The Vaccine Hard Sell at Pediatrics

The Vaccine Hard Sell at Pediatrics-Age of Autism

A Shot of Reality
By Michael Wagnitz, B.S.
 
As a chemist with 27 years of experience evaluating material for heavy metals, I find it unfortunate that the journal Pediatrics has allowed Dr. Paul Offit to repeat misinformation  regarding the use of neurotoxic metals in vaccines. He scolds Dr. Bob Sears for not giving the proper scientific credit to the paper, “Weight of Evidence Against Thimerosal Causing Neuropsychological Deficits” (1), published in the NEJM.  Let’s take a look at the quality of this paper starting with the impartiality of the authors:

Dr. Thompson – the lead investigator – is a former employee of Merck.

Dr. Marcy has received consulting fees from Merck, Sanofi Pasteur, GlaxoSmithKline, and MedImmune.

Dr. Jackson received grant money from Wyeth, Sanofi Pasteur, GlaxoSmithKline, and Novartis. He received lecture fees from Sanofi Pasteur and consulting fees from Wyeth and Abbott. Currently, he is a consultant to the FDA Vaccines and Related Biological Products Advisory Committee.

Dr. Lieu is a consultant to the CDC Advisory Committee on Immunization Practices.

Dr. Black receives consulting fees from MedImmune, GlaxoSmithKline, Novartis, and Merck, and grant support from MedImmune, GlaxoSmithKline, Aventis, Merck, and Novartis.

Dr. Davis receives consulting fees from Merck and grant support from Merck and GlaxoSmithKline.

(The above information was included in the fine print of the published article)

The article states that any child with a preexisting neurological condition was eliminated from the study. Isn’t this what the study was supposed to examine, whether thimerosal causes neurological damage? These preexisting conditions included encephalitis and meningitis. The possibility that thimerosal might cause these conditions was eliminated from consideration.
 
Children were eliminated for other reasons from the study. One group excluded was children whose birth weight was under 2,500 grams, or 5.5 pounds. The number of  babies eliminated because of this was not reported. Babies of this weight are not rare and they are not excluded from any  vaccine. In fact, in a study published last year in Pediatrics, it was shown that low weight babies had a much higher rate of autism (2). In the end, only about 30% of the original study participants remained. The authors seemed to weed out anyone who didn’t fit their desired conclusion. Offit says (and I quote), “It is hard to imagine a better conceived, better designed study on the subtle effects of mercury poisoning”. No Offit, it’s hard to imagine a better conceived and better designed study to obfuscate the issue concerning the safety of thimerosal.

Offit tells us how aluminum in babies formula and breast milk dwarfs the amount in vaccines. What he doesn’t explain is that aluminum is only dangerous once it’s in the bloodstream. Aluminum is not absorbed through the gut. It is 100% absorbed through vaccination. He ignores the paper published in 2007 linking aluminum in vaccines to Gulf War Syndrome (3) . If it can harm healthy, adult, combat ready soldiers, at a lower dose per body weight, what is it doing to newborns?

Here is one subject Offit never touches; multi-dose vaccine vials, including current versions of the flu, tetanus and meningococcal vaccines, contain 50,000 ug/l of Hg, a level 250 times higher than what the EPA classifies as hazardous waste (4). All these vaccines are recommended for children. Primates exposed to injected ethylmercury from vaccines, as opposed to equal doses of ingested methylmercury, end up with twice as much Hg++ deposited in the brain (5). This form remains permanently trapped and has been identified as the primary toxic agent in degenerative brain diseases (6). State of the art research has shown us that autism is a degenerative brain disease (7).

Parents understand the difference between truthful information from honest, caring professionals like Dr. Bob Sears and the aggressive, bullying tactics that Offit and others are trying to sell them. The cat is out of the bag and it’s not going back in.

Full Article

Building a Baby from the Foundation Upwards:

                                Building a Baby from the Foundation Upwards:

Neurological Issues Can Start From Conception If the Conditions Are Right

 

 Genetics, nutrition, environmental toxins, vaccines, and their combined impact on the immune system, can all play a role in Autism spectrum disorders. Think of it as a pyramid with the child at the top and all the damaging features underneath starting in utero. Some children don’t need vaccines to tip them over the edge if the child was born at the top or near the top of the pyramid to begin with. Other children who are close to the top, all they would need is a major mineral imbalance combined with one or two vaccines to tip them over the edge.

Think about this quote in the United States Senate on May 12, 1999 by Dr. Bonnie Dunbar, a Professor of Immunobiology:

“I would challenge any colleague, clinician or research scientist to claim that we have a basic understanding of the human newborn immune system. It is well established in studies in animal models that the newborn immune system is very distinct from the adolescent or adult. In fact, the immune system of newborns in animal models can easily be perturbed to ensure that it cannot respond properly later in life.”

 

Children who have gone into an immediate regressive autism after vaccines are the ones who may have been able to cope, and not tipped over the edge, if they had more time to mature their immature immune systems.  Others, without vaccines, were just too close to the top of the pyramid at birth or in utero.

 

Birth Control Pill Use:

 

Anything that affects hormones enough to stop a lining shedding could cause issues. The use of hormones disrupts mineral balance, and further disturbs the normal running of metabolic pathways. If enough are disturbed, then it could contribute to an unstable foundation for a baby. The pill can strip out magnesium, zinc, B6, folic acid and EFA’s from the body.

The pill can skew the hormone system long-term and changes vascular circulation permanently, and further trashes the body’s supply of magnesium, zinc, B vitamins, folic acid and essential fatty acids. All these things lay the foundation for a pregnancy in which fetal nutrient absorption comes from a deficit position right at the outset.

Dr. Ellen Grant wrote a book called Sexual Chemistry which explains it. She was involved in the original large trials on what the pill does to the body.

 Also:  

…”Our studies in 1981 and 1989 found significantly higher concentrations of copper and cadmium in hair in dyslexic children compared with matched controls.1,2 Sweat zinc was severely deficient in the dyslexic children, being 66% lower than that for control children. However, the control children in 1989 had much lower average zinc level than the children tested for laboratory reference range purposes 10 years before in 1979.2,3 Zinc deficiency allows accumulation of toxic metals which may be important causes of the increase in autism, asthma, dyslexia and hyperactivity in the past few decades.4,5

Biolab Medical Unit offers analyses of all toxic metal levels in blood, metal sensitivity tests and the effects of toxic metal substitution on proteins and some binding sites.6,7 Dr John McLaren- Howard presented the results of testing 61 autistic children at a Biolab Workshop for Doctors in June 2004, as he was attempting to find out which nutritional tests should be recommended. Among the 42 boys and 19 girls most were deficient in zinc and magnesium. Many were also deficient in copper, chromium, manganese, molybdenum and B vitamins. Therefore, essential fatty acids were also likely to be deficient. 16 children had DNA-adducts in leucocytes to malondialdehyde, 12 to cadmium, 9 to nickel. Three of the 61 children had DNA-adducts to mercury and one had DNA- adducts to lead. 37 children had antigliadin IgG antibodies, while 30 children had malabsorption detected by a D-xylose test. Malabsorption was most common in those with Asperger’s type syndrome, 16 out of 18 children.

The zinc and magnesium lowering effects of maternal use of progesterones and oestrogens, parental smoking and alcohol use and parental dental mercury and other dental metal levels like nickel and tin, need to be looked at in larger studies. Mercury is a toxic metal whether it is in dental amalgams or in vaccines. If 5% of autistic children show evidence of signs of mercury exposures, this still means large numbers of children have been adversely affected. Clearly the increasing incidence of childhood diseases needs proper biochemical scientific investigations.”

  
Environmental:

 

Pollutants ‘in children’s blood’  

Toxic metals for vegetable fruit sprays, like Arsenate of copper and Arsenate of Mercury, DDT used to be used. Now, sprays are different, but are they really better? Our stolen future  and Chem Trails.  

 

Vaccines:

 

The vaccine becomes the bullet for many children. They start out seemingly healthy, even with perhaps a shaky foundation. But once the bullet (vaccine) is injected, they begin to spiral downwards. Symptoms are pathway dysfunction, not illness.

 

Diet and Nutrition/Minerals:

 

Copper and zinc are important because if they are out of sync the enzymes that create neurotransmitters, that the brain cells use to transmit their messages from one brain cell to another, won’t work properly. B6 works with those. Proper balance is what is needed because if you get the copper and zinc right, you can modulate the brains regulation of mood and reaction to stress. These enzymes also need B6; as B6 often helps in treating depression. In women, low zinc and high copper can be linked to ‘rage’ episodes during PMS.

Suphur has a key interaction with selenium. Selenium is good for skin, hair, nails, to build certain amino acids in the cells and brain, and make sulfonated compounds for the joints.  When there is a deficiency, there is a reduction in the activity of the enzyme gluthathione peroxidase. This results in reduced immune function, which has its greatest effect on the helper T dependent cells,  and production of Ig.M is impaired. IgM is one of the front line Th1 antibodies which are made in the early stages of an infection. Children suffering from malnutrition fail to grow when given a recuperative diet, if it remains selenium deficient because selenium is necessary for protein synthesis. While it protects against the toxic effects of the pollutant cadmium, and mercury from all sources, it also increases the effectiveness of vitamin E, and it reduces the chances of all types of cancer. In communities where selenium intake is low, the cancer rate is high.

Maternal selenium nutrition and neonatal immune system development.

Skeletal muscle disorders associated with selenium deficiency in humans.
Deficiency in selenium or Vitamin E also shows reduced natural killer cell activity. With regard to the enzymes; Glutathione is essential for:
-detoxification and liver function
-effective immune response
-antioxidant defense
-male fertility (low sperm counts)

-blood sugar metabolism
-blood pressure regulation
-tumor inhibition
-inhibition of thrombus formation in diabetes
-prevention of neurodegenerative disorders like Alzheimer’s disease, Parkinson disease, Huntington’s chorea, stroke and brain trauma.

Effective Glutathione is important for T cell proliferation, development of large CD8+ T cells, cytotoxic T cell activity and production of CD16+ natural killer cells. Glutathione protects and repairs liver tissue under severe acute and chronic alcohol exposure.

Selenium protects against the toxic effects of the pollutants cadmium, and mercury. It helps prevent chromosome breakage in tissue culture. It is the basis of the unique enzyme system Glutathione peroxidase, which destroys peroxides before they can attack cellular membranes, while the vitamin E acts within the membrane itself preventing the oxidation of membrane lipids.

When discussing epigenetics; they know demethylation is carried down through the generations and they know it can be reversed.

 This is the list of tests a DAN doctor may perform:

*Complete blood count w/ differential and platelet count
*Serum metabolic assay (complete)
*Thyroid profile (T3, T4 and TSH)
*Amino acid profile (plasma)
*Organic acid profile (urine)
*Ammonia level
*Lactic acid level
*Pyruvic acid level (pyruvate)
*Heavy metal profile (lead, mercury, arsenic and cadmium), blood
*Vitamin A level
*Zinc and copper (serum)
*Measles, mumps and rubella antibody IGG titers
*Fragile X
*IgG, A, M, E
*IGG subclasses
*T cell function tests
*Myelin basic protein and neural axon filament antibodies

 But other minerals should be tested as well such as:

*Magnesium

*Chromium

*Selenium

*Aluminum

*Dysbiosis  

 

Immunologist have begun to test for a genetic variant in an enzyme called  Methylenetetrahydrofolate reductase (MTHFR) and  Glutathione.  
METALLOTHIONINE PROTEIN DYSFUNCTION
Diseases that can occur because of MT protein dysfunction include:
· Psoriasis and eczema
· ADD and ADHD
· Autism
· Schizophrenia and Obsessive Compulsive disorder
· Anorexia
· Alcoholism
· Chronic fatigue syndrome
· Alzheimer’s

Metallothionine protein disorder is thought to be a genetic defect involving more than one gene. This disorder results in a decreased ability of the MT protein to function normally. Metallothionine protein helps regulate zinc and copper levels in the blood,  withdrawal heavy metals as they enter the body, help development and continued functioning of the immune system, help development and pruning of brain cells, (neurons), help prevent  yeast overgrowth in the intestines, aid in the production of enzymes that break down casein and gluten, aid in the production of hydrochloric acid by stomach cells, help taste and texture discrimination by the tongue, and aid in the behavior control and development of memory and social skills.

In 2000, William Walsh, Ph.D. of the Pfeiffer Treatment Center discovered that the majority of autistic patient’s exhibit MT dysfunction and the classic signs of autism can be explained by a MT dysfunction. There are four primary types of MT proteins and each has an important role in the body.

MT-I and II are present in all cells throughout the body. They regulate copper and zinc, are involved in cell transcription, detoxify heavy metals, play a role in the immune function, and are involved in a variety of G.I. tract functions.

MT-III is found primarily in the brain and functions as a gross inhibitory factor in the brain. MT-III is located primarily in the central nervous system with small amounts present in the pancreas and intestines. It plays a major role in the development, organization and programmed death of brain cells.

MT-IV is found in the skin and upper G.I. tract. They help regulate stomach acid pH, taste and texture discrimination of the tongue and help protect against sunburn and other skin traumas.

Theories for the Pathophysiology of Autism:

Brain autoimmunity
Deficits in sulfur metabolism
Abnormal liver detoxification
Gastrointestinal abnormalities

 

Possible Causes of Immune Injury or Alterations:
 
 

 

A genetic weakness (C4B null allele) and/or predisposition, combined with one or more of the following:
1) Shortened or absent breast-feeding preventing the full development of transferred cellular immunity. (Fudenberg)

2) Early gluten (usually wheat) introduction prior to one year of age. Wheat has been genetically manipulated in the last 100 years to increase the gluten content.

3) Early use of cow’s milk or casein based formulas. (Allergenic and altered)

4) Immunizations with live viruses, especially the MMR after 1978. There is frequent regression after the MMR vaccine that has been observed and published (Wakefield). Other vaccinations and the resulting effects on interleukin or autoimmunity. (Singh) DPT (especially if whole cell pertussis is used) and HepB (not live viruses) may also play a role in immune alterations.

5) Use of antibiotics and resulting yeast and pathogenic bacteria infection or overgrowth, with resulting immune modification and toxic exposure. (Shaw, Fudenberg, Wuepper)

6) Maternal allergy, chronic fatigue syndrome, or leaky gut problems that caused the child to be pre-sensitized in the womb. (Fudenberg)

7) Leaky gut from any number of the above or also related to parasites or GI infections in the child that allow gluten and casein to leak into the bloodstream. Once in the body, the body alters them into toxic substances. Sucrose (table sugar) also leaks in and it is an abnormal sugar in the blood stream that causes a host of problems.

8) Defect in the detoxification pathway of the brain, Phenol Sulfur-Transferase or PST enzyme defect. Inadequate intake of sulfur compounds. (Rosemary Waring, Birmingham University, England).

9) They develop autoantibodies to Myelin Basic Protein (Singh, Fudenberg, and Gupta) and other brain components. Measles is known to induce MBP antibodies. I’ll talk about this a lot more later.

10) Defective cellular immunity, especially in the NK cell activity towards self and pathogens. (Fudenberg, Gupta). And the probable elevation of Interleukin-2 and 12.

 

Jeff Bradstreet, M.D., FAAFP
The International Child Development Resource Center  
Let’s break each one above down…

1. Breast milk creates the right probiotics which absorb minerals the right way, and provide the foundation for cellular immunity and nutrient absorption. The gut makes up 70 % of the immune system.  It also plays a role in e-coli endotoxin production.

2. It has nothing to do with the gluten. Salivary fluid has an enzyme in it, to break down grains when the molar teeth cut. Celiac for example isn’t caused by too much gluten. It’s caused by lack of the enzyme opening the pathway to those with epigenetic susceptibility. Before 1900’s, celiac was pretty much unheard of. More gluten isn’t good for some people.

3. Unpasteurized animal milk worked well versus pasteurized.

4.  True, but you only know what you have looked at. What about the others?

5.  Antibiotics cause immune modification all on their own, not necessarily as a result of the resulting yeast and pathogenic bacteria infection and overgrowth. What about e.coli?

6.  What caused the maternal allergy? If you look at minerals and other, you may be able to eliminate the allergy.

7.  Leaky gut would not be a problem if the foundation was laid right and a change in nutrition better understood.

8.  If you have an inadequate intake of sulfur compounds and/or an inadequate intake of other minerals such as magnesium, zinc, selenium.

9.  That is not the cause, but the end result. The cause needs to be worked out.

10.  See # 9.

Fever Reducers
Fever reducers lower glutathione levels. When glutathione levels are reduced, you increase the level of the hormones. They also suppress the immune system further.

 Also See:

 Autism – the vaccine connection 
  
The lutein free diet, a treatment option for autism. Review of lutein as it relates to autism. 
 
The Thoughtful House (2005 Conference)

 

Antibiotics and Fever Reducers

Antibiotics cause a stall out or dying off of intestinal flora, which kills the e.coli in the gut. When killed,  the endotoxin located in the e.coli’s outer coating is released, which often causes a cascade of health issues to result. Endotoxemia affects the glutathione biochemical pathways, which are also a key component of the immune system, among other vital functions.

 

“Antibiotics disrupt the normal population of beneficial microbes/bacteria in the gastrointestinal tract of all Human/animals. These beneficial bacteria are the first fine of defense against most diseases, without them the Human/animal is more susceptible to other infections. Antibiotics depress the immune system by decreasing the number of circulating white blood cells. This lowers the Human/animal’s ability to fight infections. Some antibiotics, such as chloramphenicol, can cause irreversible damage to the bone marrow. Many bacteria develop resistance to the effects of antibiotics. This resistance can be passed to other bacteria, The concern is that if humans are exposed to resistant bacteria then the use of antibiotics may be ineffective in treating any resulting disease.”  – Richard J. Holliday, DVM

Link found between use of antibiotics in infants and asthma

 2007 Canadian Report:

Taking a single course of a certain type of antibiotic gives rise to high levels of antibiotic resistant bacteria in the mouth, an effect that lasts for at least half a year, a new study has found.

…even after a single – and short – course of antibiotics, a person could spread resistant strains of bacteria to close contacts within a household or a hospital for months.

 

Antibiotics in Vaccines

 Neomycin

Streptomycin

Gentamicin Sulfate 

 Vaccines:

Polio

Single mumps

Single Rubella

MR

MMR

Flu

Single Measles

Pentacel Brand 

Rabies

  Fever Reducers:

 Antipyretics, also known as fever reducers, lower the immune system which can set babies and children up for potentially worse problems.  

Paracetamol (fever reducer) may prolong infection and reduce the antibody response in mild disease, and increase morbidity and mortality (death) in severe infection.

 

If you can get rid of the vaccine pyrogens that are causing the temperature, it will come down on its own, and the quickest way to do that is vitamin C (sodium ascorbate). Diarrhea is a sign of gut dysbiosis and is a sign there is a significant immunological disturbance in the body. 70% of the immune system is located in the gut, and if you mess with that, the gut allows vital immunological resources to work elsewhere. Foul smelling diapers are also a very common with vaccine reaction. It’s the most obvious indicator that the body is going haywire.

 

  Pregnant Women Who Take Acetaminophen Could Raise Asthma Risk in Their Kids

 

The findings were presented here at the annual meeting of the American Academy of Allergy, Asthma & Immunology (AAAAI).

So what could be happening? While no one knows for sure, Perzanowski says that acetaminophen use may deplete the lung of an antioxidant called glutathione. Researchers think glutathione, which is found in the lining of airways, may play an important role in preventing damage to the lungs.

 

Fever is often a beneficial host response to infection, and moderate fever improves immunity. Therefore, it may not be a good idea to give drugs that reduce temperature to patients with severe infection. I have recently reviewed 1 the results of 9 controlled trials in mammals of the effect of paracetamol or aspirin on mortality or virus excretion. Four trials found that aspirin increased mortality in bacterial or viral infection. Viral shedding was increased by paracetamol or aspirin in 3 studies, possibly increased in one, and not affected in two (one used only pharyngeal washings, and one had only 9 subjects in the aspirin and placebo groups). One study found that antibody production was impaired by both paracetamol and aspirin, but no effect on antibody production was detected in the study with only 9 subjects in the aspirin and placebo groups. This evidence suggests that aspirin and paracetamol increase mortality in severe infection, and that they may prolong the infection and reduce the antibody response in mild disease. 
….It should be explained to parents that fever is usually a helpful response to infection, and that paracetamol should be used to reduce discomfort, but not to treat fever.

 

 

 The Neurologic basis of fever, Saper, Clifford B. The New England Journal of Medicine, vol. 330, No. 26. June 30, 1994,  Page 1880:

“The elevation of body temperature by a few degrees may improve the efficiency of macrophages in killing invading bacteria, whereas it (fever) impairs the replication of many microorganisms, giving the immune system an adaptive advantage. 
 
There is a simultaneous switch from the burning of glucose, an excellent substrate for bacterial growth, to metabolism based on proteolysis and lipolysis. The host organism also becomes anorexic, which minimizes the availability of glucose, and somnolent, which reduces the demand by muscles for energy substrate. During the febrile response, the liver produces proteins known as acute-phase reactants. Some of these proteins bind divalent cations, which are necessary for the proliferation of many microorganisms.  
 
The net effect of the metabolic responses activated during fever is to give the host organism an adaptive advantage over the invader.”

 

 Antipyresis and Fever, Barbara Styrt, MD, Barrett Sugarman MD. Arch Intern Med – Vol 150, August 1990, (Archives of Internal Medicine is a peer reviewed paper) Page 1589:

 

“Antipyretic drugs are effective in diminishing fever, but they have significant side effects and may suppress signs of ongoing infection.” 
 
“Antipyretic therapy should not be instituted routinely for every febrile episode but should be based on evaluation of relative risks in the individual case and reassessed if anticipated benefits are not achieved.”

Pg 1594: “The decision to administer antipyretics is frequently made without a documented rational. Current understanding of the mechanisms and pathogenesis of fever suggests that the febrile process has a role in host defense and that routine antipyretic therapy for fever is generally unnecessary and conceivably harmful. ”  
 
“Decisions to attempt suppression of fever should be based in infrequent indications arising in an individual case and should take into account the potential risks of antipyresis as well as its often questionable benefits.” 
 
Pg 1594: “In the vast majority of febrile illnesses, there is no evidence that fever is detrimental or that antipyretic therapy offers any significant benefit. Indeed, the limited information available on in vitro immune functions and in vivo outcomes would suggest that fever usually does more good than harm.”

 

“In treating fever “symptomatically” one should not lose sight of the fact that elevated temperatures, whatever their physiologic function, do serve as a signal both to the patient and to the caregiver. Nonspecific suppression of fever may deprive one of clues to a need for further diagnostic investigation, or for changes in therapy. Although these clues will often occur in the context of antipyretic use, one study has indicated that patients with a variety of bacterial infections receiving antipyretics experience a significant delay in institution of needed antibiotic changes.”

 

The American Journal of Medicine, volume 88, January 1990, Antipyretic Orders in a University Hospital Stuart N. Isaacs MD et al. Drug used: acetaminophen.

Page 31: “antipyretics are among the most widely used pharmacologic agents. Traditional rationales for their use include relief of discomfort associated with fever, prevention of febrile seizures, avoidance of the high metabolic costs of fever in those who are malnourished or who have cardiac or pulmonary disease, and lessening of brain edema in central nervous system disease or trauma. However, accumulating evidence indicates that fever may be an important defense mechanism.” 
 

 Acta Paediatr Jpn 1994 Aug; 36(4) 375 – 378. Risks of antipyretics in young children with fever due to infectious disease. Sugimura T, et al.

“The objective of this study was to determine whether paracetamol (acetaminophen) affects the outcome of children with fever due to bacterial infectious disease….. the data suggest that frequent administration of antipyretics to children with infectious disease may lead to a worsening of their illness.”

 

Eur J. Pediatr 1994, June; 153 (6) 394 – 402. Treatment of fever in childhood. 
Adam D, et al.

 “The most commonly used antipyretic drugs are acetylsalicylic acid (ASA) paracetamol (acetaminophen) and dipyrone (metamizol). …Paracetamol is the most common cause of acute hepatic failure… in the light of these findings, the extensive use of antipyretics drugs has been seriously questioned.” 
 
“Page 398: “Paracetamol has a pronounced liver toxicity. In the United Kingdom paracetamol is considered to be responsible for more cases of acute hepatic failure than any other cause.” 
 
Page 399 “the potential for toxicity of ASA and paracetamol, the two most extensively used antipyretics in the febrile child, underlines the constraints within which treatment decisions have to be made. The fact that both drugs are sold as “over the counter” products, while the medication of child fever often occurs without medical control, should be a matter of concern.

 

N Y State J Med. 1971; 71: 2747 – 2754.  Prnumococcal meningitis at Harlem hospital. Richter R W et al. 

 
Result: An increase of mortality with absence of fever in pneumococcal meningitis.

  

 “In summary, what does the evidence seem to indicate? Fever represents a universal, ancient, and usually beneficial response to infection, and its suppression under most circumstances has few, if any, demonstrable benefits. On the other hand, some harmful effects have been shown to occur as a result of suppressing fever: in most individuals, these are slight, but when translated to millions of people, they may result in an increase in morbidity and perhaps the occurrence of occasional mortality. It is clear, therefore, that widespread use of antipyretics should not be encouraged either in developing countries or in industrial societies.”

(Pediatr Vol 103, No 4, April 1999, 783-784 and 785-790. Infect Med 1999 16 (5):307.

 
Chickenpox
treated with Tylenol/Ibuprofen provokes bacterial skin infections into fulminant necrotising fasciitis.  This happens by prolonging inflammation and down regulating the immune system. It can no longer fully activate the adaptive arm of immunity either.

 

 The authors recently observed that frequent paracetamol use was positively associated with asthma and rhinitis in young adults. ….Their associations with national 1994/1995 per capita paracetamol sales were measured using linear regression. Paracetamol sales were high in English-speaking countries, and were positively associated with asthma symptoms, eczema and allergic rhinoconjunctivitis in 13-14-yr-olds, and with wheeze, diagnosed asthma, rhinitis and bronchial responsiveness in adults. The prevalence of wheeze increased by 0.52% in 13-14-yr-olds and by 0.26% in adults (p<0.0005) for each gram increase in per capita paracetamol sales. These ecological findings require cautious interpretation, but raise the possibility that variation in paracetamol usage may explain some of the variation in atopic disease prevalence between countries.

 

Asthma morbidity after the short-term use of ibuprofen in children


 
“However, the risk of an outpatient visit for asthma was significantly lower in the ibuprofen group; compared with children who were randomized to acetaminophen, the relative risk for children who were assigned to ibuprofen was 0.56 (95% confidence interval: 0.34-0.95). CONCLUSIONS: Rather than supporting the hypothesis that ibuprofen increases asthma morbidity among children who are not known to be sensitive to aspirin or other nonsteroidal antiinflammatory drugs, these data suggest that compared with acetaminophen, ibuprofen may reduce such risks. Whether the observed difference in morbidity according to treatment group is attributable to increased risk after acetaminophen use or a decrease after ibuprofen cannot be determined.”

 

 According to the FDA:
 
Safety Anaylasis of Acetaminophen   

Drugs with Limitations – limitations on their use (warnings, dose restrictions, monitoring):
Niaspan Extended Release Tablets (niacin)
Dantrium (dantrolene)
Tylenol (acetaminophen)
Normodyne (labetalol)
Cylert (pemoline)
Felbatol (felbamate)
Zyflo (zileuton)
Tasmar (tolcapone)
Trovan (trovafloxacin, alatrofloxacin)

  
What WHO has to say about Fever and antipyresis
 

 In addition to the probability that antipyretics may prolong the course of mild to moderate infectious illnesses, what other deleterious effects might they have? Russell et al. point out that little is known about the pharmacokinetics of these drugs in poorly or malnourished children. Even in developed countries, all available methods of antipyresis must be treated with respect. Warning labels became required for paracetamol recently and for aspirin in the more distant past. In addition to acute poisoning, the former has been implicated in the development of chronic renal disease, and perhaps liver failure, when repeatedly administered over prolonged periods of time . Perhaps more important is the fact that antipyretics mask symptoms or signs; children with pneumonia, for example, may not receive a proper diagnosis because their respiratory rate decreases (4) or because, when the body temperature starts to fall, the child may be considered to be on the way to recovery and thus needing no further observation. Finally, of course, the costs may consume a significant amount of resources that, in developing countries, could be better devoted to specific diagnosis and therapy.

Other potential benefits of reducing fever are sometimes cited to justify the use of antipyresis. A common assumption is that these drugs make patients feel better, but no clear evidence shows that this is so. Parents and physicians consistently cannot distinguish between the effects of placebo and paracetamol in most circumstances. Perhaps the exceptions are conditions accompanied by pain, for which the analgesic effects of the medication provide the benefit. When fevers rise above 39.5 oC, a reduction in body temperature is sometimes accompanied by an improvement in subjective symptoms, but this is inconstant, with young children seeming to benefit more than older children.

 The major problem when evaluating the subjective effects of antipyretics is that they have an enormous placebo value – as various studies have shown. Despite the firm belief in the effects of antipyretics, children do not feel any better, eat better, or become more active after their use than they do after they receive placebo. The argument that the use of antipyretics reduces the occurrence of febrile seizures also is not based on evidence: no studies have shown this to be true. Even in children with previous febrile seizures, the use of antipyretics has not been helpful. Some physicians believe that the response to antipyretics can be used to differentiate between bacterial and viral infections, with the latter responding more completely and promptly. Numerous studies have shown this to be a fallacy.

 

Overdose:
   

Acetaminophen overdose is the leading cause for calls to Poison Control Centers (>100,000/year) and accounts for more than 56,000 emergency room visits, 2,600 hospitalizations, and an estimated 458 deaths due to acute liver failure each year. Data from the U.S. Acute Liver Failure Study Group registry of more than 700 patients with acute liver failure across the United States implicates acetaminophen poisoning in nearly 50% of all acute liver failure in this country. Available in many single or combination products, acetaminophen produces more than 1 billion US dollars in annual sales for Tylenol products alone. It is heavily marketed for its safety compared to nonsteroidal analgesics. By enabling self-diagnosis and treatment of minor aches and pains, its benefits are said by the Food and Drug Administration to outweigh its risks. It still must be asked: Is this amount of injury and death really acceptable for an over-the-counter pain reliever?

 

According to the BMJ 2002;325:678 ( 28 September ) :

FDA fails to reduce accessibility of paracetamol despite 450 deaths a year. Confidential documents from the US Food and Drug Administration suggest that the agency has avoided a debate on tough new measures to reduce overdoses from painkillers to avoid offending the pharmaceutical industry. Ray Moynihan reports from Washington, DC  
 
” A confidential draft document reveals that the Office of Drug Safety also wanted the advisory panel to discuss whether the “maximum tablet strength should be decreased,” whether “combination products be reformulated without acetaminophen,” and whether there was “a need to standardize the various paediatric formulations.”  
 
The advisers never saw that draft, however, and none of these key options ended up being clearly presented to the committee by the FDA in the final list of questions they were to consider.  
 
…. “The committee would have preferred more focused questions,” he said.  
 
According to one FDA insider, the draft questions were dropped because senior FDA managers saw them as too offensive to Johnson & Johnson. Asked about this alleged corporate influence within the FDA, Dr Cantilena smiled and said he did not want to speculate.

The Neurologic basis of fever,Saper, Clifford B. The New England Journal of Medicine, vol. 330, No. 26. June 30, 1994, Page 1880:

 

“The elevation of body temperature by a few degrees may improve the efficiency of macrophages in killing invading bacteria, whereas it (fever) impairs the replication of many microorganisms, giving the immune system an adaptive advantage. 
 
There is a simultaneous switch from the burning of glucose, an excellent substrate for bacterial growth, to metabolism based on proteolysis and lipolysis. The host organism also becomes anorexic, which minimizes the availability of glucose, and somnolent, which reduces the demand by muscles for energy substrate. During the febrile response, the liver produces proteins known as acute-phase reactants. Some of these proteins bind divalent cations, which are necessary for the proliferation of many microorganisms.  
 
The net effect of the metabolic responses activated during fever is to give the host organism an adaptive advantage over the invader.”

 

J. Paediatr. Child health (1993) 29; 84 -85: Paracetamol: When, why and how much. Editorial

“in patients without heart and lung disease fever is harmful only at temperatures over 41 o C; such high termperatures are usually caused by heat stroke or brain injury, and they do not respond to paracetamol or aspirin.”  There is no evidence that antipyretics prevent febrile convulsions”

 

Eur J. Pediatr 1994, June; 153 (6) 394 – 402 Treatment of fever in childhood
Adam D, et al.

“The most commonly used antipyretic drugs are acetylsalicylic acid (ASA) paracetamol (acetaminophen) and dipyrone (metamizol). …Paracetamol is the most common cause of acute hepatic failure… in the light of these findings, the extensive use of antipyretics drugs has been seriously questioned.” 
 
“Page 398: “Paracetamol has a pronounced liver toxicity. In the United Kingdom paracetamol is considered to be responsible for more cases of acute hepatic failure than any other cause.” 
 
Page 399 “the potential for toxicity of ASA and paracetamol, the two most extensively used antipyretics in the febrile child, underlines the constraints within which treatment decisions have to be made. The fact that both drugs are sold as “over the counter” products, while the medication of child fever often occurs without medical control, should be a matter of concern.

 

Antipyretics appear to prolong illness by reducing the temperature, thereby disabling the body’s full ability to deal with whatever is the problem. In a nutshell, the lower the temperature, the longer the duration of illness. The higher the temperature, the shorter duration of illness. Immunologically, temperatures from infection are specifically designed to speed up and kick the immune system into gear, release cytokines and other immunological forces to deal with the problem. 

Tetanus

Tetanus vaccine is used as a ‘just in case’ scenario if the spores start replicating and producing a deadly toxin. This toxin can get into the bloodstream and then the central nervous system. The spores do not cause the disease; the toxin does. Tetanus can survive anywhere as a spore. The spore is incapable of causing illness in the presence of oxygen. Any wound that is getting a good supply of oxygen won’t allow the bacteria to thrive and begin to secret toxin. A minor wound like a scrape will be oxygenated just because it’s open to the air. A puncture wound should receive oxygen through circulating blood, so even puncture wounds shouldn’t be a problem for healthy children and adults with good circulation, as long as you clean them well. Burns and crushing wounds are more likely to become infected with tetanus, especially burns, since those types of injuries can destroy blood vessels in the area.

 

Tetanus was rare prior to the introduction of the tetanus vaccine. The decline of tetanus is attributed to proper wound management and sanitary conditions. If no vaccine was developed, cases would have declined regardless.  The CDC claims more than 1/2 the U.S. adult population is not protected against tetanus, yet where are the millions contracting tetanus today?  Where were the millions with tetanus before vaccination? I encourage you to look and try to find them but be warned, it will be like looking for a needle in a haystack. Universal tetanus vaccination, including making it mandatory for school entry across the country, is the biggest scam. No one can use the use the ‘herd immunity’ argument with tetanus since it’s not communicable. 

When a person gets tetanus from an injury (deep puncture wound that doesn’t bleed) and recovers, he is not immune. We can get tetanus repeatedly in our lives.  If the body can not build immunity from a natural toxin, how can we expect the vaccine to do that? 

 

A 1969 article from the New England Medical Journal, Volume 280, Number 11, March 13, page 570, is an interesting decline graph for mortality rates. It shows that the mortality (death) rate plummeted dramatically from 64/100,000 in 1900 to 8/100,000, in 1940.  By 1950, with most mothers still unvaccinated, it was 4.5/100,000. They say that it may have been the use of anti-toxin from 1923. Well, the antitoxin can kill all by itself, because it is made in horses, and has horrendous side-effects of its own. Some people treated with anti-tetanus toxoid, will die of the toxoid side-effects. There are plenty of people around in the USA who have never been vaccinated, including the Amish, who work with horses (horse manure is conductive to tetanus) and they haven’t died out as a community.

 

An interesting study in the American Journal of Public Health, August 1984, Vol 74, No 8, reported that in 1,900 adults over 20 years of age, the overall percentage immunized was 38.6%. So where are all the unimmunized adults dying from tetanus again?

 

According to Center for Disease Control (CDC) tetanus vaccine experts, The 1988 to 1991 serosurvey indicated that 20 per cent of children 10 to 16 years of age did not have a protective level of antibody. A 1979 study found that in a sample of 1900 adults over 20 years of age, only 386 per cent were fully immunised. If we extrapolate from that study alone, about 120 million or so citizens (60 per cent of 200 million) were unprotected yet virtually none of them was getting tetanus, let alone dying from it. Walene James, in her book Immunization: the Reality Behind the Myth, points out that in the United States in 1990 there were 25,700 cases of tuberculosis with 1800 deaths, tuberculosis therefore immensely outweighing tetanus as a cause of death. (Mothers of unvaccinated children who might be worried about them contracting tetanus because theyve just joined the pony club, take note!) In the United States, with an average of seven to 10 deaths per year from tetanus, there is a 180 to 260-times greater chance of dying from tuberculosis. In fact, since lightning strikes about 1800 people a year in that country, with an approximate mortality rate of 25 per cent (450 deaths), there is a 45-times greater chance of being killed by lightning than tetanus! (Ref: Tetanus Vaccination by Jason Sanders  Issue, 97 Page, 22)

  

The medical profession likes to state that a person does not acquire natural immunity to tetanus. Maybe they haven’t read that in 1975, in Dakar, in the proceeding of the 4th international symposium on tetanus, they talked about “latent” natural immunity causing reactions to primary immunization.  A study in JAMA Nov 19, 1982, Volume 248, No 19, showed a large number of the unvaccinated Amish showed serological evidence of immunity to both diphtheria and tetanus. There are several medical studies that tested unvaccinated people in various countries and found that they had anti-tetanus toxin antibodies. The WHO prefers to overlook this fact.

 

The tetanus vaccine takes 1-3 weeks to take effect, which is longer than the incubation period for tetanus.  The first 1-2 doses of tetanus vaccine does not confer any immunity, but simply “primes the immune system” to respond to future doses, according to the CDC.  If you are concerned about a specific injury/wound, the immunoglobulin confers immediate immunity for the duration of the incubation period. The immune globulin is blood/fluid which already contains antibodies to tetanus. The immunoglobin is also a risk since it’s a blood product so you would want to sure it was warranted.

 

“Tetanus immune globulin is not a vaccine. It is a preparation that is made from serum (part of the blood) from a person or animal (such as a horse) that contains antibodies against tetanus. It provides immediate, short-term protection against the disorder, but does not provide long-term immunization. It can be used when someone is believed to have been exposed to the bacteria…” …tetanus toxoid is of no value unless the individual has previously been vaccinated, since a primary antibody response takes at least 14 days, and the incubation period of the disease can be considerably shorter than this (three to 14 days).

“..tetanus toxoid is of no value unless the individual has previously been vaccinated, since a primary antibody response takes at least 14 days, and the incubation period of the disease can be considerably shorter than this (three to 14 days)..If you do decide to vaccinate your children with tetanus toxoid alone, there is no need to vaccinate until the child is old enough to walk around and navigate on his or her own (18 to 24 months), at which time the vaccine is far less likely to cause complications.”

 “The incubation period (for tetanus) varies from 3 to 21 days, usually about 8
days. In general the further the injury site is from the central nervous system, the longer the incubation period. The shorter the incubation period, the higher the chance of death.”

 

Gammaglobulin:

 

It’s not just antibodies because any blood product has to be treated because since blood contains a lot of things other than just red cells. Viruses and bacteria can get in there as its part of the immune system which is why they take the antibodies from blood.

A good read:

 

Normal serum contains IgG, IgM, and IgA antibodies, which are referred to as natural antibodies because they are induced without deliberate immunization and are independent of antigenic exposure. They are considered key to the immunoregulatory effects of immune globulin in immune-mediated disorders (Kazatchkine, 2001). Natural autoantibodies appear to be more polyreactive than immune antibodies; natural antibodies can frequently bind to different antigens (Kazatchkine, 2001). Natural autoantibodies can (1) bind to pathogens; (2) help remove senescent or altered molecules, cells, and tumors; (3) induce remyelination; and (4) inhibit the growth of autoreactive B-cell clones.

IVIG contains cytokines, antibodies of unclear clinical significance, perhaps neutralizing; interestingly, antibodies against granulocyte macrophage colony-stimulating factor, interferon, interleukin 1, and interleukin 6 in immune globulin have biologic activity in vivo (Kazatchkine, 2001). IVIG contains natural antibodies, accounting for some of its effects.

 The IVIG that is available contains complete IgG molecules. The IgG subclasses match those in normal human serum. Most preparations contain trace amounts of IgA, which can sensitize IgA-deficient persons during long-term treatment. Immune globulin also contains trace amounts of cytokines, soluble CD4, CD8, and HLA molecules.

 

Prevalence of hepatitis C virus in plasma pools and the effectiveness of cold ethanol fractionation.

 

Screening blood donations for antibodies against hepatitis C virus (HCV) greatly reduces the risk of transmitting HCV by transfusions. However, despite such screening programs, plasma pools still contain a high percentage of HCV ribonucleic acid as determined by polymerase chain reaction. This result would not be alarming if the procedures for producing blood products included steps to inactivate or remove HCV. Although this appeared to be the case for all blood products, such as coagulation factors and most immunoglobulins, which are subjected to an inactivation step, the effectiveness of the cold ethanol fractionation process still needed to be determined. In validation experiments using bovine viral diarrhea virus as a model virus for HCV, we demonstrated that the Cohn-Oncley cold ethanol fractionation process neither inactivated nor removed this virus sufficiently. Our observations may help to explain how HCV was transmitted to a number of recipients of intravenous immunoglobulin.

 Tetanus Vaccination by Dr Mendelsohn MD (The People’s Doctor Newsletter 1976-1988)

1) Scientific evidence shows that too—frequent tetanus boosters actually may interfere with the immune reaction.

2) There has been a gradual retreat of even the most conservative authorities from giving tetanus boosters every one year to every two years to every five years to every 10 years (as now recommended by the American Academy of Pediatrics), and according to some, every 20 years. All these numbers are based on guesses rather than on hard scientific evidence.

3) There has been a growing recognition that no controlled scientific study (in which half the patients were given the vaccine and the other half were given injections of sterile water) has ever been carried out to prove the safety and effectiveness of the tetanus vaccine. Evidence for the vaccine comes from epidemiologic studies which are by nature controversial and which do not satisfy the criteria for scientific proof.

4) The tetanus vaccine over the decades has been progressively weakened in order to reduce the considerable reaction (fever and swelling) it used to cause. Accompanying this reduction in reactivity has been a concomitant reduction in antigenicity (the ability to confer protection). Therefore, there is a good chance that today’s tetanus vaccine is about as effective as tap water.

5) Until the last few years, government statistics admitted that 40 percent of the child population of the U.S. was not immunized. For all those decades, where were the tetanus cases from all those rusty nails?

6) There now exists a growing theoretical concern which links immunizations to the huge increase in recent decades of auto—immune diseases, e.g., rheumatoid arthritis, multiple sclerosis, lupus erythematosus, lymphoma, and leukemia. In one case, Guillain—Barre paralysis from swine flu vaccine, the relationship turned out to be more than just theoretical.

In preparing my courtroom testimony on behalf of a child who allegedly was brain—damaged as a result of the DPT (diphtheria, pertussis, tetanus) vaccine, I reviewed the prescribing information (package insert) for the Connaught Laboratories product which was administered to this child. The 1975 and 1977 package insert information which measured seven—and—a—half inches long listed three scientific references in support of the indications, contraindications, warnings, cautions, and adverse reactions to this vaccine. By 1978, the length of the insert had grown to 13 1/2 inches, and the number of scientific references had increased to 11. By 1980, the package insert was 18 inches long, and the references numbered 14. Of those newly—added references, seven (three from U.S. medical journals and four from foreign medical journals) dealt specifically with reactions to the tetanus DPT portion of the (toxoid) vaccine.

The Journal of Allergy and Clinical Immunology, 1973, carried an article entitled “Hypersensitivity to Tetanus Toxoid,” and in a volume entitled “Proceedings of the II International Conference on Tetanus” (published by Hans Huber, Bern, Switzerland, 1967), an article appeared entitled “Clinical Reactions to Tetanus Toxoid.”

 

Basics:

 

1. A wound that bleeds can not grow tetanus 
 
2. Tetanus vaccine creates no reaction in the body for 3 weeks while tetanus grows within 10 days (but never in a wound that bleeds!) 
 
3. The body can not build immunity to the poisons nor the vaccine 
 

4. Children do not get tetanus. Their circulatory system is designed that way. (Only exception is in Africa where the umbilical stump is covered with mud.)

 

Health Measures-

 

-Use hydrogen peroxide. It cleans out the wound and the bubbles provide the oxygen needed.

– Let the wound bleed.

 

Immunity wanes after 10 yrs in most people and rare cases of fully immunized persons contracting and dying from tetanus have occurred. Tetanus is a clinical diagnosis and laboratory confirmation of infection is only found in about 30% of cases. The organism can be isolated in those without tetanus as well.
Overuse of the vaccine can result in hypersensitivity to tetanus and more severe infection-as documented in those with recent and/or over-frequent booster doses.

References and some good reads:

 

Immunity to tetanus: tetanus antitoxin and anti-BIIb in human sera.

Severe tetanus in immunized patients with high anti-tetanus titers

 

Relation between protective potency and specificity of antibodies in sera of tetanus immunized individuals

 

Response to single dose of tetanus vaccine in subjects with naturally acquired tetanus antitoxin 

 

Naturally acquired tetanus antitoxin in the serum of children and adults in Mali

 

Naturally acquired immunity to tetanus toxin in an isolated community

 

New concepts on tetanus immunization: naturally acquired immunity

 

HCG in the Tetanus vaccines?

 

This issue was raised by a Roman Catholic priest in Mexico. He stated that many of the vaccinated women were miscarrying or could no longer conceive. The vaccine was tested by three groups and found to have had hcg in it. Women in other countries had the same thing happen. WHO got involved and shoved it all under a rug and denied everything. But think about it…if the focus was on tetanus protection for all of the people, why were only woman getting vaccinated? The 1995 BBC Horizon program was called “The Human Laboratory”, and was never shown in USA.

 

The same BBC documentary reported that women in the Philippines and Mexico have also been used as guinea pigs for a new experimental pregnancy vaccine. The HCG vaccine makes a woman’s body reject new pregnancies. …, it has been administered, without the consent or knowledge of patients, as a “piggyback” vaccine in a series of tetanus vaccine programs.
…But when women who had recently received the “tetanus vaccine” began having an inordinate number of miscarriages, this bureaucratic curiosity turned into charges of conspiracy. Subsequent lab tests of the tetanus vaccine confirmed it had indeed been laced with an HCG vaccine.

 Subacute tetanus:

 

The clinical recognition of subacute tetanus.

The clinical features of a modified form of tetanus, termed ‘subacute tetanus’, occurring in non-immune patients are presented as manifested in five patients. Subacute tetanus has a good prognosis and favourable outcome. Trismus and abdominal rigidity may be minimal or absent. Nocturnal, brief generalized muscle spasms, palpably contracted sternomastoid muscles and spastic limbs are common features of the disease. The pathophysiology of the nocturnal muscle spasms requires elucidation.

Now compare it with this: Tetanus of immunized children

Five children aged five to 15 years contracted tetanus in Finland between 1969 and 1985, together with 101 adults. Four of the five had been adequately immunized against tetanus. The clinical picture of tetanus was mild or moderate, and none of the children needed respirator treatment. Epilepsy, meningitis and psychogenic symptoms were considered in the differential diagnosis. The course of tetanus in immunized patients is atypical and often benign, but the diagnosis is problematic–in contrast to affected children in developing countries, whose populations are not adequately immunized and where neonatal tetanus is common and often fatal.

It is mainly elderly people who die from tetanus. There is evidence that suggests that poor nutrition and lifestyle habits that impedes the immune system, which is connected to susceptibility, and usually in tandem with the age factor. Improved wound care has also greatly improved from the early 19th century.

 


Vitamin C and immunity:

The small minority of people who develop tetanus from trivial wounds are and the statistics are suggestive likely to be immune deficient, either because of old age, chronic ill-health, poor diet or drug taking (I include smoking and heavy drinking in this category) and most likely a combination of these factors. Many elderly people, as a result of poor appetite, have a diet lacking in essential vitamins and minerals. The same goes for intravenous drug users, another group prone to tetanus.

Linus Pauling, double Nobel Laureate scientist and expert on vitamin C, believed sub-clinical scurvy from vitamin C deficiency was widespread amongst senior citizens, making them prone to many illnesses. Vitamin C is a nutrient that is critical for immunity, so it should perhaps come as no surprise to learn it can be specifically curative. Doctor Fred Klenner, a North Carolina physician, outlined in various papers published from 1948 to 1974 his success with using intravenous mega-doses of ascorbate to deactivate tetanus spores and their toxin. This makes sense, because vitamin C removes toxins from the bloodstream while also enhancing white blood cell activity. In addition, since vitamin C is vital to collagen formation and has been proven to speed wound healing time, it is possible it also helps the body isolate and contain tetanus at the wound site. (Wounds can apparently break down if the body lacks vitamin C in the tissues.) Perhaps this is one reason why smokers may be a little more prone to tetanus, since they are known to have less vitamin C in the body. Vaccine researcher Hillary Butler says she has personally known only two people who contracted tetanus and both were middle-aged people who drank and smoked heavily and had poor diets.

Tetanus vaccination makes the body unsusceptible to the disease by inducing production of neutralising antibody (or antitoxin) to the tetanus toxin; this is the result of introducing weakened toxin into the body (the vaccine contains no attenuated bacilli). Therefore, it seems ludicrous to suppose sub-clinical (non-disease manifesting) contact with the bacilli such as we all must be experiencing regularly can’t do the same. Indeed, the comprehensive and authoritative Vaccines edited by S.A. Plotkin and W.A. Orenstein alludes to this: Studies in the developing world and some developed nations … have shown substantial proportions of some reportedly unimmunized populations … [to have] detectable levels of antitoxin. Specifically, up to 80 per cent of people in India and up to 95 per cent of people in a group of Ethiopian refugees had levels of antitoxin [considered protective]. However, these pro-vaccine establishment authors dismissed the findings by concluding, Even if natural immunity occurs in some unimmunized populations, it has no substantial importance in the control of tetanus.

In the case of tetanus, while better general health as a result of social change has to be a factor in the declining mortality rate, the most important reason was that wound care techniques and sterilization procedures greatly advanced in this period. It meant fewer women contracted tetanus after giving birth, less people contracted it from surgery and far fewer babies contracted it when the umbilical cord was cut. According to Plotkin and Orenstein, in the United States there were 90 per cent less tetanus deaths occurring in babies in 1930 than in 1900. Today, the World Heath Organization estimates that 400,000 babies in the Third World die each year of tetanus because of the use of unsterile cutting instruments and poor neonatal care while the umbilical stump heals. (Ref: Tetanus Vaccination by Jason Sanders  Issue, 97)

HIB Vaccines

Package Inserts

ActHib and OmniHib are conjugated with tetanus toxoid.

Hib Titer is conjugated with mutant diphtheria protein.

PedvaxHib and Comvax are conjugated with meningococcal group B outer membrane protein.

 

 Efficacy? The information varies based on the brand of vaccine. Table 2 at the end of this page http://www.cdc.gov/mmwr/preview/mmwr…m#00001680.htm tells how effective each dose number is.

Efficacy:

Results of efficacy trials among infants are available for the three conjugate vaccines. The first efficacy trial of an Hib conjugate vaccine among infants was completed in Finland using the PRP-D vaccine. In a systematic, unblinded trial involving 60,000 infants (30,000 of whom received the vaccine at 3, 4, and 6 months of age), the point estimate of efficacy was 87% (95% CI = 50%-96%) (10). In a randomized, double-blind, placebo-controlled study of 2,102 Alaskan Natives, however, the point estimate of efficacy was 35% (95% CI = (-57%)-73%) (11). Immunogenicity of the vaccine was limited in both trials. In the Finnish trial, less than 40% of infants had attained an antibody level of greater than 1 ug/mL 1 month after receiving the third of three doses (geometric mean titer (GMT) = 0.42 ug/mL). In Alaska, infants with a similar vaccination schedule had lower mean titers (GMT = 0.2 ug/mL) 3 months after receiving the third dose. A subsequent immunogenicity study documented antibody responses that were similar to those in the Alaskan and Finnish efficacy trials.

ActHib (Sanofi): ActHib was tested for safety by giving one group ActHib w/ DTP and the control group was given Hepatitis B w/ DTP. Here is an excerpt from the product insert:

 In a randomized, double-blind US clinical trial, ActHIB® was given concomitantly with DTP to more than 5,000 infants and Hepatitis B vaccine was given with DTP to a similar number.
In this large study, deaths due to sudden infant death syndrome (SIDS) and other causes were observed but were not different in the two groups.
In the first 48 hours following immunization, two definite and three possible seizures were observed after ActHIB® and DTP in comparison with none after Hepatitis B vaccine and DTP. This rate of seizures following ActHIB® and DTP was not greater than previously reported in infants receiving DTP alone. (Refer to product insert for AvP DTP.) Other adverse reactions reported with administration of other Haemophilus b conjugate vaccines include urticaria, seizures, hives, renal failure and Guillain-Barré syndrome (GBS). A cause and effect relationship among any of these events and the vaccination has not been established.

Children are at more risk of getting Hib disease right after vaccination.  

Studies from Science News warn of increased susceptability to the disease during the first 7 days after vaccination. The AAP has warned doctors to look for signs of the disease following vaccination (AAP policy statement.) Several studies have found that that Hib vaccinated children are up to 6 times more likely than non Hib vaccinated children to contract Hib during the first week following vaccination. (Pediatric Infectious Disease Journal and JAMA). 
 
In one study of children who got Hib at least 3 weeks after their vaccination, 70% developed meningitis. Additional research shows that antibody levels DECLINE rather than increase immediately following Hib vaccination, even with the newer conjugated vaccines. (Journal of Pediatrics, Pediatrics, and Pediatric Infectious Disease Journal.) 
 

Who are the highest risks?

 Children from lower socioeconomic families are at highest risk for getting Hib disease. (Physicians Desk Reference, 53rd edition, 1999 pg 3072)

Thirty-two percent of children aged 6–59 months with confirmed type b disease had received three or more doses of HIB vaccine, including 22 who had received a booster dose 14 or more days before onset of their illness. The cause of Hib vaccine failure in these children is not known.

Vaccine Linked with Diabetes:

 The British Medical Journal warns about the dangers of childhood vaccines. Investigators pooled data on roughly 116,000 Finnish children who received Heamophisis Influenza type b vaccine at either 3 or 24 months of age. These children were compared with 128,5000 children who did not receive the vaccine.
Subjects were reevaluated at age 10. The study’s author found that “immunizations starting after the age of 2 months is associated with an increased risk of diabetes. Our analysis is further associated with a similar rise in diabetis after immunization with H influenzae type b vaccine in the US and UK. Furthermore, the increased risk of of diabetes in the vaccinated group exceeds the expected decreased risk of complication of H influenzae meningitis.

Research into immunisation has been based on the theory that the benefits of immunisation far outweigh the risks from delayed adverse events and so long term safety studies do not need to be performed. When looking at diabetes only one potential chronic adverse event we found that the rise in the prevalence of diabetes may more than offset the expected decline in long term complications of H influenzae meningitis. Thus diabetes induced by vaccine should not be considered a rare potential adverse event. The incidence of many other chronic immunological diseases, including asthma, allergies, and immune mediated cancers, has risen rapidly and may also be linked to immunisation. Classen JB, Claussen DC. Public should be told that vaccines may have long term adverse effects. (Brit Med Journal 1999 (Jan 16);   318 (7177):193 full text)

 

 

 

The Hib vaccine can cause adverse reactions such as convulsions, allergic reactions such as anaphylaxis, vomiting, and serum sickness-like reactions. The FDA did not recognize these reactions when licensure was granted. Incidence of Hib type meningitis peaks between 6-11 months.
Daum RS, Sood SK, Osterholm, MT et. al.   Decline in serum antibody to the capsule of Haemophilus influenzae type b in the immediate postimmunization period   J Pediatr. 1989 (May);   114 (5):   742-747
Milstien JB, Gross TP, Kuritsky JN  
Adverse reactions reported following receipt of Haemophilus influenzae type b vaccine: an analysis after 1 year of marketing   Pediatrics 1987 (Aug);   80 (2):   270-274.

The “Finnish” study, upon which license was granted, showed the vaccine was  ineffective for infants 3-17 months of age.
Peltola H, Kayhty H, Sivonen A, Makela H   Haemophilus influenzae type b capsular polysaccharide vaccine in children: a double-blind field study of 100,000 vaccinees 3 months to 5 years of age in Finland.   Pediatrics 1977 (Nov);   60 (5):   730-737.
Shinefield HR, Hiatt RA, Fireman BH   Efficacy of Haemophilus influenzae type b capsular polysaccharide vaccine.   Pediatr Infect Dis J. 1988 (Mar);   7 (3):   149-156
Shapiro ED, Murphy TV, Wald ER, Brady CA   The protective efficacy of Haemophilus b polysaccharide vaccine.   JAMA. 1988 (Sep 9);   260 (10):   1419-1422
Harrison LH, Broome CV, Hightower AW, Hoppe CC, Makintubee S, Sitze SLA day care-based study of the efficacy of Haemophilus b polysaccharide vaccine.   JAMA 1988 (Sep 9);   260 (10):   1413-1418

Other studies showed the vaccine has no efficacy at all:
Ward JI, Broome CV, Harrison LH, Shinefield H, Black S   Haemophilus influenzae type b vaccines: lessons for the future   Pediatrics 1988 (Jun);   81 (6):   886-893.
Osterholm MT, Rambeck JH, White KE, Jacobs JL, Pierson LM, Neaton JD, Hedberg   Lack of efficacy of Haemophilus b polysaccharide vaccine in Minnesota   JAMA 1988 (Sep 9);   260 (10):   1423-1428.
Ward J, Brenneman G, Letson GW, Heyward WL   Limited efficacy of a Haemophilus influenzae type b conjugate vaccine in Alaska Native infants. The Alaska H. influenzae Vaccine Study Group   N Engl J Med 1990 (Nov 15);   323 (20):   1393-1401

 

 

 

The C.D.C. stated “Efficacy of the conjugate vaccine (currently being used) has not been determined in field trials. MMWR 1988, Vol. 37, RR-37, pp. 13-16.

Your baby will actually become more susceptible to meningitis for up to 3 weeks following vaccination.  Daum RS, Sood SK, Osterholm, MT et. al.   Decline in serum antibody to the capsule of Haemophilus influenzae type b in the immediate postimmunization period.   J Pediatr. 1989 (May);   114 (5):   742-747.
Ward J, Brenneman G, Letson GW, Heyward WL   Limited efficacy of a Haemophilus influenzae type b conjugate vaccine in Alaska Native infants. The Alaska H. influenzae Vaccine Study Group.   N Engl J Med 1990 (Nov 15);   323 (20):   1393-1401
Sood SK, Schreiber JR, Siber GR, Daum RS.   Postvaccination susceptibility to invasive Haemophilus influenzae type b disease in infant rats.   J Pediatr 1988 (Nov);   113 (5):   814-819.
Hiner EE, Frasch CE   Spectrum of disease due to Haemophilus influenzae type b occurring in vaccinated children.   J Infect Dis 1988 (Aug);   158 (2):   343-348.
Granoff DM, Shackelford PG, Suarez BK, Nahm MH et. al. Hemophilus influenzae type B disease in children vaccinated with type B polysaccharide vaccine. N Engl J Med 1986 Dec 18;315(25):1584-1590. Ward J   Newer Haemophilus influenzae type b vaccines and passive prophylaxis.   Pediatr Infect Dis J. 1987 (Aug);   6 (8):   799-803.
 The risk of contracting meningitis one week after vaccination is 6.4-1.8 times greater than unvaccinated children.
Sood SK, Schreiber JR, Siber GR, Daum RS   Postvaccination susceptibility to invasive Haemophilus influenzae type b disease in infant rats   J Pediatr 1988 (Nov);   113 (5):   814-819.

41% of cases of Hib occurred in vaccinated individuals. The vaccine’s protective efficacy is about negative 58%.  You are more likely to get Hib if you are vaccinated.
Osterholm MT, Rambeck JH, White KE, Jacobs JL, Pierson LM, Neaton JD, Hedberg   Lack of efficacy of Haemophilus b polysaccharide vaccine in Minnesota.   JAMA 1988 (Sep 9);   260 (10): 1423-1428.

The widespread use of the Hemophilus influenza vaccine in 1986 was followed by a 62% rise (16 cases/100,000 children to 29.2 cases/100,000) in the incidence of diabetes in the 0-4 age group between the years 1980-1982 and 1990-1992.
Tuomilehto J, Virtala E, Karvonen M, Lounamaa R, Pikaniemi J et. al.   Increase in incidence of insulin-dependent diabetes mellitus among children in Finland   Int J Epidemiol 1995 (Oct);   24 (5):   984-992.

The incidence of IDDM also rose in the young children 2-3 year olds after the first dose of HiB was introduced.
Classen DC, Classen JB   The timing of pediatric immunization and the risk of insulin-dependent diabetes mellitus   Infectious Diseases in Clinical Practice 1997;   6:   449-454.
Drastic rises in the incidence of IDDM have been reported in the US and the UK after the introduction of the HiB vaccine.
 An epidemic of diabetes in the 0-4 age group occurred during the years 1985-1989 in Allegheny County at the time when the Hemophilus influenza vaccine was being incorporated into the immunization schedule. The annual incidence of IDDM in 0-4 year  olds living in Allegheny county rose 60% from the years 1980-1984 (10 cases/100,000) to 1985-1989 (16 cases/100,000). The incidence of diabetes in  0-4 year olds had been consistently below 10 cases/100,000 from 1965-1984.  The incidence of IDDM in this age group is expected to rise even higher since  the maximum effect of the HiB vaccine on IDDm is not seen until 4 years after  immunization.
 India appears to have a high rate of natural immunity:

 Studies from the early 1970’s might hold an explanation for this phenomenon. It is known that other bacteria have cross-reactive antigens to the Hib capsular polysaccharide. In an elegant experiment with burros, Bradshaw et al demonstrated the development of serologically specific precipitate antibodies to Hib after immunization of animals with Stephylococcus aureas and Bacillus subtillis. Strains of Staphylococci, Group D. Streptococci, Diphtheroids and Escherichia coli have been found with cross-reactive antigens to Hib. Robbins et al have demonstrated that infants show enhanced immune response to H influenzae capsular polysaccharide when they have concurrent cross reacting E. coli infection of the gut. Under these circumstances, a rapid and sustained rise in antibody to Hib was noted. E. Coli are ubiquitous in developing countries like India and their presence in the gut may have helped to stimulate antibody to Hib in the subjects reported….. There is thus a great potential for savings to be made in vaccination us in developing countries, if this finding is further substantiated. (Puliyel JM, Agarwal KS, Abass FA. Natural immunity to haemophilus b in infancy in Indian children. Vaccine 2001; 19: 4592-4594.)

 

 Hib and E Coli are not killers in undeveloped countries because the people can’t afford antibiotics. When you use antibiotics, the gut flora becomes unbalanced and causes E. Coli numbers to explode; making them very dangerous. Antibiotics kill E.Coli, and by doing so, can kill. The bacterial cell walls become endotoxin which cannot be processed by the liver and thus the person dies from antibiotic-induced endotoxic shock. Since 70% of the immune system resides in the gut, if you use antibiotics too much, not only do you create imbalances, you also create situations where you wouldn’t get good levels of diverse ‘good’ flora, so that they can make good levels of immunity to Hib.

Hepatitis B Vaccines

Hepatitis B Vaccines:

·         Engerix B

·         Recombivax HB

·         Twinrix (Hep A and B)

·         Pediarix (DTaP, IPV and Hep B)

·         Comvax (Hep B and HIB)

·         Nabi-HB = Immune Globulin

 ·         Bay Hep B = Immune Globulin (human)

 ·         HB-vax II

·         PTY LTD

 ·          Hexa (DTaP, Hep B, HIB, IPV)

Contains Thimerosal (mercury): Engerix B and Twinrix

Contains Aluminum: Pediarix, Recombivax, Comvax

Contains Fetal Cell lines: Twinrix (MRC-5)Hexa (MRC-5)

Energix B (Hep B) Glaxo:  

The CONTROL GROUP received plasma-derived vaccines. The vaccines administered to the CONTROL GROUP are not revealed.

Ten double-blind studies involving 2,252 subjects showed no significant difference in the frequency or severity of adverse experiences between ENGERIX-B and plasma-derived vaccines.
In 36 clinical studies, a total of 13,495 doses of ENGERIX-B were administered to 5,071 healthy adults and children who were initially seronegative for hepatitis B markers, and healthy neonates. All subjects were monitored for 4 days post-administration.

 

 
Recombivax HB (Hep B) Merck:

 

This vaccine was not evaluated for safety using a control group.

In three clinical studies, 434 doses of RECOMBIVAX HB, 5 mcg, were administered to 147 healthy infants and children (up to 10 years of age) who were monitored for 5 days after each dose.
In a study that compared the three-dose regimen (5 mcg) with the two-dose regimen (10 mcg) of RECOMBIVAX HB in adolescents, the overall frequency of adverse reactions was generally similar.
In a group of studies, 3258 doses of RECOMBIVAX HB, 10 mcg, were administered to 1252 healthy adults who were monitored for 5 days after each dose.

 

     

    • At no point was Hepatitis B evaluated at birth, to see what effect it would have on either liver enzymes, or immune system parameters.

    In 1982, the C.D.C., the F.D.A., and the manufacturer created a surveillance system to monitor spontaneous reports of adverse events occurring after inoculation with the new-plasma derived hepatitis B vaccine (Heptavax-B, Merck Sharp and Dohme, West Point, PA). In the three years between June 1, 1982 and May 31, 1985, an estimated 850,000 persons received the vaccine. During that period, a total of 41 reports were received for one of the following neurologic adverse events: convulsions (5 cases), Bell’s palsy (10 cases), Guillain-Barre syndrome (9 cases), lumbar radiculopathy (5 cases), brachial plexus neuropathy (3 cases), optic neuritis (5 cases), and transverse myelitis (4 cases).  Half of these occurred after the first of three required vaccine doses. In some analyses, Gullain-Barre syndrome was reported significantly more often that expected (p=<0.05). Shaw FE, Jr., Graham DJ, Guess HA, Milstien JB et. al.   Postmarketing surveillance for neurologic adverse events reported after hepatitis B vaccination. Experience of the first three years   Am J Epidemiol 1988 (Feb);   127 (2):   337-352

     When Evidence Based Medicine (EBM) Fuels Confusion: Multiple Sclerosis after Hepatitis B Vaccine as a Case in Point.M. Girard/Medical Veritas 4 (2007) 1436-1451.

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        One of the major side effects of the Hepatitis B vaccine in the kids ‘catch-up campaign’ is “bronchospasm” and kids who have asthma are nearly always guaranteed to have a serious asthma attack on the day of their shot.  

      RHEUMATIC DISORDERS DEVELOPED AFTER HEPATITIS B VACCINATION
      Aim
      : to obtain an overview of rheumatic disorders occurring after hepatitis B vaccination.

      Conclusion: hepatitis B vaccination might be followed by various rheumatic conditions, and might trigger the onset of underlying inflammatory and/or auto-immune rheumatic diseases. However, a causal relation between hepatitis B vaccination and the observed rheumatic manifestations cannot be easily established. Further epidemiological works are needed to establish whether hepatitis B vaccination is associated or not with an incidence of rheumatic disorders higher than normal.

      Other Studies:

      Several papers have been published linking immunization to lupus and other rheumatoid diseases. A study of lupus patients receiving polio vaccines showed 5% had a flare following immunization (Schattner et al., 1992). Several papers have reported patients with lupus developing deterioration in kidney function following immunization (Ristow et al., 1978); (Louie et al., 1978). Lupus has been reported to occur following immunization with the Hepatitis B (Tudela et al., 1992), and pneumococcal (Ries & Shemonsky, 1981) vaccines. Immunization with the influenza vaccine has been associated with a rise in anti-double stranded DNA antibodies, an marker for lupus (Huang et al., 1992). Rheumatoid arthritis has been observed to occur following immunization with Hepatitis B vaccine (Vautier & Carty, 1994). Rheumatoid factor, auto antibodies that bind other antibodies, have been reported to develop following vaccination (Aho et al., 1962); (Aho et al., 1967); (Palit et al., 1977); (Welch et al., 1982).

       The Genetic Centers of America, MedCon, Inc., Silver Spring, Maryland 20905, USA.

       OBJECTIVES: Adverse events and positive re-challenge of symptoms reported in the scientific literature and to the Vaccine Adverse Event Reporting System (VAERS) following hepatitis B vaccination (HBV) were examined.

       

       

       

      METHODS: The VAERS and PubMed (1966-2003) were searched for autoimmune conditions including arthritis, rheumatoid arthritis, myelitis, optic neuritis, multiple sclerosis (MS), Guillain Barre Syndrome (GBS), glomerulonephritis, pancytopenia/thrombocytopenia, fatigue, and chronic fatigue, and Systemic Lupus Erythematous (SLE) following HBV.  

       

      RESULTS: HBV was associated with a number of serious conditions and positive re-challenge or significant exacerbation of symptoms following immunization. There were 415 arthritis, 166 rheumatoid arthritis, 130 myelitis, 4 SLE, 100 optic neuritis, 101 GBS,
      29 glomerulonephritis, 283 pancytopenia/thrombocytopenia, and 183 MS events reported following HBV A total of 465 positive re-challenge adverse events were observed following adult
      HBV that occurred sooner and with more severity than initial adverse event reports. A case-report of arthritis occurring in identical twins was also identified.

      CONCLUSIONS: Evidence from biological plausibility, case-reports, case-series, epidemiological, and now for positive re-challenge and exacerbation of symptoms, and events in identical twins was presented. One would have to consider that there is causal relationship between HBV and serious autoimmune disorders among certain susceptible vaccine recipients in a defined temporal period following immunization. In immunizing adults, the patient, with the help of their physician, should make an informed consent decision as to whether to be immunized or not, weighing the small risks of the adverse effects of HBV with the risk of exposure to deadly hepatitis B virus. (NEUROLOGY 2004; 63:838-842 American Academy of Neurology,   Miguel A. Hernán, MD et al)

      • Recombinant hepatitis B vaccine and the risk of multiple sclerosis-A prospective study.
        Miguel A. Hernán, MD et al.

         

        • Conclusions: These findings are consistent with the hypothesis that immunization with the recombinant hepatitis B vaccine is associated with an increased risk of MS, and challenge the idea that the relation between hepatitis B vaccination and risk of MS is well understood.
         

         

         

      Celiacs less likely to gain immunity from Hep B:  

      A total of 23 subjects were reviewed. All had a clinical and pathological diagnosis of celiac disease. All subjects reported receiving the full series of hepatitis B vaccinations. Of the subjects, 19 had testing for hepatitis B vaccine response. Of these 19 subjects, 13 did not achieve long-term immunity as seen by the negative qualitative or quantitative anti-HBs antibody titer.

      Hepatitis B Study:

      Conclusions: Anti-HBs disappeared by 5 years of age in most children who were vaccinated with hepatitis B vaccine from birth. Although most children showed immunologic memory, one-third failed to demonstrate an anamnestic response to a booster dose. Additional long term studies of low risk infants are needed to determine duration of protection and the necessity for or timing of booster doses.

      HEPATITIS B VACCINE: The first hepatitis B virus vaccines developed in the 1970s were made using virus isolated from the blood of human chronic hepatitis B carriers. A plasma-derived hepatitis B vaccine was licensed by the U.S. in 1981 and used in high-risk populations in the 1980s until a genetically engineered, recombinant hepatitis B vaccine was developed. Today, hepatitis B recombinant vaccine used in the U.S. is derived from hepatitis B surface antigens produced in yeast cells. A portion of the hepatitis B virus gene is cloned into the yeast (a common baker’s yeast) and the vaccine is produced from cultures of this recombinant yeast strain. The vaccine is treated with formaldehyde and contains 95 percent hepatitis B virus surface antigen, 4 percent yeast protein, aluminum hydroxide and thimerosal added as a preservative.” (source: The Consumer’s Guide to Childhood Vaccines by Barbara Loe Fisher).