to the Th2 side (chronic auto-immune or allergic response). 6

The outcome of this line of thought is that, contrary to previous belief, vaccinations do not strengthen or “boost” the whole immune system. Instead vaccinations overstimulate the “tasting and remembering” function of the antibody-mediated branch of the immune system (Th2) which simultaneously suppresses the cellular immune system (Th1) thus “preventing” the disease in question.

What in reality is prevented is not the disease but the ability of our cellular immune system to manifest, to respond to and to overcome the disease!

There is no system of the human being, from mind to muscles to immune system, which gets stronger through avoiding challenges, but only through overcoming challenges. The wise use of vaccinations would be to use them selectively, and not on a mass scale. In order for vaccinations to be helpful and not harmful, we must know beforehand in each individual to be vaccinated whether the Th1 function or the Th2 function of the immune system predominates.

In individuals in whom the Th1 function predominates, causing many acute inflammations because the cellular immune system is overreactive, a vaccination could have a balancing effect on the immune system and be helpful for that individual.

In individuals in whom the Th2 function predominates, causing few acute inflammations but rather the tendency to chronic allergic or autoimmune inflammations, a vaccination would cause the Th2 function to predominate even more, aggravating the imbalance of the immune system and harming the health of that individual. This is what happened in Gulf War Illness.

The current use of vaccinations in medicine today is essentially a “shotgun” approach which ignores differences among individuals. In such an approach some individuals may be helped and others may be harmed.

If medicine is to evolve in a healthy direction, we must learn to understand the particular characteristics of each individual and we must learn how to individualize our treatments to be able to heal each unique human being in our care.

Based on the preceding explanation of how vaccinations work, here are my answers to your questions:

Vaccinations are usually effective in preventing an individual from manifesting a particular illness, but they do not improve the overall strength or health of the individual nor of the immune system. Instead, vaccinations modify the reactivity of the immune system, decreasing acute discharging inflammatory reactions and increasing the tendency to chronic allergic and auto-immune reactions.

Epidemiologic studies 7 8 9 have shown that as families improve their living conditions, hygiene, nutrition, literacy and education, the risk of life-threatening acute infectious , inflammatory diseases very much decreases. Families with poor living conditions, hygiene, nutrition and literacy would generally be most likely to benefit from vaccinations. Families with good living conditions, hygiene, nutrition and education probably would benefit from vaccinations very little or not at all. Individuals with a tendency to allergic or auto-immune diseases are likely to be harmed by vaccinations.

Side effects of vaccination are usually allergic or auto-immune inflammatory reactions caused by the shift of the immune system’s reactivity from the Th1 side to the Th2 side. Modern medicine is just beginning to recognize this. 10

Modern medicine has not scientifically measured the risk/benefit ratio of any vaccine. 11 Research into the risks of vaccines is very inadequate, according to two comprehensive reports on vaccines by the U.S. Institute of Medicine in 1991 and 1994.

My preceding explanation of how vaccinations affect the immune system is true also in animals. Vaccinations cannot make animals healthier, but only good handling, environment and nutrition can make animals healthy and resistant to disease. Vaccinating pigs may prevent them from having illness from one particular strain of virus but will not improve their overall resistance to other illnesses nor even to other strains of the same virus.

It is important to remember that an infection with a particular virus or bacterium does not necessarily cause illness unless the resistance of the individual is low. In the case of Japanese Encephalitis Virus (JEV), most infections cause no symptoms and fewer than 0.1% of infected individuals develop severe encephalitis. 12 Individuals living in poor conditions, with poor hygiene, nutrition and education are at higher risk of serious illnesses from JEV or any other infection. In such individuals a vaccination would most likely be helpful.

Each individual should inform himself or herself: just how widespread is the disease outbreak? How many have become seriously ill or died? Does the outbreak affect all levels of society or mainly those in poor living conditions?

Very often the media exaggerate the extent of such outbreaks. Each individual should freely decide, based on knowledge and not on fear and hearsay, whether he or she or a child would benefit from a vaccination.

 

1 Parish, C.R. “The Relationship Between Humoral and Cell-Mediated Immunity.” Transplant. Rev. 13 (1972):3.

2 Ronne, T. “Measles Virus Infection without Rash in Childhood is Related to Disease in Adult Life.” The Lancet Ltd. (1985):1-5.

3 Odent, M.R., Culpin, E.E., Kimmel, T. “Pertussis Vaccination and Asthma: Is There a Link The Journal of the American Medical Association 272(1994):588.

4 Cookson, W.O.C.M., and Moffatt, M.F. “Asthma: An Epidemic in the Absence of Infection?” Science 275(1997):41-42.

5 Martinez, F.D. Role of viral infections in the inception of asthma and allergies during childhood: could they be protective? Thorax 1994;49: 1189-91.

6 Rook, G.A.W., Zumla, A. “Gulf War Syndrome: Is It Due to a Systemic Shift in Cytokine Balance Towards a Th2 Profile?” The Lancet 349 (1997): 1831-1833.

7 McKeown, T. The Modern Rise of Population. New York: Academic Press, 1976.

8 McKeown, T. The Role Of Medicine: Dream, Mirage, or Nemesis? New Jersey: Princeton University Press 1979.

9 Sagan, L.A. The Health of Nations. New York: Basic Books, Inc., 1987.

10 Rook, G.A.W., Zumla, A. “Gulf War Syndrome: Is It Due to a Systemic Shift in Cytokine Balance Towards a Th2 Profile?” The Lancet 349 (1997): 1831-1833.

11 Robin, Eugene, M.D. “Some Hidden Dimensions of the Risk/Benefit Value of Vaccine” from the First International Public Conference on Vaccination. Alexandria, Virginia September 1997.

12 Solomon, T., Kneen, R., Dung, N.G., Khanh, V.C., Thuy, T.T.N., Ha, D.Q., Day, N.P.J., Nisalak, A., Vaughn, D.W., White, N.J. “Poliomyelitis-like illness due to Japanese encephalitis virus” Lancet 1998; 351: 1094-97

Trace Melamine Found In Popular U.S. Baby Formulas

Trace Melamine Found In Popular U.S. Baby Formulas

…Previously undisclosed tests, obtained by The Associated Press under the Freedom of Information Act, show that the FDA has detected melamine in a sample of one popular formula and the presence of cyanuric acid, a chemical relative of melamine, in the formula of a second manufacturer.

Separately, a third major formula maker told AP that in-house tests had detected trace levels of melamine in its infant formula.

The three firms – Abbott Laboratories, Nestle and Mead Johnson – manufacture more than 90 percent of all infant formula produced in the United States.

The FDA and other experts said the melamine contamination in U.S.-made formula had occurred during the manufacturing process, rather than intentionally.

The U.S. government quietly began testing domestically produced infant formula in September, soon after problems with melamine-spiked formula surfaced in China.

…FDA scientists said then that they couldn’t set an acceptable level of melamine exposure in infant formula because science hadn’t had enough time to understand the chemical’s effects on infants’ underdeveloped kidneys. Plus, there is the complicating factor that infant formula often constitutes a newborn’s entire diet.

…The Grocery Manufacturers Association, for example, told its members: “FDA could not identify a safe level for melamine and related compounds in infant formula; thus it can be concluded they will not accept any detectable melamine in infant formula.”

It was not until the AP inquired about tests on domestic formula that the FDA articulated that while it couldn’t set a safe exposure for infants, it would accept some melamine in formula – raising the question of whether the decision to accept very low concentrations was made only after traces were detected.

…According to FDA data for tests of 77 infant formula samples, a trace concentration of melamine was detected in one product – Mead Johnson’s Infant Formula Powder, Enfamil LIPIL with Iron. An FDA spreadsheet shows two tests were conducted on the Enfamil, with readings of 0.137 and 0.14 parts per million.

Three tests of Nestle’s Good Start Supreme Infant Formula with Iron detected an average of 0.247 parts per million of cyanuric acid, a melamine byproduct.

The FDA said last month that the toxicity of cyanuric acid is under study, but that meanwhile it is “prudent” to assume that its potency is equal to that of melamine.

And while the FDA said tests of 18 samples of formula made by Abbott Laboratories, including its Similac brand, did not detect melamine, spokesman Colin McBean said some company tests did find the chemical. He did not identify the specific product or the number of positive tests.

…Mead Johnson spokeswoman Gail Wood said her company’s in-house tests had not detected any melamine, and that the company had not been informed of the FDA test results, even during a confidential agency conference call Monday with infant formula makers about melamine contamination.

The FDA tests also detected melamine in two samples of nutritional supplements for very sick children who have trouble digesting regular food. Nestle’s Peptamen Junior medical food showed 0.201 and 0.206 parts per million of melamine while Nestle’s Nutren Junior-Fiber showed 0.16 and 0.184 parts per million.

The agency said that while there are no established exposure levels for infant formula, pediatric medical food – often used in feeding tubes for very sick, young children – can have 2.5 parts per million of melamine, just like food products other than infant formula.

The head of manufacturing for Nestle Nutrition in North America, Walter Huber, said in an interview that the company took samples alongside FDA officials who visited a manufacturing plant, and that those samples showed similar results to what FDA found for the two pediatric medical foods. Huber added that Nestle didn’t fund cyanuric acid in any of the samples.

AAP Doubles Vitamin D Recommendation

AAP Doubles Vitamin D Recommendation

All children should get at least 400 IU of vitamin D daily, either through dietary intake or supplementation, beginning within days of birth and continuing through adolescence, according to new guidelines from the American Academy of Pediatrics.

This advice doubles the organization’s previous vitamin D intake recommendation in an effort to prevent the development of rickets in specific pediatric populations, as well as to take advantage of the potential long-term health benefits associated with adequate intake of the fat-soluble nutrient, Dr. Frank Greer reported at the AAP’s annual meeting.

Full article

Immunizations and Alzheimers

The Immunization-Alzheimer´s Controversy

The adjuvants used in vaccines (putting the mercury issue aside) are intentionally highly inflammatory so as to provoke a more active immune response to the weakened pathogen. The fact that American children are the most vaccinated in the world at such an early age, when their brains are setting up shop, runs the high risk that vaccinations will “train” nerves to become more hyper-active to future inflammatory stress of any kind. Such issues would be magnified if a child had a history of stress in the womb, stress as an infant (unstable environment), poor nutrition in the womb or early life, other health problems as an infant, or has family-related gene weaknesses predisposing to Alzheimer´s (or any other nerve-related disease for that matter). These massive numbers of early vaccinations could easily set the stage for early onset Alzheimer´s. At this point there is absolutely no science that refutes this theory, and plenty of science to predict it.

More

Th1 and Th2 Response

Vaccines – The Great Debate

In addition to their toxic composition, the second problem with vaccinations is that they stimulate the wrong immune system. In my opinion, this is the greatest threat to our immune system that we have ever faced. You see, when a virus, parasites, or cancer cells threaten your body, they will activate an immune response called a Th1 (cell-mediated) response. This is your body’s first line of defense, which will then stimulate a Th2 response (humoral). The Th2 is an emergency response which produces antibodies that resolve inflammation so that healing can continue. The problem is that childhood vaccinations or flu shots stimulate the Th2 resonse, not the Th1, thus violating the natural sequence. This violation has serious consequences. First, when you stimulate a Th1 response, you produce a lifetime immunity; however, when you vaccinate, you need boosters every 3 to 5 years because the Th2 is stimulated first. In other words, you do not have a lifetime immunity.

Another danger in violating the Th2 response sequence is that it teaches your immune system to over-react with the wrong defenses, thus producing a high antibody count which then leads to temporary immunity. When the over reaction (the emergency responses) is repeated again and again, the immune system is now educated to respond in this way. This only confuses the body and drives the diseases internally deeper, thereby causing chronic diseases later in life. Top scientists have said that we are exchanging childhood diseases, which actually strengthen our immune system, for diseases like cancer and autoimmune problems.

Today, 206,000 Americans under the age of 20 have type 1 diabetes, a well-known autoimmune disorder. The CDC reports that 1 out of 400 children and adolescents are now diabetic. In 1945 and 1969, only 1 out of 7,100 faced this disease. J. Barthelow Classen, M.D., a former researcher at the National Institute of Health (NIH) and founder and CEO of Classen Immunotherapies, reported in the May 1996 New Zealand Medical Journal that juvenile diabetes increased 60% following a massive hepatitus B vaccination campaign (1988-1991) for New Zealand babies 6 weeks and older. Along with that, 1 out of 3 Americans has arthritis, and juvenile arthritis is likewise on the rise. Tragically, childhood cancer is also increasing, especially in highly vaccinated communities. We cannot even begin to follow the rise in asthma and allergies because of the great inconsistencies.

continued

Bias, Spin, and Misreporting: Time for Full Access to Trial Protocols and Results

Bias, Spin, and Misreporting: Time for Full Access to Trial Protocols and Results

An-Wen Chan

Although randomized trials provide key guidance for how we practice medicine, trust in their published results has been eroded in recent years due to several high-profile cases of alleged data suppression, misrepresentation, and manipulation [1–5, 39]. While most publicized cases have involved pharmaceutical industry trials, accumulating empiric evidence has shown that selective reporting of results is a systemic problem afflicting all types of trials, including those with no commercial input [6]. These examples highlight the harmful potential impact of biased reporting on patient care, and the violation of ethical responsibilities of researchers and sponsors to disseminate results accurately and comprehensively.

Biased reporting arises when two main decisions are made based on the direction and statistical significance of the data—whether to publish the trial at all, and if so, which analyses and results to report in the publication. Strong evidence for the selective publication of positive trials has been available for decades [7,8]. More recent cohort studies have focused on the misreporting of trials within publications by comparing journal articles either with documents from regulatory agencies [9–12] or with trial protocols from research ethics committees [13–16], funding agencies [17], research groups [18,19], and journals [20]. These cohort studies identified major discrepancies—favorable results were often highlighted while unfavorable data were suppressed; definitions of primary outcomes were changed; and methods of statistical analysis were modified without explanation in the journal article.

…Overall, a substantial amount of primary outcome data submitted to the FDA was found to be missing from the literature. One quarter of trials in their sample were unpublished—predominantly those with unfavorable results. Not only were data suppressed for the unpublished trials, but an additional quarter of primary outcomes were omitted from journal articles of published trials. These findings are consistent with two recent reviews of FDA documents and journal articles [10,21], one of which was published in PLoS Medicine in September 2008 [21].

Continued

Gulf War Syndrome

If You Let the Idiots Talk They’ll Tell You What You Want to Know

By Kent Heckenlively, Esq.

I’m still trying to get my mind around the 452 page government report recently released on Gulf War illness and its implications for the vaccine/autism controversy.

For those keeping score, two years ago the National Academy of Sciences released a report asserting there was no such thing as Gulf War illness.  (“VA-Funded Report Unable to Find Evidence of a Complex of Symptoms”, www.msnbc.com, September 13, 2006).

The congressionally mandated report entitled “Gulf War Illness and the Health of Gulf War Veterans” is devastating in its findings.  As reported in the November 17, 2008 of USA Today (“Gulf War Syndrome is a Real Illness, Study Finds”), “The illness resulted from exposure to chemicals and anti-nerve-gas vaccinations received, and no effective treatment has been found.  It affects 25% of the 695,000 U.S. Gulf War vets (author’s note – approximately 173,000 service members) and perhaps 55,000 British veterans.”

Continued

Research Advisory Committee on Gulf War Veterans’ Illnesses. Gulf War Illness and the Health of Gulf War Veterans: Scientific Findings and Recommendations (pdf)

Gulf War Illness and the Health of Gulf War Veterans

Georgia State Law (Daycare)

WHAT THE LAW SAYS

Local health officials often tell day care operators their centers are complying with the law as long as 90 percent of their children have proof of vaccinations, a temporary waiver or medical or religious exemption.

But the law says:

“No child shall be admitted to or attend any school or facility in this state unless the child shall first have submitted a certificate of immunization to the responsible official of the school or facility. …”

“Any responsible official permitting any child to remain in a school or facility in violation of this Code section, and any parent or guardian who intentionally does not comply with this Code section, shall be guilty of a misdemeanor and, upon conviction thereof, shall be punished by a fine of not more than $100.00 or by imprisonment for not more than 12 months.”

To read the full text of the law, O.C.G.A. 20-2-771, go here

To attend day care, depending on the child’s age, Georgia law may require vaccination against measles, mumps, rubella, polio, whooping cough, chickenpox, diphtheria, tetanus, hepatitis A and B, pneumococcal disease, and Haemophilus influenzae type B (Hib). Exemptions are allowed for medical and religious reasons.

Vaccine Information Sheet (VIS)

Vaccine Information Sheet (VIS)

 Vaccine information sheets are produced by the CDC.  In the US, it is a federal law that the VIS sheet be signed prior to any vaccine administration. It became a requirement with the passing of the National Childhood Vaccine Injury Act of 1986. The VIS sheets purpose is to describe a brief overview of the vaccine, the benefits, and the risks.

 

  It is NOT an informed consent sheet. A parent signs the sheet simply as an acknowledgment that they were informed of the benefits and risks.

 

There is no Federal requirement for informed consent. VISs are written to fulfill the information requirements of the NCVIA. But because they cover both benefits and risks associated with vaccinations, they provide enough information that anyone reading them should be adequately informed. Some states have informed consent laws, covering either procedural requirements (e.g., whether consent may be oral or must be written) or substantive requirements (e.g., types of information required). Check your state medical consent law to determine if there are any specific informed consent requirements relating to immunization. VISs can be used for informed consent as long as they conform to the appropriate state laws. (bolding mine)

 

According to an AAP survey regarding consent and immunizations: (bolding mine)

 

  • The majority of pediatricians distribute written information on these vaccines the first time they are administered: 73.0% always distribute written information on the DTP vaccine; 63.8% always do so for MMR; 60.6% always do so for HIB; and 65.4% always do so for OPV.
  • The majority of pediatricians also document provision of information in the patient’s record the first time a vaccine is administered. for the DTP vaccine, 61.3% of pediatricians said they always document provision of benefit/risk information, 56% reported always documenting information on the MMR, 53.8% always do so for the HIB vaccine, and for the OPV, 59.1% always do so.
  • Two-thirds of the pediatricians reported they never record a parent’s specific verbal consent in the patient’s record the first time a vaccine is administered. For the DTP vaccine, 19.1% of the pediatricians said they always record parent’s specific verbal consent and 15.6% said they sometimes do so. For MMR, 17.1% said they always do and 13.3%, sometimes. For the HIB vaccine, 16.4% said they always record the parent’s verbal consent in the record and 13.8% said they sometimes do so; for OPV, 18.9% always and 13.0% sometimes do so.

One-half of the pediatricians always obtain the parent’s signature as evidence of consent the first time a DTP, MMR, or OPV vaccine is administered; 47.5% do so for the HIB vaccine. Most of the balance of pediatricians said they never do so (39.8% DTP, 43.0% MMR, 46.3% HIB, and 42.9% OPV).

 

Another AAP survey:

 Vaccine administration practices vary as a function of practice setting, practice area and region of the country. For example, pediatricians in group practices (45%) are less likely than pediatricians in hospital/clinic practices (59%) or solo practices (51%) to say they discuss vaccine risks/benefits with every dose of at least six of the seven vaccines (p<.01). Pediatricians practicing in rural areas and those in the Midwest and South are more likely to distribute VIS at every dose than are pediatricians practicing in other areas (70% rural vs. 55% inner city vs. 64% other urban vs. 59% suburban, p<.05) or regions of the country (72% Midwest vs. 68% South vs. 54% West vs. 49% Northeast, p<.001). practitioners in rural areas (65%) also are more likely to document provision of VIS with every dose of each vaccine than are practitioners in urban inner cities (43%), other urban areas (58%) or suburban areas (54%) (p<.01).

vis

Doctors “firing’ Patients

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Refuse to get your child a vaccine and get ‘fired’ by your Pediatrician. Who would of thunk?

 Refuse Vaccine, Get ‘Fired’ by Pediatrician?

 Well over a third of pediatricians — 39% — say they would “dismiss” families that refuse all vaccinations, a new study suggests. That’s surprising, says study leader Erin A. Flanagan-Klygis, MD, assistant professor of pediatrics at Chicago’s Rush Medical College.

But another finding surprises Flanagan-Klygis even more. More than one in four pediatricians — 28% — say they would fire families that agreed to some vaccinations but refused one or more other vaccinations.

This study is based on questionnaires filled out by 302 randomly selected members of the American Academy of Pediatrics who give recommended childhood vaccinations. Ref: October issue of Archives of Pediatrics and Adolescent Medicine.

 

Dismissing the Family Who Refuses Vaccines

A Study of Pediatrician Attitudes

Results Fifty-four percent faced total vaccine refusal during a 12-month period. Pediatricians cited safety concerns as a top reason for parent refusal. Thirty-nine percent said they would dismiss a family for refusing all vaccinations. Twenty-eight percent said they would dismiss a family for refusing select vaccines. Pediatrician dismissers were not significantly different from nondismissers with respect to age, sex, and number of years in practice. Pediatrician dismissers were more likely than nondismissers to view traditional vaccines (diphtheria and tetanus toxoids and acellular pertussis; inactivated poliovirus; Haemophilus influenzae type b; measles, mumps, and rubella) as “extremely important,” but they were no more likely to view newer vaccines (7-valent pneumococcal conjugate, varicella-zoster virus, hepatitis B) as “extremely important.”

Conclusions Pediatricians commonly face vaccine refusal that they perceive to be due to parent safety concerns. In response, many pediatricians say they would discontinue care for families refusing some or all vaccines. This willingness to dismiss refusing families is inconsistent with an apparent ambivalence about newer, yet recommended, vaccines. The practice of family dismissal needs further study to examine its actual impact on vaccination rates, access to care, and doctor-patient relations.

 

Logically though, how can you as a parent or your child be ‘fired’?  They provide a service to YOU. You don’t work for THEM. Without YOU, who would THEY WORK FOR? Would you honestly want a physician that didn’t TRUST and RESPECT YOU to KNOW what is best for YOUR child?  Would you really want a physician that didn’t RESPECT your RIGHT to choose what you believe to be in the best interest of your child? Patients can fire their doctors. Doctors can only refuse to see you as a patient in the future. :)

 

 According to the American Medical Association, doctors have “an obligation to support continuity of care for their patients” and “should not neglect a patient.” But if a doctor must end the relationship, they have to provide enough notice so the patient can secure another health care provider.”

I’ve often found that doesn’t happen. Doctors simply tell patients to find a new doctor and in not so nice words. 

Take care when firing a patient

 A physician may legally and ethically decide not to continue treating a patient as long as the patient is not in need of immediate care and has been given a reasonable opportunity to find another doctor, which is consistent with the recommendations of the American Medical Association Council on Ethical and Judicial Affairs.

 

According to the AAP:

Responding to Parental Refusals of Immunization of Children

Douglas S. Diekema, MD, MPH and the Committee on Bioethics

 The American Academy of Pediatrics strongly endorses universal immunization. However, for childhood immunization programs to be successful, parents must comply with immunization recommendations. The problem of parental refusal of immunization for children is an important one for pediatricians. The goal of this report is to assist pediatricians in understanding the reasons parents may have for refusing to immunize their children, review the limited circumstances under which parental refusals should be referred to child protective services agencies or public health authorities, and provide practical guidance to assist the pediatrician faced with a parent who is reluctant to allow immunization of his or her child.

 

So much for the Hippocratic Oath. Or respecting a parents RIGHTS under the LAW. Perhaps they have even forgotten that vaccines are not mandatory. They are only mandated for school or daycare attendance, without an exemption.

 

Parents often feel they have to explain their reason for not vaccinating. Why? If a physician’s belief  is to vaccinate everyone under the sun, nothing you say will make a difference to them. If not vaccinating is your choice, own it. If you do not vaccinate for religious reasons, simply state it. You owe no further explanation and it is against the law for a physician to question your faith or religious beliefs further. If it is against your philosophical beliefs, much like religion, simply state it, and no further discussion needed. You don’t question their religious beliefs, so nothing gives them the right to question or discriminate against yours.

Bullying? Yes, I’ve heard this one too. Remember, only you allow a physician to bully you. If a physician is unethical and unprofessional enough to start it, calmly leave without comment. A physician has no right to bully, yell, discriminate, name call, harass or threaten you, ever. We would call those descriptions ‘abuse’ and that is exactly what they are doing, and they are not above the law.

 

Finding the Right Physician

1. Make a list of physician’s names and get references from friends or families who have similar views as yours.

2.  Call and ask the receptionist if non-vaccinating/selective/delay patients are accepted before making the first appointment.  If you are comfortable with the answers to your questions, book an appointment.

3. Direct any further questions directly to the physician at the appointment.

Omnibus Autism Proceeding

Omnibus Autism Proceeding

Latest news and court proceedings…

HepB vaccine injury case

JANE DOE/23, Petitioner, v. SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES, Respondent

 Office of Special Masters – U.S. Court of Federal Claims – “Each expert in the instant case agrees that optic neuritis is frequently a hallmark for MS. There is a logical sequence of cause and effect connecting petitioner’s exposure to hepatitis B vaccine and her onset of demyelinating disease. Petitioner has proved causation in fact.”

Invasive, paediatric, vaccine strains of Streptococcus pneumoniae: Are there differences in clinical characteristics?

Invasive, paediatric, vaccine strains of Streptococcus pneumoniae: Are there differences in clinical characteristics?

Abstract

Invasive pneumococcal infections in 777 adults caused by ‘invasive’ (1, 7; n=187), ‘paediatric’ (6, 9, 14, 19, 23; n=304) and other (n=286) serogroups were compared. Infections caused by ‘invasive’ strains caused pneumonia more often than other serogroups and were more often isolated from younger patients without concomitant conditions and had lower case-fatality rate than ‘paediatric’ and other strains. The 2 latter groups differed little from each other. Infections caused by strains in the 7-valent pneumococcal conjugate vaccine differed little from infections caused by non-vaccine types indicating that widespread use of this vaccine will not markedly change the clinical characteristics of invasive pneumococcal infections in adults.

Hepatitis B triple series vaccine and developmental disability in US children aged 1–9 years

Hepatitis B triple series vaccine and developmental disability in US children aged 1–9 years

 

Abstract

This study investigated the association between vaccination with the Hepatitis B triple series vaccine prior to 2000 and developmental disability in children aged 1-9 years (n = 1824), proxied by parental report that their child receives early intervention or special education services (EIS). National Health and Nutrition Examination Survey 1999-2000 data were analyzed and adjusted for survey design by Taylor Linearization using SAS version 9.1 software, with SAS callable SUDAAN version 9.0.1. The odds of receiving EIS were approximately nine times as great for vaccinated boys (n = 46) as for unvaccinated boys (n = 7), after adjustment for confounders. This study found statistically significant evidence to suggest that boys in United States who were vaccinated with the triple series Hepatitis B vaccine, during the time period in which vaccines were manufactured with thimerosal, were more susceptible to developmental disability than were unvaccinated boys.

Researchers Find Link Between Nicotine Addiction and Autism

Researchers Find Link Between Nicotine Addiction and Autism

November 17, 2008

Scientists have identified a relationship between two proteins in the brain that has links to both nicotine addiction and autism. The finding has led to speculation that existing drugs used to curb nicotine addiction might serve as the basis for potential therapies to alleviate the symptoms of autism.

The discovery identified a defining role for a protein made by the neurexin-1 gene, which is located in brain cells and assists in connecting neurons as part of the brain’s chemical communication system. The neurexin-1 beta protein’s job is to lure another protein, a specific type of nicotinic acetylcholine receptor, to the synapses, where the receptor then has a role in helping neurons communicate signals among themselves and to the rest of the body.

This function is important in autism because previous research has shown that people with autism have a shortage of these nicotinic receptors in their brains. Meanwhile, scientists also know that people who are addicted to nicotine have too many of these receptors in their brains.

If we were to use drugs that mimic the actions of nicotine at an early time in human brain development, would we begin to help those and other circuits develop properly and thus significantly mitigate the deficits in autism? This is a novel way of thinking about how we might be able to use drugs to approach autism treatment,” said Rene Anand, associate professor of pharmacology in Ohio State University’s College of Medicine and principal investigator of the research.

It would not be a complete cure, but right now we know very little and have no drugs that tackle the primary causes of autism.”

The drugs in question are known as cholinergic agents, which interact with the brain to counter nicotine addiction. Anand said the medications could be retailored for use in children in an effort to increase the level of neurexin-1 beta protein in the brains of people with autism.

More neurexin would in turn not only enhance the presence of nicotinic acetylcholine receptors, but also a host of other proteins that are important for the proper formation and maturation of synapses. Proper synapse function is critical to the nervous system’s ability to connect to and control other systems of the body.

Now that these associations have been made, we believe that nicotine in smokers’ brains possibly increases the level of neurexin-1 and, as a consequence, helps bring more receptors to the synapses and makes those circuits highly efficient, reinforcing the addiction. In autism, we have the opposite problem. We have a lack of these receptors, and we speculate that neurexin levels are lower,” he said.

Anand presented the research Monday (11/17) at the Society for Neuroscience meeting in Washington, D.C.

Autism symptoms include impaired social interaction, problems with verbal and nonverbal communication, and repetitive or severely limited activities and interests. An estimated three to six of every 1,000 children are diagnosed with autism, and boys are four times more likely than girls to have the disorder, according to the National Institute of Neurological Disorders and Stroke.

Anand and colleagues were studying drug abuse and addiction when they discovered the neurexin-1 beta protein’s relationship to a certain type of nicotinic receptor. The timing of the discovery was key, as it built upon two other research groups’ previous observations: The brains of people with autism and other neurological disorders that were examined after their death showed a 60-percent to 70-percent decrease in specific nicotinic receptors, and some patients with autism have mutations in the neurexin-1 gene that suggest the gene’s improper functions could play a role in the disorder.

These have all been ‘association studies.’ None has been able to prove what causes autism,” Anand said. “And then we accidentally discovered that neurexin-1 and nicotinic receptors tangle. So we knew that there was a genetic link to the process leading to synapse formation, and we had nicotinic receptors that had disappeared in the brains of autistic patients. Our finding filled a gap by saying there is a physical and functional association between these two things occurring in the brain.”

Neurexin has implications for tobacco addicts, as well, Anand said. Yet another group of researchers recently found that people with a mutation in the neurexin-1 gene were more likely to be smokers, meaning changes in the gene’s functions that lead to excess levels of the nicotinic receptors might make people more susceptible to nicotine addiction.

Our research reveals how changes in the functions of neurexin could affect the guidance of nicotinic acetylcholine receptors to their functional destinations in nerve cells, perhaps increasing receptors in tobacco addicts while decreasing them in autistic individuals, thus increasing susceptibility to these devastating neurological disorders,” Anand said.

The finding also has implications for nicotine addiction because drugs known to alter neurexin’s guidance of nicotinic receptors within nerve cells could be used to suppress tobacco addiction.

This work is partially funded by the National Institute on Drug Abuse, the National Alliance for Research on Schizophrenia and Depression, and by an OSU Medical Center Research Day Travel Award.

Coauthors of the study are Stephanie Amici and Susan McKay of Ohio State’s Department of Pharmacology; Shi-Bin Cheng, Xiao-Qin Ren, Magdalen Treuil and Jay Rao of the Louisiana State University Health Sciences Center in New Orleans; and Jon Lindstrom of the University of Pennsylvania.

Source: Ohio State University

FDA nixes state appeal to ban multi-dose vials

FDA nixes state appeal to ban multi-dose vials

The head of the U.S. Food and Drug Administration has rejected an appeal from New York State’s health commissioner to ban the manufacture of multi-dose vials, saying they are an important option for hospitals.

In January, state Health Commissioner Dr. Richard Daines and New York City’s health commissioner, Dr. Thomas Frieden, sent FDA Commissioner Dr. Andrew von Eschenbach a letter calling for the FDA to eliminate the manufacture and distribution of multi-dose vials.

Although there are federal and state guidelines against the practice, reusing syringes in multi-dose vials was the source of at least one hepatitis C transmission by Plainview pain management physician Dr. Harvey Finkelstein. The health department was criticized last November when it was revealed that because of legal delays and complicated lab tests, it had waited three years before telling the public of Finkelstein’s improper practice.

In a letter dated Jan. 18, both Daines and Frieden said that despite “numerous guidelines and recommendations,” some doctors continue to misuse needles and syringes, leading to contamination of multi-dose vials. Daines said he believed it was better to “engineer out” human error by getting rid of multi-dose vials.

Continued

Gulf War Research Panel Finds 1 In 4 Veterans Suffers From Illness Caused By Toxic Exposure

Gulf War Research Panel Finds 1 In 4 Veterans Suffers From Illness Caused By Toxic Exposure

At least one in four of the 697,000 U.S. veterans of the 1991 Gulf War suffer from Gulf War illness, a condition caused by exposure to toxic chemicals, including pesticides and a drug administered to protect troops against nerve gas, and no effective treatments have yet been found, a federal panel of scientific experts and veterans concludes in a landmark report released Monday.

Continued

Age of Autism View

Feckless IOM Does Agency’s Bidding: Sound Familiar?

National Vaccine Registry

National Vaccine Registry

 cover

Vaccines are now recorded and registered with your state’s vaccination registry.

 

According to the CDC:

 

Immunization Information Systems are confidential, population-based, computerized information systems that attempt to collect vaccination data about all children within a geographic area. IIS are an important tool to increase and sustain high vaccination coverage by consolidating vaccination records of children from multiple providers, generating reminder and recall vaccination notices for each child, and providing official vaccination forms and vaccination coverage assessments. One of the national health objectives for 2010 is to increase to 95% the proportion of children aged <6 years who participate in fully operational population-based IIS.

 

If you look further down the page you will find this statement:

 

State law requires that information in the IIS be kept confidential. Only you, your doctor, or healthcare workers who can assist you have access to the information. The information will not be shared with any other people or any other agency. If you are not interested in having your child in the IIS, all you would need to do is contact your state IIS and request to “opt-out” of the registry.

 

Healthcare workers would include Department of Health, CDC, and other government monitoring agencies. Is your child’s school a healthcare agency? Last I knew they were in the education field, yet they have access to it as well. Even the WIC program has linkages. See also: WIC Policy for Immunization Screening and Referral

 

Is this “opt-out” provision true? Not entirely. New York State no longer allows an ‘opt-out’ provision. That means, all children regardless of whether they are vaccinated or not, are in the system. If this vaccine registry was solely for its stated purpose above, why would nonvaccinated children need to be in it? They don’t need reminder notices or updated vaccination forms, etc.

 

Will children with medical or religious exemptions need to be included in NYSIIS?

  • These children will be entered in NYSIIS and their records noted with the appropriate exemption. NYSIIS is a valuable tool to identify and protect these children in the event of an outbreak of a vaccine preventable disease. (bolding mine)

 

Why not call it what it is: identify, track, control, and discriminate.

I have heard many stories over the last few years of parents who ‘opted out’ in other states, yet they have found their child in the vaccine registry. Wouldn’t that be a clear violation of the HIPPA law?  No, and here is why:

 

Shalala Will Decide Privacy Rights If Congress Does Not Meet Deadline

 HIPAA provided that, if Congress does not enact legislation to create standards to protect individually identifiable health information in medical records by August 21, 1999, then the Secretary of HHS is required to establish rules governing how much information the government and other third parties can get out of private medical records by February 21, 2000. Currently, there are four medical privacy bills in the House and Senate, including the Health Care Personal Information Nondisclosure Act of 1999 (S.578-Senators Jeffords/Dodd); the Medical Information Protection Act of 1999 (S.881-Senator Bob Bennett) and the Medical Information Privacy and Security Act (S.573/H.R. 1057-Leahy/Kennedy).

All of these medical “privacy” bills allow extensive exemptions for unrestricted access and use of personal medical information in an individual’s medical records by anyone who invokes a right to access and use this information in the name of the public health including government officials, researchers and law enforcement officers. Citizens can be enrolled without their informed consent as research subjects in medical experiments if researchers make the case that the study will contribute to the public health.

This means that, without the individual’s informed consent, researchers working with government, industry and private physicians will be allowed unrestricted access to personal medical records for the purpose of enrolling unsuspecting patients in medical research experiments. Scientific researchers of the future could experiment on citizens with new drugs and vaccines. The elderly will not know whether the nursing home doctor urging the use of a new antidepressant or the family pediatrician recommending to a mother that her infant get 15 vaccines in one day, is making that recommendation because it is in the best interest of the individual or because the doctor has enrolled his patients in a government-endorsed medical experiment.

 

 Often, when these parents have requested to opt-out, they have been given false information from the Department of Health or have had to jump through hoops to get their child’s name removed. I seriously question if their name is ever entirely removed.

 

 The AAP’s stance:

 
The American Academy of Pediatrics continues to support the development and implementation of immunization information systems, previously referred to as immunization registries, and other systems for the benefit of children, pediatricians, and their communities. Pediatricians and others must be aware of the value that immunization information systems have for society, the potential fiscal influences on their practice, the costs and benefits, and areas for future improvement.

 

Yes, the almighty dollar sign right in the first paragraph…cha-ching!

 

How did the National Vaccine registry come about? Who or where does it get its funding from?

 All Kids Count

 The All Kids Count II program, funded by The Robert Wood Johnson Foundation (RWJF) from 1998-2000, sought to make 16 immunization registry projects based in local, county, and state health departments fully operational by January 1, 2000. The program also sought to develop a long-term policy to ensure registries are implemented and sustained nationwide. The program built on progress made under All Kids Count Phase I, 1992-1997, an RWJF program to begin the development of registries.

The national program office was based at the Task Force for Child Survival and Development in Atlanta With guidance from the program’s National Advisory Committee, the national program office gave grants ranging from $300,000 to $700,000 to 16 projects.

RWJF’s Board of Trustees authorized up to $11.25 million for phase II beginning in 1997.

 

…In late 1997, public policy set the stage for All Kids Count projects and other state and community registries to take a giant step forward. President Bill Clinton issued a presidential directive to Secretary of Health and Human Services Secretary Donna Shalala “to start working with states on an integrated immunization registry system … we have to do it and do it right.”

 

As a result, an Initiative on Immunization Registries was undertaken by the National Vaccine Advisory Committee (NVAC), with support from the National Vaccine Program Office (NVPO) and the National Immunization Program of the CDC.

At the same time, more communities and states were developing or implementing registries. In 1998, when All Kids Count II began:

 

All 50 states had begun developing immunization registries.

Some 18 states had a law or rule authorizing immunization registries.

Ten states and several cities had mandated private provider reporting of immunizations to registries.

In 2001, 25 states had a law or rule authorizing immunization registries, and several states planned to introduce legislation or rules authorizing registries.

 …Educational Effort
All Kids Count began an intensive effort with immunization partners, especially the National Immunization Program, American Academy of Pediatrics and Every Child by Two (a non-profit organization that raises awareness of the importance of getting children fully immunized by the time they are two years old) to inform policymakers about the benefits, costs, and savings of registries, and the need to find a sustained source of funding if the promise of registries were to be realized.

 …The education effort culminated in a legislative briefing held May 1, 2000, in Washington, D.C. Hosted by former First Lady Rosalynn Carter and Mrs. Betty Bumpers, co-founders of Every Child by Two, the briefing had bi-partisan sponsorship from members of the Senate and House. Leading health organizations, health care professional organizations, and education organizations co-sponsored the briefing.

Carter and Bumpers urged legislators to find the political will and financial backing for development of immunization registries.

 New Federal Attention and Funding

…The education effort paid off. At the July 2000 National Immunization Conference, Secretary of Health and Human Services Donna Shalala promised support through the Medicaid program.

In Fall 2000, Medicaid announced its commitment to fund development and implementation of immunization registries at an enhanced rate of up to 90 percent matching funds for registry costs associated with Medicaid-eligible children (approximately 26 percent of children under age 7).

 

In June 2000, the Institute of Medicine issued Calling the Shots: Immunization Finance Police and Practices, a report on the future of the nation’s immunization system. It noted that community immunization information systems are an important tool to help keep children from but that a commitment must be made to ensure their success.

 

The report, approved by NVAC in January 2001, recommended:

 Continued and increased support for registries through the federal immunization grant program.

Wide promotion of use of Medicaid funds for registries.

Seeking approval to use the CDC’s Vaccines for Children operational funds for registries.

Discussions with insurers/health plans urging them to provide support for registries.

Development of a five-year, $60-million a year grant program to support further development and initial operation of registries.

 

…As All Kids Count II closed in 2001, The Robert Wood Johnson Foundation funded All Kids Count for three years to develop a vision for information systems that will integrate data about multiple health services.

 

 Immunization Registry Strategic Plan 2002-2007

Medicare and Medicaid funding

Federal Direct Assistance Grant Funds

Research Grants

Tween 80 ( Polysorbate 80)

Vaccines containing Tween 80 (Polysorbate 80):

 

DTaP-all brands

DTaP/HepB/IPV (Pediarix)

HPV-Gardasil

Influenza-Fluarix

Japanese Encephalitis-JE-Vax

 

 

 

 

A study published in December, 2005 discovered that Tween80 can cause anaphylaxis, a sometimes fatal reaction characterized by a sharp drop in blood pressure, hives, and breathing difficulties. Researchers concluded that the severe reaction was not a typical allergic response characterized by the combination of IgE antibodies and the release of histamines; it was caused by a serious disruption that had occurred within the immune system.

(Coors, Esther A., Seybold, Heidi, Merk, Hans, Mahler, Vera. “Polysorbate 80 in medical products and nonimmunologic anaphylactoid reactions,” Annals of Allergy, Asthma and Immunology 95 (2005): 593–599.)

 

The study also included a pregnant woman who suffered anaphylactic shock after being given an IV drip of multi-vitamins containing polysorbate 80. There have been numerous studies which show that the stabilizer causes infertility. Source:

(Gajdova M, Jakubovsky J, Valky J.Delayed effects of neonatal exposure to Tween 80 on female reproductive organs in rats. Food Chem Toxicol. 1993 Mar;31(3):183-90. PMID: 8473002.)

Infant female rats were injected with polysorbate 80 at days 4-7 after birth. It accelerated the maturing of the rats and caused changes to the vagina and womb lining, hormonal changes, ovary deformities and degenerative follicles.

 

According to the World Intellectual Property Organization, which is part of the United Nations, scientists from the organization are developing vaccines specifically to damage fertility as a method of contraception. A suggested ingredient for the vaccine is tween 80 (polysorbate 80):

“In a preferred embodiment the vaccine comprises oil, preferably a biodegradable oil such as squalene oil. Typically, the vaccine is prepared using an adjuvant concentrate which contains lecithin in squalene oil. The aqueous solution glycoprotein is typically a phosphate-buffered saline (PBS) solution, and additionally preferably contains Tween 80.”

(Fertility Impairing Vaccine And Methods of Use’ This application claims the benefit of U. S. Provisional Application No. 60/070,375, filed January 2,1998, U. S. Provisional Application No. 60/071,406, filed January 15,1998.)

 

Gardasil contains Polysorbate 80, which is linked to infertility in mice,” noted Dee Nicholson, National Communications Director for Freedom in Canadian Health Care. It is stated clearly in the manufacturer’s information sheet that comes with the vaccine.

Vaccine adjuvants: The dream becomes real

 

After about 70 years two new adjuvants have been approved for human vaccines. The first is MF59 developed by the ex-Chiron now Novartis Vaccines and it consists in an oil-in-water emulsion, comprising a low content of biodegradable squalene oil (4.3%) as the dispersed phase, which is stabilized by two non-ionic surfactants (Tween 80 and Span 85), and a low ionic strength citrate buffer as the continuous phase. The second defined as AS04 it has been developed by GSK Biologics it consists in 3-0-descyl-4’-monophosporyl lipid A (MPL) that comes from the cell wall LPS of Gram-negative Salmonella minnesota R595 and is detoxified by mild hydrolytic treatment and purification. It is absorbed on aluminum hydroxide or aluminum phosphate. Thus, new molecules are available to improve the immune response to vaccine also in humans: this is the beginning of a new era in vaccinology.

The current research on the stabilizer Tween 80 reveals the following:

“Neonatal female rats were injected ip (0.1 ml/rat) with Tween 80 in 1, 5 or 10 percent aqueous solution on days 4-7 after birth. Treatment with Tween 80 accelerated maturation, prolonged the oestrus cycle, and induced persistent vaginal oestrus. The relative weight of the uterus and ovaries was decreased relative to the untreated controls. Squamous cell metaplasia of the epithelial lining of the uterus and cytological changes in the uterus were indicative of chronic oestrogenic stimulation. Ovaries were without corpora lutea, and had degenerative follicles.” ~ PMID: 8473002

 

 

Female lab rats injected with Tween 80 developed impaired sexual organs as well as premature development of their sexual organs.

 

 

Adjuvants–a classification and review of their modes of action

 

Water-in-oil emulsions

These are microdroplets of water, stabilized by surfactant (typically mannide monooleate) in a continuous oil phase (typically mineral oil, squalene or squalane). Freund’s incomplete adjuvant (FIA) has been used for human and veterinary vaccines, but is now largely discredited (perhaps unjustly) due to a low incidence of site reactivity. Emulsions based on metabolizable oils have a superior safety profile.

They are poorly immunomodulatory (in absence of local irritant effect), provide good short term depots, are inexpensive, relatively simple to formulate and induce good antibody responses especially for hydrophilic immunogens. W/o emulsions provide an excellent formulation into which soluble immunomodulators can be incorporated. Emulsions can be unstable.

 

Oil-in-water (o/w) emulsions

These are microdroplets of oil (typically squalene or squalane, size about 290 nm), stabilized by surfactants (typically Tween 80 and/or Span 85) in a continuous water phase and are under development as human vaccine adjuvants, frequently in association with soluble immunomodulators [e.g., muramyl dipeptide (MDP) derivatives or block copolymers]. O/w emulsions result in excellent antigen presentation and moderate targeting.

They are inexpensive, safe and excellent basic formulations into which lipophilic immunomodulators can be incorporated: in addition they are highly suited for amphipathic molecules where presentation is important. It is important to incorporate immunogen into the oil phase.

 

Gardasil Mandated For New U.S. Citizens

Gardasil Mandated For New U.S. Citizens

If at first you don’t succeed, try, try, again. That’s exactly what the giant drug company Merck has done; it changed its lobbying target and now has the federal government mandating injections of its vaccine for legal immigrants, ensuring a continuous return on its product development investment.

Continued

Autism, Vaccines and Human Nature

Autism, Vaccines and Human Nature  By Lisa Jo Rudy

For decades, the magical team of Penn and Teller have been traveling the world, making TV programs, and entertaining Vegas audiences with a show that specifically and effectively debunks the idea that “seeing is believing.” The Amazing Randi has offered $1000000 to anyone that can demonstrate paranormal abilities under laboratory conditions – a prize which is still outstanding.

Despite these high-profile efforts to convince the public that seeing is not believing, many, many people believe wholeheartedly in scientifically unproven phenomena ranging from UFO’s to ESP to communication with the dead. Many of those people will tell you flat out that scientific studies can’t possibly trump the fact that they experienced those phenomena themselves. Some will even say “seeing is believing,” and they will mean it.

Despite a basic understanding of probability, untold millions believe, wholeheartedly, that they will beat the odds in the lottery or at the casino. Millions are presented with convincing studies and public education campaigns that make it crystal clear that smoking, poor diets and lack of exercise lead to life-threatening illness – yet they believe that they will beat the odds.

Knowing all this, I can’t help but feel that doctors and researchers have a strenuous uphill battle on their hands as they strive to explain the science behind vaccines, and the math behind risk analysis.

I just received a book called Do Vaccines Cause That?! by Drs. Martin Myers and Diego Pineda. The purpose of the book, as I understand it, is to demystify vaccines – and thus to make it clear to parents that the risks inherent in avoiding vaccines are far, far greater than the risks inherent in having their children vaccinated. To make the book friendlier, the authors include cartoons – and the publisher created a fun, engaging cover and selected a relatively large font. This really does make the book easier to read, and friendlier to approach.

Flipping through the table of contents, I was impressed by the chapter titles. “Vaccine Side Effects and Risk Perception: What if My Child Is the One in a Million?” and “Cause or Coincidence: How Do I Tell Whether or Not a Vaccine Caused That?!” While the use of exclamation points and question marks may be a little overwhelming, the topics, I thought, were right on.

But when I actually read the chapters, I found that the book was going in a direction quite different from what I expected. The question “What if My Child Is the One in a Million” is unlikely to be resolved, for example, by the authors’ discussion of relative risk. Of course it’s true that we’re taking a greater risk by driving our child to the doctor for a vaccination than we are by allowing the doctor to inject our child. But if our knowledge of relative risk really influenced our behavior, casinos, cigarettes and Keno games would have long since perished from the Earth.

If we live in the world, we can’t avoid cars. We CAN avoid vaccines. So… the real question here is not “what’s riskier than vaccines?” but rather “is there any reliable way to know whether my child is likely to have an adverse reaction to vaccines, and if so – will you, my pediatrician, use that technique to ensure the safety of this shot?”

It’s one thing to involve your child in the daily risks of modern life. It’s another to knowingly and deliberately subject your child to a medical procedure that (at least according to some) could lead to serious consequences. I know, I know – risk analysis tells me there’s virtually nothing to worry about. But were I, today, faced with the question of vaccinations for a newborn infant, would I be comfortable in “just saying yes?” Being a human mother living in today’s world, I’m not sure the choice, even for me, would be simple.

 

698-01-1

Paul Offit’s Lies: What Would You Do?

…My message is still up there on the EOH message board, it’s message #17717 and you can read it for yourself. Now, you may disagree with the message I wrote, you may disagree with its tone, and you may disagree with my reaction to the situation at hand. But, at least you know the circumstances that surrounded the decision I made, and that’s what I really want you to know.

I really want you to know and understand what happened and why I wrote the note I wrote because once you do, you can see what a profoundly dishonest and manipulative liar Paul Offit really is.

You see, this post from EOH, or at least an excerpt from it, actually made it in to Paul Offit’s book, that book that will remain nameless, but the one we all know the name of. Yup, a piece of my post from EOH, the one where I was trying to tell the person hassling one of our Rescue Angels at work to back the hell off, made Offit’s book.

But, you wouldn’t know that from what Offit wrote.

You see, Paul Offit has a passage using a portion of this post, but it’s used for an entirely different reason. Rather than try to explain, I’m just going to share the passage from the book that will remain nameless, on page 145:

Read Entire Article

MF59 and Squalene

MF59 is an adjuvant which is a chemical used to increase the immune system’s response to an antigen.

 

 

MF59:

 

MF59TM is a sub-micron oil-in-water emulsion of a squalene, polyoxyethylene sorbitan monooleate (TweenTM 80) and sorbitan trioleate.  Squalene is a natural organic compound originally obtained from shark liver oil and a biochemical precursor to steroids. The MF59 adjuvant was developed by Chiron Corp., a company acquired by Novartis.  MF59 is approved in Europe and is found in several vaccines, such as an influenza vaccine manufactured by Novartis.  It has also been licensed to other companies and is being actively tested in vaccine trials.

 

 Chiron Announces Promising Data from Clinical Study of Adjuvanted Avian Influenza Vaccine; Results Confirm Previous Clinical Studies: Chiron’s MF59 Adjuvant Significantly Enhances Immune Response

 

 

Safety of MF59™ adjuvant

 

 

Researchers Try to Boost Supply of Flu Vaccine

 

…We are in possession of one of the key ingredients of a potential solution to the pandemic threat,” said Howard Pien, president of Chiron Corp. The California biotech firm has an adjuvant, an emulsion called MF59 whose main constituent is shark-liver oil. It is already in use in a flu vaccine in Europe.

“We believe that the adjuvant may become the holy grail of vaccines,” Chrystyna Bedrij, an analyst with Griffin Securities, wrote in November in a review of avian flu-related business.

 

Vaccines with the MF59 adjuvant do not stimulate antibody responses against squalene. (Research Center, Novartis Vaccines, Via Fiorentina 1, 53100 Siena, Italy.)


Squalene is a naturally occurring oil which has been used in the development of vaccine adjuvants, such as the oil-in-water emulsion MF59. In past years, by use of noncontrolled and nonvalidated assays, a claim was made that antisqualene antibodies were detectable in the sera of individuals with the so-called Gulf War syndrome. Using a validated enzyme-linked immunosorbent assay for the quantitation of immunoglobulin G (IgG) and IgM antibodies against squalene, we demonstrated that antisqualene antibodies are frequently detectable at very low titers in the sera of subjects who were never immunized with vaccines containing squalene. More importantly, vaccination with a subunit influenza vaccine with the MF59 adjuvant neither induced antisqualene antibodies nor enhanced preexisting antisqualene antibody titers. In conclusion, antisqualene antibodies are not increased by immunization with vaccines with the MF59 adjuvant. These data extend the safety profile of the MF59 emulsion adjuvant.

 

 FLU SHOTS AND THE NEW ADJUVANTS: BEWARE! By Dr. Sherri Tenpenny

…When molecules of squalene enter the body through an injection, even at concentrations as small as 10 to 20 parts per billion, it can lead to self-destructive immune responses, such as autoimmune arthritis and lupus.[9]

Several mechanisms have been proposed to explain this reaction. Metabolically, squalene stimulates an immune response excessively and nonspecifically. More than two dozen peer-reviewed scientific papers from ten different laboratories throughout the U.S., Europe, Asia, and Australia have been published documenting the development of autoimmune disease in animals subjected to squalene-based adjuvants.[10] A convincing proposal for why this occurs includes the concept of “molecular mimicry” in which an antibody created against the squalene in MF59 can cross react with the body’s squalene on the surface of human cells. The destruction of the body’s own squalene can lead to debilitating autoimmune and central nervous system diseases.

The squalene in MF59 is not the only cause for concern. One of its components, Tween80 (polysorbate 80) is considered to be “inert” but is far from it. A recent study (December 2005) discovered that Tween80 can cause anaphylaxis, a sometimes fatal reaction characterized by a sharp drop in blood pressure, hives, and breathing difficulties. Researchers concluded that the severe reaction was not a typical allergic response characterized by the combination of IgE antibodies and the release of histamines; it was caused by a serious disruption that had occurred within the immune system.[11]

Vaccine manufacturer, Chiron, is already using MF59 in its European influenza vaccine for seniors called Fluad™. It remains to be seen if Chiron will gain approval for using this adjuvant-containing vaccine in the U.S…

 

Vaccine A:  THE COVERT GOVERNMENT EXPERIMENT  THAT’S KILLING OUR SOLDIERS and Why GIs Are Only the First Victims

 

1.   Many new vaccines feature recombinant DNA. One piece of a deadly germ is inserted or spliced into other organisms, creating bio-engineered microbial molecules. To prompt the body to create antibodies to these recombinants, scientists have created deadly oil-based vaccine additives called adjuvants. Oil-based adjuvants cause extreme inflammation and animals injected with them always develop painful, incurable auto-immune diseases like multiple sclerosis, rheumatoid arthritis or systemic lupus.

 

2.   Since Gulf War I, the military has been secretly putting an oil-based adjuvant called SQUALENE into certain experimental lots of military vaccines. Just like lab animals, thousands of soldiers given SQUALENE- laced vaccines have developed disabling auto-immune diseases. Independent researchers have found SQUALENE antibodies in these sick soldiers. In 2005, the military admitted that 1,200 military personnel who received anthrax vaccine before going to Iraq recently developed serious illnesses, including memory loss and chronic fatigue.

 

3.  The military and federal health agencies have long kept their SQUALENE experiments on U.S. military troops secret because they know that oil-based adjuvants wreak havoc with immune function, causing the body to attack itself. Matsumoto documents how federal and military officials have often been caught lying about the SQUALENE in military vaccines.

 

4.  Matsumoto warns that the National Institutes of Health has funded production of new vaccines for flu, human papilloma virus, malaria, HIV and herpes that also contain SQUALENE. The federal government has been running human clinical tests on these new commercial vaccines and test subjects have not been properly informed of the grave health dangers. Researchers have even found SQUALENE in some of the older vaccines containing tetanus and diphtheria toxoids. Should we wonder why auto-immune diseases like fibromyalgia and chronic fatigue are now rampant?

 

5.    The Bush administration is funding development of new bio-warfare vaccines that will also contain oil- based SQUALENE adjuvants like MF59 or MPL. Because federal officials know that these vaccines may cause disability or death, legislation to protect vaccine makers from lawsuits is expected to be passed by Congress before the end of 2005.* If you become chronically ill from these vaccines, tough luck!

 

 

Antibodies to Squalene in Recipients of Anthrax Vaccine

 

We previously reported that antibodies to squalene, an experimental vaccine adjuvant, are present in persons with symptoms consistent with Gulf War Syndrome (GWS) (P. B. Asa et al., Exp. Mol. Pathol 68, 196–197, 2000). The United States Department of Defense initiated the Anthrax Vaccine Immunization Program (AVIP) in 1997 to immunize 2.4 million military personnel. Because adverse reactions in vaccinated personnel were similar to symptoms of GWS, we tested AVIP participants for anti-squalene antibodies (ASA). In a pilot study, 6 of 6 vaccine recipients with GWS-like symptoms were positive for ASA. In a larger blinded study, only 32% (8/25) of AVIP personnel compared to 15.7% (3/19) of controls were positive (P _ 0.05). Further analysis revealed that ASA were associated with specific lots of vaccine. The incidence of ASA in personnel in the blinded study receiving these lots was 47% (8/17) compared to an incidence of 0% (0/8; P _ 0.025) of the AVIP participants receiving other lots of vaccine. Analysis of additional personnel revealed that in all but one case (19/20; 95%), ASA were restricted to personnel immunized with lots of vaccine known to contain squalene. Except for one symptomatic individual, positive clinical findings in 17 ASA-negative personnel were restricted to 4 individuals receiving vaccine from lots containing squalene. ASA were not present prior to vaccination in preimmunization sera available from 4 AVIP personnel. Three of these individuals became ASA positive after vaccination. These results suggest that the production of ASA in GWS patients is linked to the presence of squalene in certain lots of anthrax vaccine. © 2002 Elsevier Science (USA).

  

The Endogenous Adjuvant Squalene Can Induce a Chronic T-Cell-Mediated Arthritis in Rats

 

…Our demonstration that an autoadjuvant can trigger chronic, immune-mediated joint-specific inflammation may give clues to the pathogenesis of rheumatoid arthritis, and it raises new questions concerning the role of endogenous molecules with adjuvant properties in chronic inflammatory diseases.

 

 

A Spoonful of Honey is Good Medicine

A spoonful of honey can do more than just satisfy your sweet tooth — it might improve your health.

For centuries, the natural sweetener has served as a versatile healing agent. Folk remedies featuring honey have long been used to treat ailments ranging from the common cold to constipation.

After the development of antibiotics and other modern drugs, honey fell from favor as a medicinal agent in the 1940s, but lately, it’s making a comeback. A growing body of scientific evidence proving the health benefits of honey is putting this ancient remedy back into modern day medicine chests.

In a recent issue of the International Journal of Clinical Practice, researchers reviewed 18 studies on honey performed over the past 60 years. They concluded that the natural sweetener appears to be a viable treatment for surgical wounds, especially those that become infected or fail to heal properly.

Hydrogen peroxide and other ingredients in honey make it useful for sterilizing infected wounds and preventing infection. When used as a topical dressing, it reduced amputation rates among diabetic patients.

Honey has been shown to have potent antibiotic properties. Scientists have discovered that it naturally produces hydrogen peroxide, a substance capable of killing disease-causing bacteria.

Its high concentration of sugar, low moisture content and acidic pH create an inhospitable environment for invading organisms. Because it fights bacteria in numerous ways, it’s ideal for combating superbugs that have developed resistance to standard antibiotics.

Additional natural ingredients appear to reduce inflammation and speed the repair of damaged tissue. Honey covers injured tissue with a thick, protective barrier, preventing contamination with dirt and germs. Each of these healing properties makes honey an excellent wound dressing. As an added bonus, it’s far less expensive than comparable medicinal products.

Researchers in India found that when burn victims’ wounds were treated with honey, they experienced less pain and scarring than those treated with more conventional medications. Superficial burns covered with honey-laden skin dressings healed far faster than those treated with silver sulfadiazine, an ointment commonly prescribed for mild to moderate burns.

While honey’s antibiotic properties help promote faster wound healing, its antifungal properties can provide relief for many common skin conditions, including ringworm, athlete’s foot and yeast infections.

 

 

As a fungus-fighter, honey appears to be comparable to many over-the-counter antifungal preparations.

Scientists recently found that psoriasis sufferers may benefit from applications of a mixture of honey, beeswax and olive oil. In a study of people suffering from psoriasis and other inflammatory skin disorders, 60 percent showed significant improvement when treated with the honey-based mixture.

Honey’s healing powers may also work from the inside out, boosting the body’s natural disease-fighting ability when taken by mouth. To test this theory, researchers at the University of California, Davis, asked volunteers to consume about four tablespoons of honey daily for one month.

Blood samples taken at the beginning and end of the 30-day period showed a direct link between honey consumption and levels of disease-fighting antioxidants in the bloodstream.

The results of the study led researchers to conclude that consuming honey on a daily basis can help protect individuals from oxidative stress caused by free radicals. Oxidative stress is known to contribute to a number of chronic conditions, including Alzheimer’s, cancer and cardiovascular disease.

The antioxidants in honey, called polyphenols, are similar to those found in fruits, vegetables and olive oil. Polyphenols are thought to reduce the risk of many diseases by disarming disease-causing free radicals in the body.

If you like the flavor of honey, you might want to use it as a marinade for meat. Not only does it promote browning and glaze formation, it reduces the production of cancer-causing compounds during grilling and frying.

One type of carcinogen, called heterocyclic aromatic amine, is formed when high cooking temperatures cause meats to char or blacken. Researchers at Michigan State University demonstrated that when meats are covered in marinades consisting of 30 percent honey for four hours, formation of HAA during cooking is significantly reduced.

Honey shouldn’t be given to children younger than one year of age. Occasionally, it can contain spores of the bacteria known to cause botulism, a rare but potentially fatal condition, especially in infants.

For healthy adults, small amounts are not only safe, they might even be beneficial. Whether you spread it on your bread or slather it on your skin, a spoonful of honey is good medicine.

Rallie McAllister is a board-certified family physician, speaker and the author of several books, including “Healthy Lunchbox: The Working Mom’s Guide to Keeping You and Your Kids Trim.” Her website is http://www.rallieonhealth.com. To find out more about Rallie McAllister, M.D., and read features by other Creators Syndicate writers and cartoonists, visit the Creators Syndicate Web page at http://www.creators.com.

COPYRIGHT 2008 CREATORS SYNDICATE, INC.

 

 

 

 

 

 

 

Medicine Cabinet Basics

Medicine Cabinet Basics

 

Aloe Vera gel for stomach/digestion problems. 

Acidophilus to help treat yeast problems, digestive issues, and when using antibiotics.

Vitamin C -an immune booster.

Echinacea – an immune booster. 

Garlic- an immune booster and natural antibiotic.

Valerian Root – for stress, sleeplessness, relaxer.

Hylands Homeopathic colic tabs. 

Hylands Homeopathic teething gel. 

Ginger root can be steeped in hot water to settle an upset stomach.

Neosporin for wounds.

 Hydrogen peroxide for wounds. 

Cranberry capsules for urinary tract problems. 

Benadryl cream/stick pen for insect bites. Also works well on bee stings. 

Benadryl-liquid for allergic reactions.

Grapefruit Seed extract for fungal problems.

Flaxseed or Fish oil capsules for EFA’s.

Cod-Liver Oil for EFA support and Vitamin A.

Raw Honey can be used for coughs and other uses.

Apple Cider Vinegar for digestive issues, chicken pox and Shingles treatment.

Licorice Root helps with coughs. 

Epsom salts for muscle aches.

Baking Soda. 

Rubbing Alcohol. 
Vicks Vapor Rub can be applied to the feet, cover with socks, and quiets a cough at night.

Lavender oil is an antiseptic, pimple reducer, burn/ pain relief and healing relaxation.

Tea tree oil is an antiseptic. 

 Ear infection

 Olive oil & garlic Remedy –

1 pint of olive oil and 1 clove of garlic, finely chopped. Simmer on the stove for 30 minutes. Strain it into a clean mason jar and let it cool. Put 3-7 drops to the ear as needed until the infection clears. It  can be stored in the refrigerator for up to 2 years. Drops should be room temperature or slightly warm before administering to the ear.

Is yeast your problem?

A wider perspective, common among complementary practitioners was popularised in the book, The Yeast Connection. The author, a Dr Crook, described a condition in which the main features are fatigue, intestinal disturbance, chronic infections, allergies, skin problems, poor concentration, depression, irritability and cravings for sweets or other carbohydrates. This is called the yeast syndrome.

This yeast syndome is thought to be due to an overgrowth of yeast multiplying in the intestines and producing toxins. Because this has not been intensively researched and subjected to peer review, conventional doctors remain skeptical of the existence of this syndrome. On the other hand, there is substantial clinical and anecdotal evidence that it exists and that it appears to be connected to the rampant overuse and abuse of antibiotics.

Many patients who have been diagnosed with the condition get better when they follow the kind of programme outlined below.

More

Present and Past U.S. Vaccine Schedules

 1980:

1980

1983-2007:

1983-to-2007

 1990:

HepB- Birth, 2 months, 6 months

DTP- 2mon, 4 mon, 6 mon, 15-18mon, 4-6 years

HIb- all doses between 2-18months

Polio- 4mon, 6mon, 15-18mon, 4-6years

MMR-15 mon, 4years

Td- 14-16 years

 

 

1996:

1996

 1997:

1997

1998:

1998

 

1999:

 

2000:

2000

 

2002:

2002

2004:

 

2004

 

2005:

2005

2007:

2007

 

2008:

2008

1960’s and 1970’s:

DPT

Individual doses of Measles, Mumps, Rubella OR MMR

OPV

Smallpox (before 1972)

 

Belief

What is a belief? It is basically a mental conviction of what one believes to be true. It essentially makes up who you are as it affects your whole life and the decisions you make. This thus forms your belief system. Your belief system is what you live by and tends to be habitual and unwavering. You weren’t born with beliefs. Your beliefs were shaped by you from inputs throughout your life through teachings of others, society, and personal experiences.

 

The vaccine issue is often centered on a belief system.  For instance, an individual who chooses to vaccinate may believe they are safe, believe they are important to health, believe that vaccines are responsible for the decline or elimination of disease, or believe anything their doctors tell them in relation to vaccines. Another example is an individual that believes vaccines aren’t safe, harms health, or do not believe doctors know best. In both examples, their belief systems can outweigh science regardless of what science shows. A belief system becomes more important than facts. An individual or the science itself can provide all the facts, but an individual’s belief system will triumph over facts.

 

 

We all have a need for certainty. Certainty keeps us comfortable. It makes us feel in control and safe, able to understand things, and make our predictions about the world. The need for certainty and a belief system go hand in hand. If a belief system is serving you well, you won’t abandon it on facts. When individuals discuss the vaccine issue, to vaccinate or not to vaccinate, for example; no matter what medical literature is cited, it may allow an acknowledgement, but their choice and decision to vaccinate or to not vaccinate, will generally remain the same because it won’t allow their need for certainty, or their belief system, to be tainted.

 

There are individuals whose beliefs concerning vaccines have changed, or those who look into the vaccine issue for the first time who may not have developed a strong belief system on the issue yet. Generally, individuals that change their beliefs do so because their original belief system tumbled and it no longer served them. This is often seen with parents of vaccine damaged children, or with new parents who are not willing to take the risk of vaccine damage. For them, the risks of vaccines outweigh the risk of illness. When new parents look at the issue with no preconceived belief system, they generally investigate both sides of the issue. Based on what they investigate, they will make their decision and thus form their belief system and their need for certainty.

 

 

 beleif

Aluminum and Vaccines (part 2)

IgE and Allergy

 
IgE is according to Wikipedia:

 is a class of antibody (or immunoglobulinisotype“) that has only been found in mammals. It plays an important role in allergy, and is especially associated with type 1 hypersensitivity

Although IgE is typically the least abundant isotype – blood serum IgE levels in a normal (“non-atopic“) individual are… it is capable of triggering the most powerful immune reactions.

It’s Role in Disease:

Atopic individuals can have up to 10 times the normal level of IgE in their blood (as do sufferers of hyper-IgE syndrome). However, this may not be a requirement for symptoms to occur as has been seen in asthmatics with normal IgE levels in their blood – recent research has shown that IgE production can occur locally in the nasal mucosa, without the involvement of lymphoid tissue[9].

IgE that can specifically recognise an “allergen” (typically this is a protein, such as dust mite DerP1, cat FelD1, grass or ragweed pollen, etc.) has a unique long-lived interaction with its high affinity receptor, FcεRI, so that basophils and mast cells, capable of mediating inflammatory reactions, become “primed”, ready to release chemicals like histamine, leukotrienes and certain interleukins, which cause many of the symptoms we associate with allergy, such as airway constriction in asthma, local inflammation in eczema, increased mucus secretion in allergic rhinitis and increased vascular permeability, ostensibly to allow other immune cells to gain access to tissues, but which can lead to a potentially fatal drop in blood pressure as in anaphylaxis. Although the mechanisms of each response are fairly well understood, why some allergics develop such drastic sensitivities when others merely get a runny nose is still one of science’s hot topics. Regulation of IgE levels through control of B cell differentiation to antibody-secreting plasma cells is thought to involve the “low affinity” receptor, FcεRII or CD23[citation needed]. CD23 may also allow facilitated antigen presentation, an IgE-dependent mechanism whereby B cells expressing CD23 are able to present allergen to (and stimulate) specific T helper cells, causing the perpetuation of a Th2 response, one of the hallmarks of which is the production of more antibodies.

 

Adjuvant Activity of Alum in Inducing Antigen Specific IgE Antibodies in BALB/c Mice: a reevaluation

 

New-Age Vaccine Adjuvants: Friend or Foe?  A major unsolved challenge in adjuvant development is how to achieve a potent adjuvant effect while avoiding reactogenicity or toxicity

adjuvantsgraph

A major unsolved challenge in adjuvant development is how to achieve a potent adjuvant effect while avoiding reactogenicity or toxicity.3 Most newer human adjuvants including MF59,4 ISCOMS,5 QS21,6 AS02,7 and AS048 have substantially higher local reactogenicity and systemic toxicity than alum. Even alum, despite being FDA-approved, has significant adverse effects including injection site pain, inflammation, and lymphadenopathy, and less commonly injection-site necrosis, granulomas, or sterile abscess.9 Although many adjuvant-caused vaccine reactions are not life-threatening and do resolve over time, they remain one of the most important barriers to better community acceptance of routine prophylactic vaccination. This particularly applies to pediatric vaccination where prolonged distress in the child due to increased reactogenicity may lead directly to parental and community resistance to vaccination.10 Hence, particularly in the context of childhood prophylactic vaccines, it is critical that suitable adjuvants be developed with lower reactogenicity and greater safety. Ideally, in addition to being safe and well tolerated, adjuvants should promote an appropriate (humoral and/or cellular) immune response, have a long shelf-life, and should be stable, biodegradable, cheap to produce, and not induce immune responses against themselves…”

 

Aluminum Salts (Alum) Aluminum, once ingested, is toxic to cells13 and by the time they reach the draining lymph node most of the macrophages that have ingested aluminum particles will be dead or dying. Once necrotic, the macrophages release their cytoplasmic contents, including alum-absorbed antigen and inflammatory mediators such as IL-1 and TNF, into the lymph. This provides a source of macrophage cell debris, antigen, and co-stimulatory cytokines flowing into the draining lymph node, a potent mix to stimulate antigen-specific plasma cells and antibody production. Interestingly, a similar mechanism was proposed many years ago to explain the adjuvant action of beryllium, a compound which is even more toxic to macrophages than aluminum, and has potent adjuvant activity.

 

 

Limitations of alum. Although aluminum salts remain the most commonly used adjuvants and the only ones currently approved for use in humans by the FDA, they suffer from a number of downsides, including inability to induce cytotoxic T-lymphocyte (CTL) responses critical in many cases for viral protection and clearance.15 Well-recognized problems of aluminum adjuvants include local injection site reactions, stimulation of eosinophilia, augmentation of IgE antibody responses, ineffectiveness for some antigens, and failure to enhance CTL responses. Alum is reasonably well tolerated when injected intramuscularly, with only mild to moderate injection pain and occasional granulomas. Risk of granulomas becomes particularly high when alum-based vaccines are injected subcutaneously or intradermally. Consequently, alum-containing vaccines are generally given by intramuscular injection.

 

 

 The mechanism for alum’s tendency to stimulate eosinophilia and enhance IgE production is unknown, but its consequence is an increased risk of vaccine allergy and anaphylaxis.9,16,18,19 This potential has been demonstrated in animal models of ovalbumin-induced asthma or anaphlylaxis, which are dependent on alum in the initial priming. In humans, there have been reports of a chronic inflammation syndrome called macrophagic myofascitis (MMF) being induced by alum-based vaccines.

 

To continue reading: here

 

Scientists discover how common vaccine booster works

 

 

In an online paper in the journal Nature, Yale University researchers funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, explain how a common ingredient in many vaccines stimulates and interacts with the immune system to help provide protection against infectious diseases.

 

Vaccines must possess not only the bacterial or viral components that serve as targets of protective immune responses, but also ingredients to kick start those immune responses. In many vaccines, the bacterial or viral components themselves have this capability. For other vaccines, the immune system requires an added boost. Adjuvants are those substances added to a vaccine to help stimulate the immune system and make the vaccine more effective.

 

Currently the only vaccine adjuvants licensed for general use in the United States are aluminum hydroxide/phosphate formulations, known as alum. Although alum has been used to boost the immune responses to vaccines for decades, no one has known how it worked.

 

 

In this paper, the Yale team, led by Richard Flavell, M.D., Ph.D., and Stephanie Eisenbarth, M.D., Ph.D., examined the immune system pathway and cell receptors used by alum. Many microbial compounds function as adjuvants by stimulating Toll-like receptors. These receptors identify microbial invaders and alert the body to the presence of a disease-causing agent, or pathogen. Alum, however, does not stimulate Toll-like receptors. The Yale team found that alum stimulates clusters of proteins called inflammasomes, found inside certain cells. Inflammasomes respond to stresses such as infection or injury by releasing immune cell signaling proteins called cytokines. Inflammasomes are a component of the innate immune system that operates in parallel with, but separate from, Toll-like receptors, also part of the innate immune system.

 

To make this determination, Dr. Eisenbarth and her coworkers used mice that had been genetically engineered to be deficient in various components of a specific type of inflammasome, characterized by the presence of the protein termed Nalp3. The team demonstrated that an immune response did not occur in those animals with the deficient Nalp3 inflammasomes, despite the inclusion of alum, while it did occur in normal mice. The team’s findings provide the first convincing evidence that the Nalp3 inflammasome forms the basis for alum’s adjuvant action.

 

According to the study authors, several unanswered questions remain regarding how activation of this pathway controls a highly specific and long-lasting immune response generated by a vaccine. But this new information on the molecules that alum uses to activate the innate immune system should provide the keys to better understanding adjuvant function and should facilitate the design of new vaccine adjuvants.

 

 

 Aluminum and Vaccine Ingredients:  What Do We Know? What Don’t We Know?

 

 

…In 1996, the American Academy of Pediatrics issued a position paper on Aluminum Toxicity in Infants and Children which stated in the first paragraph, “Aluminum is now being implicated as interfering with a variety of cellular and metabolic processes in the nervous system and in other tissues.

 

A review of the medical literature on aluminum reveals a surprising lack of scientific evidence that injected aluminum is safe. There is limited understanding of what happens to children when aluminum is injected into their bodies, including whether or not it accumulates in tissues and organs or is properly eliminated from the body. It is also unknown if genetic factors affect long term adverse health outcomes for those injected with aluminum containing vaccines.

 

…Ten percent of all children have asthma.[5] Growing numbers of children are living with different types of allergies. That means they have impairment, or even irreversible damage to their nervous and immune systems. Isn’t it possible that injected aluminum plays a role in affecting the health of our children’s nervous and immune systems, as the science we do have seems to suggest?

 

What is even more concerning is the lack of accepted scientific data explaining whether injected aluminum interacts with other vaccine ingredients to cause harm to our children. Boyd Haley, PhD, Professor Emeritus of Chemistry at the University of Kentucky completed lab experiments showing the damaging effects on nerve cells when he exposed them to aluminum, especially in the presence of other vaccine ingredients like mercury, formaldehyde, and the antibiotic neomycin.[6] [7] His data, however, have been ignored by the scientific, medical and governmental institutions making vaccine policies.[8] The scientific community needs to be doing these experiments in the lab before shooting kids with these ingredients and declaring unequivocal vaccine safety for all children.

 

 
Aluminum is placed in the vaccines to selectively target the up-regulation of the humoral arm (TH2 cells) of children’s immune systems, to drive the production of antibodies. The medical community leads us to believe that this production of antibodies is what imparts for children a protective nature against vaccine-preventable illnesses. Yet, this outcome may come at a cost.

There are multiple articles in the medical literature demonstrating how chronic illnesses like allergies,[11] [12] asthma, [13] [14] [15] eczema,[16] lupus, [17] inflammatory bowel disease, [18] ADD/ADHD[19] and autism[20] all exhibit a skewed production and over-activity of the TH2 arm of the immune system.

Similarly, chronic illnesses like juvenile diabetes mellitus[21] [22] and rheumatoid arthritis,[23] multiple sclerosis,[24] uveits,[25] inflammatory bowel disease,[26] and autism[27] [28] all exhibit skewed production and over-activity of the TH1 arm of the immune system.

 

…What is clear is aluminum pushes the TH2 immune system to over perform, and multiple chronic illnesses in children show immune systems where the TH2 immune response over performs, while TH1 and TH3 responses are also impaired. Is there a connection? By having this type of effect on the TH2 system, is aluminum in any way contributing to the development of these chronic illnesses in children; especially in those children from families with a genetic history of the above mentioned chronic illnesses?

 

…Under these circumstances, the activity of aluminum appears to play a vital role in disrupting the maturation of the immune system in infants and children through its effects on TH2 and therefore, on TH1 and TH3.

 

…We have no scientific studies in infants, children or adults to help us understand the nature of the progression of TH1, TH2 and TH3 immune responses to any of the injected materials in vaccines.

 

 

Vaccine adjuvants: the dream becomes real.

 

After about 70 years two new adjuvants have been approved for human vaccines. The first is MF59 developed by the ex-Chiron now Novartis Vaccines and it consists in an oil-in-water emulsion, comprising a low content of biodegradable squalene oil (4.3%) as the dispersed phase, which is stabilized by two non-ionic surfactants (Tween 80 and Span 85), and a low ionic strength citrate buffer as the continuous phase. The second one, defined as AS04, has been developed by GSK Biologics and consists in 3-0-desacyl- 4′-monophosphoryl lipid A (MPL) that comes from the cell wall LPS of Gram-negative Salmonella minnesota R595 and is detoxified by mild hydrolytic treatment and purification. It is absorbed on aluminum hydroxide or aluminum phosphate. Thus, new molecules are available to improve the immune response to vaccines also in humans: this is the beginning of a new era in vaccinology.

 

alumbodyburden

 

MRL means “minimum risk level”. At that point you might start seeing toxic effects such as psychosis. At the two, four, and 6 month shots, it’s clearly exceeded.  Only the aluminum amounts from DTaP and HepB were used. However, babies often get in addition to that, HIB and Prevnar.

 

Workshop on Aluminum in Vaccines, San Juan , Puerto  Rico. May 11, 2000. Pg. 170+

alumpuertorico2000

Puerto Rico Meeting/Transcript On Aluminum In Vaccines – part 1 of 2

Puerto Rico Meeting/Transcript On Aluminum In Vaccines – part 2 of 2

 

Edited to add:

 

Vaccine-Related Chronic Fatigue Syndrome In An Individual Demonstrating Aluminium Overload

A team of scientists have investigated a case of vaccine-associated chronic fatigue syndrome (CFS) and macrophagic myofasciitis in an individual demonstrating aluminium overload.

This is the first report linking aluminium overload with either of the two conditions and the possibility is considered that the coincident aluminium overload contributed significantly to the severity of these conditions in a patient.

The team, led by Dr Chris Exley, of the Birchall Centre at Keele University in Staffordshire, UK, has found a possible mechanism whereby vaccination involving aluminium-containing adjuvants could trigger the cascade of immunological events that are associated with autoimmune conditions, including chronic fatigue syndrome and macrophagic myofasciitis.

The CFS in a 43-year-old man, with no history of previous illness, followed a course of five vaccinations, each of which included an aluminium-based adjuvant. The latter are extremely effective immunogens in their own right and so improve the immune response to whichever antigen is administered in their presence. While the course of vaccinations was cited by an industrial injuries tribunal as the cause of the CFS in the individual, it was not likely to be a cause of the elevated body burden of aluminium. The latter was probably ongoing at the time when the vaccinations were administered and it is proposed that the cause of the CFS in this individual was a heightened immune response, initially to the aluminium in each of the adjuvants and thereafter spreading to other significant body stores of aluminium.

The result was a severe and ongoing immune response to elevated body stores of aluminium, which was initiated by a course of five aluminium adjuvant-based vaccinations within a short period of time. There are strong precedents for delayed hypersensitivity to aluminium in children receiving vaccinations which include aluminium-based adjuvants, with as many as 1% of recipients showing such a response.

While the use of aluminium-based adjuvants may be safe, it is also possible that for a significant number of individuals they may represent a significant health risk, such as was found in this case. With this in mind the ongoing programme of mass vaccination of young women in the UK against the human papilloma virus (HPV) with a vaccine which uses an aluminium based adjuvant may not be without similar risks.

Recent press coverage of myalgic encephalomyelitis (ME) or chronic fatigue syndrome has highlighted the potentially debilitating nature of this disease and related conditions. The cause of CFS is unknown.

 

PDF: Vaccine-related chronic fatigue syndrome in an individual demonstrating aluminium overload

 

 

 

 

 

Emergence of Streptococcus pneumoniae Serotypes

Emergence of Streptococcus pneumoniae Serotypes 19A, 6C, and 22F and Serogroup 15 in Cleveland, Ohio, in Relation to Introduction of the Protein-Conjugated Pneumococcal Vaccine

Clinical Infectious Diseases 2008;47:1388–1395    2008

Background.  A 7-valent conjugate pneumococcal vaccine (PCV7) was introduced in 2000.

Methods.  We determined serotypes and assessed antimicrobial susceptibility of 1235 invasive and noninvasive isolates of Streptococcus pneumoniae recovered from children and adults at University Hospitals Case Medical Center (Cleveland, OH) during the period 1999–2007.

Results.  The annual number of cases of S. pneumoniae infection decreased from 218 in 2000 to 86–130 during the period 2002–2007, with the number of cases involving invasive strains decreasing from 96 to 18–35. For 1999 versus 2005–2007, the annual incidence of vaccine serotypes decreased by 92% (95% confidence interval [CI], −96.3% to −87.0%), whereas that of vaccine-related and nonvaccine serotypes increased 207.4% (95% CI, 135.0%–297.7%) and 18.4% (95% CI, −10.0% to 52.3%), respectively. Serotypes 19A, 6C, and 22F and serogroup 15 accounted for most of these increases. For the period 2005–2007, antimicrobial susceptibility testing revealed that ceftriaxone was the most active parenteral β-lactam for both meningeal and nonmeningeal infections (72% and 88% of isolates, respectively, were susceptible to this agent); only 52% were susceptible to penicillin G at the meningeal breakpoint, whereas 77% were susceptible at the new nonmeningeal breakpoint of 2 μg/mL. Amoxicillin was the most active oral β-lactam (72% of isolates were susceptible), whereas 53% of isolates were susceptible to azithromycin, 69% to clindamycin, 63% to trimethoprim-sulfamethoxazole, and 100% to levofloxacin.

Conclusions.  This study documents decreases in the incidence of infections involving vaccine serotypes, increases in infections involving other serotypes, and decreases in the activity of macrolides and clindamycin after conjugate vaccine introduction.

Mumps Outbreaks in Vaccinated Populations

Mumps Outbreaks in Vaccinated Populations: Are Available Mumps Vaccines Effective Enough to Prevent Outbreaks?

Clinical Infectious Diseases 2008;47:1458–1467  2008

Increased reports of mumps in vaccinated populations prompted a review of the performance of mumps vaccines. The effectiveness of prior vaccination with 1 dose of vaccine ranged from 72.8% to 91% for the Jeryl Lynn strain, from 54.4% to 93% for the Urabe strain, and from 0% to 33% for the Rubini strain. Vaccine effectiveness after 2 doses of mumps vaccine was reported in 3 outbreaks and ranged from 91% to 94.6%. There was evidence of waning immunity, which is a likely factor in mumps outbreaks, aggravated by possible antigenic differences between the vaccine strain and outbreak strains. Inadequate vaccine coverage or use of the Rubini vaccine strain accounted for the majority of outbreaks reviewed; however, some outbreaks could not be prevented, despite high vaccination coverage with 2 doses of the Jeryl Lynn vaccine strain. Our findings indicate the need for more-effective mumps vaccines and/or for review of current vaccination policies to prevent future outbreaks.

*In the US-the Mumps strain we use is the Jeryl Lynn** (B level) strain.  

Aluminum in Vaccines (part 1)

The US licensed vaccines for children that contain aluminum adjuvants are:

  DTaP

 Brands:

 Daptacel-330micrograms as aluminum potassium sulfate

Tripedia-170micrograms

Infanrix-625micrograms as aluminum hydroxide

 

DTaP/Hib

 Brand:

 TriHIBit- 0.170 mg of aluminum

 

DTaP/HepB/IPV

 Brand:

 Pediarix-850 mcg as aluminum phosphate

 

 DtaP/Hib/IPV

 Brand:

 Pentacel-1500micrograms

 

 DT (sanofi)

DT (Massachusetts)

 Tdap

 Brands:

Adacel– identical to DTaP but with less formaldehyde and 1.5 mg aluminum phosphate

Boostrix-390micrograms as aluminum hydroxide

 

Td (Decavac)

Td (Massachusetts)

 

Pneumococcal

 Brand:

  Prevnar-125 mcg as aluminum phosphate 

 

 Human Papillomavirus (HPV)

 Brand:

 Gardasil- 225mcg as amorphous aluminum hydroxyphosphate

 

Hepatitis A

Brands:

Vaqta– 250 micrograms amorphous aluminum hydroxyphosphate sulfate

Havrix– 250 micrograms as aluminum hydroxide

Hepatitis A/Hepatitis B

 Brand:

 Twinrix- 0.45 mg of aluminum in the form of aluminum hydroxide and aluminum phosphate as adjuvants

 

Hepatitis B

 Brands:

 Recombivax- 250micrograms as amorphous aluminum hydroxyphosphate sulfate

EngerixB– 250 micrograms as aluminum hydroxide

 

HIB/HepB

 Brand:

Comvax– 225 micrograms as amorphous aluminum hydroxyphosphate Sulfate

 

HIB

 Brands:

 PedvaxHib– 225micrograms as aluminum hydroxyphosphate sulfate 

 

Anthrax

Brand:

 BioThrax- 1.2 mg/ml aluminum, added as aluminum hydroxide in 0.85% sodium   chloride

 

  
The amount of aluminum in the recommended individual dose of a biological product shall not exceed 1.250mg.  However, infants are exceeding the maximum recommended dose depending on which vaccine is given, and how many vaccines are being given in one day. This far exceeds the FDA’s safety limit on aluminum.

“The FDA determined that babies should not get more than about 25 to 50 micrograms of aluminum in any one day,” Dr. Sears says. “If too much aluminum is injected all at once, it can find its way into the brain, bones and body organs and cause damage. This was discovered many years ago in hospitalized patients who were receiving IV solutions containing too much aluminum.”

 

 Aluminum neurotoxicity has been recognized in experimental animals, in individuals with renal failure, and links to neurodegenerative disorders to aluminum exposure. Also, aluminum content in infant formulas, and in intravenous solutions for home parenteral nutrition, has been associated with neurological consequences and metabolic bone disease, characterized by low-bone formation rate. 
 
Symptoms of mild to moderate acute aluminum phosphide toxicity may include nausea, agitation and chills, restlessness, abdominal pain, tightness in chest, and excitement. Symptoms of aluminum toxicity may include disorientation, colic, memory loss, headaches, learning difficulty, mental confusion, heartburn, loss of coordination, and flatulence. More severe symptoms of toxicity may include tachycardia (rapid pulse), diarrhea, respiratory failure, cyanosis, dizziness and/or death, difficulty breathing, pulmonary edema, and hypotension (low blood pressure). Convulsions have been to occur in lab animals exposed to high concentrations of phosphine. Severe exposure may indicate kidney damage. Pathological examination of exposed laboratory animal tissue and results of post-mortem examinations of phosphine poisoning in people generally indicate hypoxia, along with evidence of local trauma in the gastrointestinal tract or lungs, liver, kidneys and central nervous system.  
 

 Aluminum is highly reactive and a T2 skewer. It is used in vaccines because without it the body won’t react to weak strains of antigens. Aluminum ‘wakes up’ and keeps the antigen presenting cells to the ‘on’ position. It creates more antigen presenting cells because without it, the vaccine won’t provoke antibodies. Why? Because the bacteria did not get there by normal portals of entry.

 

The antigen presenting cells can cause problems. Dendritic cells that present antigen for too long will allow abnormal antibodies to be produced; also known as autoantibodies. Antigen presenting cells from vaccines promote a better immune response and aluminum ensures this abnormal response.

 

When macrophages cross the blood brain barrier they take aluminum with them and are thus affected by aluminum as well. They can become loaded with aluminum particles and disrupt their function. Aluminum can integrate into molecular functions but it is also a neurotoxin. It alters permeability of the blood-brain barrier making the brain more accessible to other toxins in the body, just as Thimerosal can.  

 

Aluminum hydroxide when used in vaccines is injected through the skin right to the tissue where it is absorbed and enters the brain.

 

The only known cause of Macrophagic myofasciitis has an association with aluminum adjuvant vaccines.

 

Macrophagic myofasciitis leasions assess long-term persistence of vaccine-derived aluminum hydroxide in muscle.

 

“Macrophagic myofasciitis (MMF) is an emerging condition of unknown cause, detected in patients with diffuse arthromyalgias and fatigue, and characterized by muscle infiltration by granular periodic acid-Schiff’s reagent-positive macrophages and lymphocytes. Intracytoplasmic inclusions have been observed in macrophages of some patients. To assess their significance, electron microscopy was performed in 40 consecutive cases and chemical analysis was done by microanalysis and atomic absorption spectrometry. Inclusions were constantly detected and corresponded to aluminium hydroxide, an immunostimulatory compound frequently used as a vaccine adjuvant. A lymphocytic component was constantly observed in MMF lesions. Serological tests were compatible with exposure to aluminium hydroxide-containing vaccines. History analysis revealed that 50 out of 50 patients had received vaccines against hepatitis B virus (86%), hepatitis A virus (19%) or tetanus toxoid (58%), 3-96 months (median 36 months) before biopsy. Diffuse myalgias were more frequent in patients with than without an MMF lesion at deltoid muscle biopsy (P < 0.0001). Myalgia onset was subsequent to the vaccination (median 11 months) in 94% of patients. MMF lesion was experimentally reproduced in rats. We conclude that the MMF lesion is secondary to intramuscular injection of aluminium hydroxide-containing vaccines, shows both long-term persistence of aluminium hydroxide and an ongoing local immune reaction, and is detected in patients with systemic symptoms which appeared subsequently to vaccination.”

 

  Aluminum-Adjuvanted Vaccines Transiently Increase Aluminum Levels in Murine Brain Tissue

 

Summary: This British group injected aluminum-containing vaccines into mice and found that levels of the metal rose in the brain and peaked around the third day after injection. Aluminum from vaccines enters the brain almost immediately after it is injected and measurable amounts of aluminum are present at the injection site for up to 8 years after vaccination.

 

Abstract: “Aluminium is widely used as an adjuvant in human vaccines, and children can often receive up to 3.75 mg of parenteral aluminium during the first six months of life. We show that intraperitoneal injection of aluminium adsorbed vaccines into mice causes a transient rise in brain tissue aluminium levels peaking around the second and third day after injection. This rise is not seen in the saline control group of animals or with vaccine not containing aluminium. It is likely that aluminium is transported to the brain by the iron-binding protein transferrin and enters the brain via specific transferrin receptors.”

 

 Myelin is a preferential target of aluminum-mediated oxidative damage.

 

Myelin is the protective protein which coats neurons and covers the spinal cord. Damage to this protein is referred to as demyelination.  Multiple Sclerosis, Acute Disseminated Encephalomyelitis, Autism, Transverse Myelitis, and Optic Neuritis  are examples of demyelinating diseases when damage to myelin causes neurological dysfunction.

 

Aluminum-induced oxidative events and its relation to inflammation: a role for the metal in Alzheimer’s disease.

  

Abstract : Aluminum (Al) is a simple trivalent cation incapable of redox changes. The toxicity of the metal has been the subject of much controversy in the past few decades. Although it has been generally believed that the metal is innocuous to human health, a causal role for Al has been established in dialysis dementia (Alfrey et al., 1976), osteomalacia (Bushinsky et al., 1995) and microcytic anemia without iron deficiency (Touam et al., 1983). Aluminum has also been implicated in Alzheimer’s disease (AD) although a direct causal role has not been determined. The exact mechanism of Al toxicity is not known. However, there are several lines of evidence that show the metal’s capacity to exacerbate oxidative events. The present review is intended to propose a coherent pathway linking Al-induced oxidative events to Alzheimer’s disease. The preliminary segment is an introduction to reactive oxygen species and their potential involvement in the pathogenesis of AD and the generation of an inflammatory response. Evidence on the relation between AD and inflammatory processes is also presented. The epidemiological and clinical evidence of Al neurotoxicity is summarized in the second section of the review. Finally, a hypothesis indicating that aluminum can exacerbate AD by activating ROS generation and initiation of an inflammatory cascade is presented.

 

Alum adjuvanticity: unraveling a century old mystery.

 

“The development of vaccine adjuvants for human use has been one of the slowest processes in the history of medicine. For almost one century, aluminium hydroxide (alum) has been the only vaccine adjuvant approved worldwide. Only in the past decade have two oil-in-water emulsions and one TLR agonist been approved by the European authorities as new vaccine adjuvants. Despite the fact that alum has been injected into billions of people, its mechanism of action is not fully understood. Recently, several reports have greatly increased our knowledge of the molecular and cellular events triggered by alum; however, the contribution of each of these processes to alum adjuvanticity is still unclear. A study published in this issue of the European Journal of Immunology, together with two recent publications, have demonstrated that the NOD-like receptor, pyrin domain containing 3 (Nlrp3)-inflammasome is the molecular target of alum immunostimulatory activity in vitro. Surprisingly, these three studies reported conflicting results on the requirement of the Nlrp3 inflammasome complex for alum adjuvant effects in vivo. This commentary attempts to resolve some of these discrepancies.”

 

 Aluminum adjuvant linked to gulf war illness induces motor neuron death in mice.  

 

Abstract: “Gulf War illness (GWI) affects a significant percentage of veterans of the 1991 conflict, but its origin remains unknown. Associated with some cases of GWI are increased incidences of amyotrophic lateral sclerosis and other neurological disorders. Whereas many environmental factors have been linked to GWI, the role of the anthrax vaccine has come under increasing scrutiny. Among the vaccine’s potentially toxic components are the adjuvants aluminum hydroxide and squalene. To examine whether these compounds might contribute to neuronal deficits associated with GWI, an animal model for examining the potential neurological impact of aluminum hydroxide, squalene, or aluminum hydroxide combined with squalene was developed. Young, male colony CD-1 mice were injected with the adjuvants at doses equivalent to those given to US military service personnel. All mice were subjected to a battery of motor and cognitive-behavioral tests over a 6-mo period postinjections. Following sacrifice, central nervous system tissues were examined using immunohistochemistry for evidence of inflammation and cell death. Behavioral testing showed motor deficits in the aluminum treatment group that expressed as a progressive decrease in strength measured by the wire-mesh hang test (final deficit at 24 wk; about 50%). Significant cognitive deficits in water-maze learning were observed in the combined aluminum and squalene group (4.3 errors per trial) compared with the controls (0.2 errors per trial) after 20 wk. Apoptotic neurons were identified in aluminum-injected animals that showed significantly increased activated caspase-3 labeling in lumbar spinal cord (255%) and primary motor cortex (192%) compared with the controls. Aluminum-treated groups also showed significant motor neuron loss (35%) and increased numbers of astrocytes (350%) in the lumbar spinal cord. The findings suggest a possible role for the aluminum adjuvant in some neurological features associated with GWI and possibly an additional role for the combination of adjuvants.”

Quote:

“Similar adjuvants are used in the following vaccines, according to Shaw’s paper: hepatitis A and B, and the Pentacel cocktail, which vaccinates against diphtheria, pertussis, tetanus, polio, and a type of meningitis.”

 

“… After 20 weeks studying the mice, the team found statistically significant increases in anxiety (38 percent); memory deficits (41 times the errors as in the sample group); and an allergic skin reaction (20 percent). Tissue samples after the mice were “sacrificed” showed neurological cells were dying. Inside the mice’s brains, in a part that controls movement, 35 percent of the cells were destroying themselves.”

 

  Nanomolar aluminum induces pro-inflammatory and pro-apoptotic gene expression in human brain cells in primary culture.

 Abstract: “Aluminum, the most abundant neurotoxic metal in our biosphere, has been implicated in the etiology of several neurodegenerative disorders including Alzheimer’s disease (AD). To further understand aluminum’s influence on gene expression, we examined total messenger RNA levels in untransformed human neural cells exposed to 100 nanomolar aluminum sulfate using high density DNA microarrays that interrogate the expression of every human gene. Preliminary data indicate that of the most altered gene expression levels, 17/24 (70.8%) of aluminum-affected genes, and 7/8 (87.5%) of aluminum-induced genes exhibit expression patterns similar to those observed in AD. The seven genes found to be significantly up-regulated by aluminum encode pro-inflammatory or pro-apoptotic signaling elements, including NF-kappaB subunits, interleukin-1beta precursor, cytosolic phospholipase A2, cyclooxygenase-2, beta-amyloid precursor protein and DAXX, a regulatory protein known to induce apoptosis and repress transcription. The promoters of genes up-regulated by aluminum are enriched in binding sites for the stress-inducible transcription factors HIF-1 and NF-kappaB, suggesting a role for aluminum, HIF-1 and NF-kappaB in driving atypical, pro-inflammatory and pro-apoptotic gene expression. The effect of aluminum on specific stress-related gene expression patterns in human brain cells clearly warrant further investigation.”

 

 So, Aluminum interacts directly with DNA. Exogenous aluminum interacts via membrane contact and with cell signaling events. Both mechanisms take place and around 30 genes can be affected. Seven of which are significantly up-regulated or in other words, genes that are primarily pro-inflammatory or pro-apoptotic: apoptosis means cell suicide. The consequences for brain development are still unknown since there has not been enough research done to date. However, it is known that aluminum in vaccines is sufficient to induce abnormal gene expression in the brain.

 

Aluminum salts in vaccines-US perspective

 

Abstract: Aluminum in the form of aluminum hydroxide, aluminum phosphate or alum has been commonly used as an adjuvant in many vaccines licensed by the US Food and Drug Administration. Chapter 21 of the US Code of Federal Regulations [610.15(a)] limits the amount of aluminum in biological products, including vaccines, to 0.85 mg/dose. The amount of aluminum in vaccines currently licensed in the US ranges from 0.85-0.125 mg/dose. Clinical studies have demonstrated that aluminum enhances the antigenicity of some vaccines such as diphtheria and tetanus toxoids. Moreover, aluminum-adsorbed diphtheria and tetanus toxoids are distinctly more effective than plain fluid toxoids for primary immunization of children. There is little difference between plain and adsorbed toxoids for booster immunization. Aluminum adjuvants have a demonstrated safety profile of over six decades; however, these adjuvants have been associated with severe local reactions such as erythema, subcutaneous nodules and contact hypersensitivity.

 

*The views in this article are those of the authors and are not intended to represent those of the Food and Drug Administration or the Public Health Service.

 

Vaccines containing Aluminum are not the only source of aluminum exposure for infants. Aluminum is present in air, food and water so infants are exposed to aluminum in the environment. Breast milk alone can contain approximately 40 µg of aluminum per liter, and infant formulas can contain an average of approximately 225 µg of aluminum per liter. Since large quantities of aluminum can cause serious neurologic effects in humans, guidelines were established by the Agency for Toxic Substances and Disease Registry(ATSDR).

 

 ATSDR-Potential for Human Exposure:

 

Since aluminum is ubiquitous in the environment, the general population will be exposed to aluminum by the inhalation of ambient air and the ingestion of food and water. The consumption of foods containing aluminum-containing food additives are a major sources of aluminum in the diet (Saiyed and Yokel 2005; Soni et al. 2001). The use of other consumer items such as antiperspirants, cosmetics, internal analgesics (buffered aspirins), anti-ulcerative medications, antidiarrheals, and antacids that also contain aluminum compounds will result in exposure to aluminum. The intake of aluminum from food and drinking water is low, especially compared with that consumed by people taking aluminum-containing medicinal preparations. Daily intakes of aluminum from food range from 3.4 to 9 mg/day (Biego et al. 1998; MAFF 1999; Pennington and Schoen 1995), whereas aluminum-containing medications contain much higher levels of aluminum, for example 104-208 mg of aluminum per tablet/capsule/5 mL dose for many antacids (Zhou and Yokel 2005). While aluminum is naturally present in food and water, the greatest contribution to aluminum in food and water by far is the aluminum-containing additives used in water treatment and processing certain types of food such as grain-based products and processed cheese. Aluminum has no known physiological role in the human body (Nayak 2002).

 

The aluminum content of human breast milk generally ranged from 9.2 to 49 μg/L (Fernandez-Lorenzo et al. 1999; Hawkins et al. 1994; Koo et al. 1988; Simmer et al. 1990; Weintraub et al. 1986). Soy-based infant formulas contain higher concentrations of aluminum, as compared to milk-based infant formulas or breast milk. Recent reports provide average aluminum concentrations of 460-930 μg/L for soy-based infant formulas and 58-150 μg/L for milk-based formulas (Fernandez-Lorenzo et al. 1999; Ikem et al. 2002; Navarro-Blasco and Alvarez-Galindo 2003).

 

 Occupational exposures to aluminum occur during the mining and processing of aluminum ore into metal, recovery of scrap metal, production and use of aluminum compounds and products containing these compounds, and in aluminum welding. Individuals living in the vicinity of industrial emission sources and hazardous waste sites; individuals with chronic kidney failure requiring long-term dialysis or treatment with phosphate binders; patients requiring intravenous fluids; infants, especially premature infants fed soy-based formula containing high levels of aluminum; and individuals consuming large quantities of antacids, anti-ulcerative medications, antidiarrheal medications may also be exposed to high levels of aluminum.”

 

 Aluminum-hydroxide in vaccines causes serious health problems

 

“A new disease has been identified, first in France, called macrophagic myofasciitis (MMF). The condition manifests with spread out muscle pain and chronic fatigue. One third of the patients develop an autoimmune disease, such as multiple sclerosis (MS) or amyotrophic lateral sclerosis (ALS or Lou Gehrig’s disease). Even if they don’t have an obvious autoimmune disease, most of them are part of a subgroup called HLADRB1*01 that puts them at risk of developing polymyalgia rheumatica and rheumatoid arthritis.”

 

Doctors have identified that the aluminum-hydroxide in the vaccines stays at the site of the injection for years. The whole time it is there, it is stimulating an immune response. Which is exactly why the vaccine makers include it in the vaccine, so that the immune system will react more strongly to the virus or toxoid. But switching the immune system on without turning it off is not good for the body. This appears to be what causes the chronic fatigue seen in MMF.2″

 

 

In studies they were able to reproduce the MMF lesions in rats, and concluded that they were caused by the aluminum-hydroxide in the vaccines, and the ongoing local immune reaction.3 The vaccines in question for this particular study were hepatitis B, hepatitis A and tetanus.

 

 …In another study of 92 MMF patients, eight had a demyelinating central nervous system disorder. The myelin sheath is the protective covering that surrounds and insulates nerves. When myelin is damaged, the nerves eventually become damaged, leading to disrupted transmission of signals within the nervous system.4 The MS diagnosis was definite in five out of seven cases, and probable in two out of seven.5 Based on the association with MMF and MS disorders they suggested that deltoid muscle biopsies be done in cases of MS to look for MMF.

 

 MMF has now been identified in children, and was characterized by motor delay, hypotonia (diminished muscle tone), and failure to thrive. They concluded that MMF should be considered in the evaluation of children with failure to thrive, diminished muscle tone, and muscle weakness.

 

…So what can we conclude from all of this? Science has proven that the following conditions may all be caused by the aluminum-hydroxide in vaccines: Chronic fatigue, Multiple sclerosis , Lou Gehrig’s disease, Demyelinating central nervous system disorders, Plymyalgia rheumatica and rheumatoid arthritis, Motor delay, Hypotonia or diminished muscle tone, Failure to thrive, Apoptic neurons, which are self-destructing neurons in the lumbar spinal cord, Neuron loss in the lumbar spinal cord.”

 

 Its Not Just The Mercury: Aluminum Hydroxide In Vaccines

 

“Aluminum is known to be associated with degenerative, fatal neurological conditions like Parkinson’s, ALS (Lou Gehrig’s) and Alzheimer’s…

   
The reason that aluminum is in our vaccines is because it is an adjuvant
 
Generally speaking, the way vaccines work is that they contain a virus and substances called ‘adjuvants’ (like mercury and aluminum) that kick the immune system into high gear so that they go on the hunt for the viruses, eat ‘um up, and create antibodies against further infection. 
 
In people with typical immune systems, the body then stands down from high alert. But in some people, it doesn’t, and the immune system begins to behave like early 20th century Germany and attacks what ever is in sight. The result, autoimmune disorders. 
 
A few examples of autoimmune disorders: When the immune system attacks the connective tissue, you get arthritis, when it attacks the mylon sheath around the nerves, you get Guillain-Barré Syndrome (a known side effect of the flu shot that causes paralysis), and when it attacks the pancreas you have Type 1 Diabetes. And on and on. 
 
…it has taken decades for it to be properly medically investigated, and for the autoimmune features of the disorder (i.e. cytokines in the brain causing swelling leading to cognitive dysfunction) to be recognized. (Which is why even mild anti inflammatory agents like fish oil improve communication skills of so many people with autism, and why parents report that children’s autistic symptoms seem to improve when their kids are sick.) 
  
…Similar adjuvants are used in the following vaccines, according to Shaw’s paper: hepatitis A and B, and the Pentacel cocktail, which vaccinates against diphtheria, pertussis, tetanus, polio, and a type of meningitis.”

     

 Aluminum toxicokinetics regarding infant diet and vaccinations.

 

  “Some vaccines contain aluminum adjuvants to enhance the immunological response, and it has been postulated that this aluminum could contribute to adverse health effects, especially in children who receive a vaccination series starting at birth. The pharmacokinetic properties and end-point toxicities of aluminum are presented. In assessing the relevance of dietary and medical aluminum exposure to public health, we estimated infant body burdens during the first year of life for breast milk and formula diets and for a standard vaccination schedule. We then compared those body burdens with that expected for intake at a level considered safe for intermediate-duration exposure. The methodology blends intake values and uptake fractions with an aluminum retention function derived from a human injection study using radioactive 26Al. The calculated body burden of aluminum from vaccinations exceeds that from dietary sources, however, it is below the minimal risk level equivalent curve after the brief period following injection.”