The Role of Male Circumcision in the Prevention of Human Papillomavirus and HIV Infection

Effect of Male Circumcision on the Prevalence of High-Risk Human Papillomavirus in Young Men: Results of a Randomized Controlled Trial Conducted in Orange Farm, South Africa (The Journal of Infectious Diseases 2009;199:14–19)

Background.  A causal association links high-risk human papillomavirus (HR-HPV) and cervical cancer, which is a major public health problem. The objective of the present study was to investigate the association between male circumcision (MC) and the prevalence of HR-HPV among young men.

Methods.  We used data from a MC trial conducted in Orange Farm, South Africa, among men aged 18–24 years. Urethral swab samples were collected during a period of 262 consecutive days from participants in the intervention (circumcised) and control (uncircumcised) groups who were reporting for a scheduled follow-up visit. Swab samples were analyzed using polymerase chain reaction. HR-HPV prevalence rate ratios (PRRs) were assessed using univariate and multivariate log Poisson regression.

Results.  In an intention-to-treat analysis, the prevalences of HR-HPV among the intervention and control groups were 14.8% (94/637) and 22.3% (140/627), respectively, with a PRR of 0.66 (0.51–0.86) ( ). Controlling for propensity score and confounders (ethnic group, age, education, sexual behavior [including condom use], marital status, and human immunodeficiency virus status) had no effect on the results.

Conclusions.  This is the first randomized controlled trial to show a reduction in the prevalence of urethral HR-HPV infection after MC. This finding explains why women with circumcised partners are at a lower risk of cervical cancer than other women.

Trial registration.  ClinicalTrials.gov identifier: NCT00122525.

Full Study

Commentary: The Role of Male Circumcision in the Prevention of Human Papillomavirus and HIV Infection (The Journal of Infectious Diseases 2009;199:1–3)

 

Medical ‘Conscience Rule’ Is Issued

Medical ‘Conscience Rule’ Is Issued

The Bush administration, as expected, announced new protections on Thursday for health care providers who oppose abortion and other medical procedures on religious or moral grounds.

“Doctors and other health care providers should not be forced to choose between good professional standing and violating their conscience,” Michael O. Leavitt, the secretary of Health and Human Services, said in a statement on his department’s Web site.

The rule prohibits recipients of federal money from discriminating against doctors, nurses and health care aides who refuse to take part in procedures because of their convictions, and it bars hospitals, clinics, doctors’ office and pharmacies from forcing their employees to assist in programs and activities financed by the department.

“This rule protects the right of medical providers to care for their patients in accord with their conscience,” Mr. Leavitt said.

The Bush administration had signaled its intention to issue the measures, which are part of a flurry of regulations it is announcing before President-elect Barack Obama takes office. The new president will be able to undo the regulations, and is virtually certain to, given his previous comments on the issue. But undoing them will be a time-consuming process.

The measures announced on Thursday, sometimes described collectively as the “conscience rule,” were issued just in time to take effect before the start of the new administration. They will go into effect 30 days after their publication in the Federal Register on Friday. Recipients of funds from the Department of Health and Human Services are required to certify their compliance with the rule by October 2009.

“If, despite the department’s efforts, compliance is not achieved, H.H.S. officials will consider all legal options, including termination of funding and the return of funds paid out in violation of the non-discrimination provisions,” Mr. Leavitt said.

Opponents of abortion, including the United States Conference of Catholic Bishops and the Catholic Health Association, which represents Catholic hospitals, support the new regulations and say they are needed to protect health-care providers from being forced to perform abortions and sterilizations.

They are opposed by the National Association of Chain Drug Stores, the American Hospital Association and the American Medical Association, among others. Opponents contend that the regulations are a threat to a woman’s right to choose to have an abortion, and that they are not needed in any event because the Civil Rights Act of 1964 already prohibits employment discrimination based on religion.

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Then parents need to have the same rights to have a conscience law in every state that allows them to refuse vaccines as it is a medical procedure :)

The Lies Parents are Told…

Over the years I have lost count on the number of times I have heard parents being told untruths or given misinformation about vaccine exemptions, the number of vaccine doses their child needs for school or daycare attendance, which vaccines are mandated by their state, that a daycare center won’t allow their unvaccinated child to attend, or that their child will be kicked out of daycare or school for vaccine delinquency. Some parents have also been told by their doctors or health departments they need every vaccine and every dose on the CDC schedule to attend daycare or school. Others have been told they can’t get individual vaccines because they don’t exist, such as MMR.

 

 

Let’s set the record straight:

 

1. Every state has exemptions whether it is medical, religious, or philosophical (personal). Some states only allow medical, some allow medical and religious, while others allow all three.

 

2.  Individual vaccines are produced and can be given. A doctor or health department may simply choose not to give them, stock them, or order them for you.

 

 

3.  States are not uniform in the vaccines they mandate for daycare attendance and school entry and the number of doses a child is required to have. For instance, some states may require five doses of DTaP for school attendance, while some states may require only four doses. Doctors and health departments, however, will simply follow the CDC recommended schedule even if it is not mandated for school or daycare entry.

 

4. Children can not be kicked out of school immediately for not having had all the vaccines required by their individual state mandate. There are grace periods which allows time for either an exemption to be submitted, or for vaccines to be given and caught up.

 

5. Daycare centers have state regulations and written within those regulations are state immunization laws which tell you what vaccines and the number of doses that are required for attendance, and solely pertain to children under the age of five. Daycare vaccine exemptions follow the same state exemption laws outlined for school-aged children. A daycare center can not simply tell you they don’t accept a child without first reviewing your submitted exemption or delay/selective schedule.

 

A good source for information and the most up-to-date vaccine exemption issues and laws is Vaccine Liberation. I highly advise however, that you contact someone in your state for additional information and for one-on-one guidance if you are exempting vaccines in some states such as N.J. or N.Y. for instance. Nearly every state has a coalition or group that can help you further.

 

In future blogs, Exploring Vaccines will list all the individual state vaccine mandates for daycare and school attendance as a ‘quick easy-viewing reference’, what exemptions are available, state coalitions, etc.

 

 

Some New York Times Reporters are Just Ignorant

ReviewerBy J.B. Handley

There’s a reporter named Gardiner Harris who writes for the New York Times. I’ve probably talked to a hundred or so reporters in my time and he is unquestionably the biggest jackass I have ever encountered. Aside from being snide, cynical, wildly biased, dismissive, and arrogant, there’s also this ditty, in a private email to me that explains it all:

“but scaring parents away from life-saving medicines is no way to improve this terrible situation. i have met parents who lost their children to vaccine-preventable diseases, and they are haunted. if you had your way, there would be far more of these haunted souls. i hope to prevent that from happening.” – Gardiner Harris

So, he’s also a vaccine zealot.

Continued

State Tobacco Cash Funneled Into Vaccines

State Tobacco Cash Funneled Into Vaccines, Biotech Drug Delivery, Cardiac Arrest, and Mental Health Research

Washington’s Life Sciences Discovery Fund just made a bunch of biomedical researchers either very happy, or highly disappointed. The 10-year, $350 million initiative, which takes money from the state tobacco settlement, chose to pump almost $19 million into four grant proposals that explore development of new vaccines, improved ways to treat cardiac arrest, rural mental health, and how to better deliver biotech drugs into cells.

This was a big round of grants for the fund. Before today, the quasi-state agency had divvied out 17 grants to researchers worth a combined $32 million. I got an update on the strategy of the program, and it’s progress thus far, in September during an interview with executive director Lee Huntsman. A total of 29 grant applications were sent in, and 10 of them were closely scrutinized through interviews by reviewers with the American Association for the Advancement of Science, and the board’s trustees. “All of them were of high scientific and technical merit,” said Lura Powell, chair of the board of trustees.

The aim of these grants, Powell said on today’s conference call, is to advance health care for Washington residents, strengthen the local economy, and promote the region’s competitiveness as a global biotech hub.

With that in mind, here’s a rundown of the newest grant recipients announced today. All of them won by a unanimous votes.

Continued

Alzheimer’s and Autism

Alzheimer’s and Autism

One of the key issues put forward by the attorneys for the families in the Omnibus Autism Proceeding was whether the measles virus could survive for years in children with autism without being eradicated by the body.

Recent research from the University of Manchester points to the continued persistence of viruses in the body where they may be responsible for the amyloid plaques which are the hallmark of Alzheimer’s disease. (“Herpes Simplex Virus Type 1 DNA is Located within Alzheimer’s Disease Amyloid Plaques”, The Journal of Pathology, Volume 217, issue 1, pages 131-138)  The research was also highlighted in an article in Science Daily. (“Cold Sore Virus Linked to Alzheimer’s Disease, December 7, 2008)

Continued

Encephalitis and Encephalopathy (part 3)

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Since the 1950’s, an increase in chronic disease was underway and has continued to rise rapidly ever since. We have essentially replaced self-limiting infectious diseases with chronic diseases that last a life time. Asthma, allergies, diabetes, seizure disorders, epilepsy, auto-immune diseases, sleep disorders, ADD/ADHD, dyslexia, behavioral syndromes, obesity, alcohol abuse, drug abuse, mental retardation, eating disorders, and sexual disorders are some of the chronic diseases children and adults suffer from today. Do parents or the medical community really think that trading a self-limiting disease, such as the chickenpox, for long life chronic disease is better?

What has history shown?

1. It is not surprising that the rise started in the 1950s and 1960s. Mass vaccination started after World War II, in the mid-1940s. Discussion of why “Johnny can’t readstarted in the mid-1950s, when this vaccinated generation started going to school, as did the rise in autoimmune diseases. But when this generation came to the age of 18 (1963) and entered the adult statistics, IQs started to decline, the crime rate started to rise, etc. etc.

2. The role of genetics: not everyone suffers equally from a vaccination. This tendency does run in families, however, and would seem to have a genetic component.

3. The black population and urban violence. Black children suffer from a variety of disabilities which makes them much more vulnerable to the effects of vaccination: more than 50% are out-of-wedlock births, meaning no father, an uneducated mother, no funds, no pregnancy care etc. Also more than 50% (75% ?) are premature and low birthweight (under 4-5 pounds). This also renders them highly vulnerable to the effects of vaccination.

Short-term vs. Long Term Chronic Disease

Short term, or also known as acute reactions, is also known as encephalopathy. They are usually seen as physical symptoms. These could be seen as swelling at the injection site, high fever, rash, high pitched crying or screaming (cry-encephalitis) that continues for days, breathing difficulties, fainting, sleepiness, convulsion or a seizure, or a “sudden death.” The short-term reactions can be recovered from. But all too often, the long-term effects begin to be seen. Seizures or convulsions become chronic epilepsy. Vision or hearing problems begin, or your baby or toddler suddenly becomes mute. Cerebral palsy or Autism is now questioned or evaluated.

 

According to Harris L. Coulter, Ph.D:

 

…children and adults who have been damaged by vaccination but not severely enough to be institutionalized. Their condition I have called the “post- encephalitic syndrome.”

The modern literature of psychiatry describes this condition as “conduct disorder” in young children or “sociopathic personality” in adults. These are subcategories of a larger group called “developmental disabilities,” which includes autism, dyslexia, hyperactivity, attention-span difficulties, and several dozen other conditions. The most recent edition of the Diagnostic and Statistical Manual published by the American Psychiatric Association devotes 80 pages to these disorders.

Encephalitis (whether from vaccination or from some other cause) can range from severe to moderate, even subclinical. It is also possible to have encephalitis in which the acute symptoms are extremely mild but which still does much long-term damage.

They rarely show remorse for what they have done but dissociate themselves from their acts. This may be because they sense that the impulse is outside their ability to control it — like a facial tic or a sneeze.

The “less serious” long-term sequelae resemble the more severe cases but are milder.

They have lowered resistance to infection — due, presumably, to defective operation of the immune system.

Instead of having epilepsy or seizures, the children suffer from what are called “staring spells” or “absence seizures.”

Instead of being totally deaf, they have mild loss of hearing. Or they have chronic earaches — otitis media. This is called in the United States “glue ear,” and it is a kind of buildup of water in the ear, often requiring the installation of little tubes for drainage.

Instead of being mentally retarded to the point of incapacity to function in society, they suffer loss of IQ: many function at the 80 or 90 IQ level — just above subnormality.

They are given to outbursts of rage. When combined with their tendency to impulsive behavior, this leads to many acts of impulsive violence. These individuals are frequently involved in crime, or the violence may be self- directed (suicide).

Instead of paralysis or cerebral palsy, they may lose a degree of muscular control — “atony” — especially of the hands. The parents will say that the baby doesn’t use his hands for crawling, or that he picks up objects with his feet instead of his hands.

The child will have asthma or other breathing difficulties. The incidence of asthma has been steadily rising in the United States for the past several decades — especially asthma in very small children. Children now are dying of asthma, whereas in the past doctors always used to say that “no child ever dies of asthma.”

They manifest all the cranial nerve palsies, but in a less severe form.

Another long-term effect of this vaccine is tendency to allergies, especially allergy to milk. Needless to say, a large proportion of the population in all of the industrialized countries of the world today suffer from allergies. We found that newborn infants with colic — meaning an allergy to milk– tend to react more strongly to the vaccine. Undoubtedly colic should be considered a counterindication to vaccination.

Instead of being blind, they have astigmatisms and nystagmus (involuntary and jerky repetitive movements of the eyeballs). They can be cross-eyed. They may have trouble moving their eyes from side to side. Or they are dyslexic, cannot read letters, cannot spell, cannot understand numbers, and the like. A peculiar feature is that they sometimes have obsessions about people’s eyes, are afraid to look others in the eyes, etc.

They are fascinated by fire and attracted to burning buildings and the like.

…This particular “glue ear” type of otitis was not known in American medical practice before the late 1940’s or early 1950’s — in other words, the time when the pertussis vaccine was being introduced.

Instead of being completely dumb, they may have a peculiarly harsh or dull or inexpressive voice. Often they stutter and have other speech impediments.

Migraine headaches are also very common in this population.

Another long-term effect is disturbance of sleep rhythm; the child turns night into day and day into night.

 They have sleep and appetite disturbances — anorexia and bulimia. In the latter case, they will often put on weight.

So one finds the same kinds of physical disabilities as in the more profoundly affected children, but everything is somewhat milder. “Mild” here is a relative term. After all, hyperactivity, dyslexia, and short attention span are very serious social problems — leading, in fact, to the collapse of the American educational system today.

They are often hyperactive. They have an extremely short attention span. Their behavior is dominated by impulses.

Other serious disorders are: seizures and epilepsy, blindness or loss of speech, paralysis or palsy of one or several limbs, and mental retardation. These are all possible effects of the vaccine.

…the mental, emotional, and moral dimensions of vaccine damage.

These children have a typical personality profile. They are alienated and paranoid. They have severe ego weakness — low self-esteem. They are anxious and depressed. They cannot tolerate frustration. They have an overwhelming need for control and panic when losing control of a situation. They are precociously sexual with a high level of homosexuality and bisexuality, and have tendencies to obsessive behavior, including alcoholism and drug abuse.

 

All of these sound familiar don’t they? What then happens to these children when they become adults?

 Harris L. Coulter, Ph.D:

…As this same generation went on into early adulthood, it created and has maintained the present historically high incidence of violent crime. Violent crime (murder, rape, aggravated assault) started to rise in the early 1960s and is still on the rise today.

At least two routes connect the post-encephalitic adolescent with alcoholism and/or drug abuse. (1) These individuals, as already noted, suffer from anxiety, depression, and low self-esteem and are thus naturally inclined to indulge in these various forms of escape. (2) There are numerous programs in U.S. schools today calling for the drug treatment of children with such conditions as hyperactivity, attention-span difficulties, and learning disabilities; approximately a million such children throughout our school systems are regularly being prescribed amphetamines and amphetamine-like drugs such as methylphenidate or pemoline for these conditions. These are addictive drugs, and it is not surprising that these children should grow up to become drug addicts.

…A large body of research has been done on the neurologic status of persons involved in violent crime. They are seen to have a very high incidence of typical post-encephalitic conditions: low IQ, hyperactivity, allergies, mental retardation, and seizure disorders.

…There is a clear relationship between the post-encephalitic syndrome and premature, exaggerated sexuality. Today we are confronted with a rise in sexually related crimes, including acts of sexual violence committed by children — as young as six or seven years of age. Accounts of these children make it clear that they suffer from other symptoms along the lines we have discussed: mental retardation, hyperactivity, learning disabilities, tendency to commit arson, and, finally, lack of remorse for their acts.

Drugs and alcohol potentiate the inherent weaknesses of the post- encephalitic personality, releasing the few inhibitions which these individuals already possess…

It would not be an exaggeration to state that the three major social problems facing the United States today: the collapse of the educational system, drug abuse, and the epidemic of violent crime are all rooted, to a considerable extent, in the prevalence of the post-encephalitic syndrome in American society. This is true for many European countries also, although to a lesser extent.

 

All of these above disorders of post-encephalitic syndrome were rare before the mandated vaccine programs began and history has shown this.

 

Harris L. Coulter, Ph.D:

 

“In examining the enormous literature on infectious encephalitis, I realized very quickly that the long-term effects of encephalitis is totally congruent with what we see today in the DSM3 of the American Psychological Association as “Disorders usually evident in infancy or childhood” (developmental disabilities).  That includes autism, hyperactivity, dyslexia, attention span difficulties and several dozen other conditions.”

“But no biological phenomenon is either all or nothing.  Vaccination cannot be considered to either leave a child perfectly normal or have a very severe impact on a child.  There’s got to be a range of effects-how about the children in the middle?  How about those who are slightly affected by the vaccine?  Anybody who knows anything about the biology of medicine knows that this has to be because it would be impossible to stress a large group of people, like two million babies a year in the United States and not have the reactions go along a  whole range of effects….Some of the side effects or long term affects make themselves felt not the next week or two weeks later but five or ten years later when the parent realizes that their child is not acting or behaving like other children act and tries to figure out what the reason for that is….”

 

“This is, at first glance, a startling omission,” says Coulter.  When the neurologic (as opposed to psychological) nature of autism was finally revealed, “mental health professionals should have immediately appreciated the tie with encephalitis.  Furthermore, it had long been known that a variety of encephalitis was caused by vaccination.  But this is precisely why physicians shied away from the topic!  Since no one wanted to impugn the [vaccination] programs, encephalitis was never discussed openly and fully.

“The Vaccine Compensation Bill of 1986 provided for the establishment of a committee under the The National Academy of Sciences Institute of Medicine to review data on vaccine damage.  This committee has published two books – one in 1989 and one in 1993 on the damage of various vaccines and they have stated in the first of these books that the evidence supports the existence of a causal relationship between the DPT vaccine and encephalitis.  That has changed the whole terms of the debate because now you can talk of vaccine damage in terms of encephalitis-that is a much more solid scientific basis.

 

 Autismfacts.com

Many of the studies found a substantial proportion of children had a physical condition such as maternal rubella, prenatal trauma, encephalitis, epilepsy or tuberous sclerosis which were all potential explanations for the autism disorders. Most of today’s children with autism were born healthy and suffered no injury or illness that could be a possible explanation.

  Different diagnostic criteria were used in the studies. Those used were:

 Kanner’s Criteria:

1) A profound lack of affective contact
2) Repetitive, ritualistic behavior which must be of an elaborate kind

 

   *Kanner gave some examples of behavior and did not include age of onset as essential. Kanner’s Criteria for diagnosis is the most restrictive criteria used. It mainly focuses on the most severe forms of autism and does not allow for milder cases of autism found in Asperger’s Syndrome and PDDNOS (Pervasive Developmental Disorder Not Otherwise Specified). Some studies, however, that used Kanner’s criteria allowed for “atypical” autism cases to be counted, or those that did not fully fit the picture of Kanner’s criteria.

 

Rutter’s Criteria:

1) Impaired social development which has a number of special characteristics out of keeping with the child’s intellectual level
2) Delayed and deviant language development that also has certain defined features and is out of keeping with the child’s intellectual level
3) “Insistence on sameness” as shown by stereotyped play patterns, abnormal preoccupations or resistance to change
4) Onset before 30 months

 

   *Rutter gave many examples of behavior. Rutter’s Criteria for diagnosis is broader than Kanner’s and allows for more children to be diagnosed, but whom still fit more typical or classic autism patterns. Milder cases of the Autism Spectrum would still not fit the criteria.

 

DSM-III Criteria

1) Lack of responsiveness to others
2) Language absence or abnormalities
3) Resistance to change or attachment to objects
4) The absence of schizophrenic features
5) Onset before 30 months

 

   *DSM-III also had categories for childhood onset (after 30 months and before 12 years) and for atypical pervasive developmental disorder (PDD).

 

   *The DSM-III criteria for diagnosis was far broader than any previous criteria. It recognized that autism could occur in any level of severity and now included the symptoms of Asperger’s Syndrome, although it did not directly name the disorder. Passive acceptance of social approaches and one-sided approaches were now included as social impairment. The criteria allowed for more milder cases of autism to be counted.

 

DSM-III Revised criteria:

1) Impairment in reciprocal social interaction (at least 2 from 5 items, comprising of specified clinical examples)
2) Impairment in verbal and nonverbal communication (at least 1 of 6 items)
3. Markedly restricted repertoire of activities and interests (at least 1 of 5 items)
4. A grand total of at least 8 from among the 16 items listed.

 

   *This shift included children with the most subtle symptoms. The DSM-III Revised criteria for diagnosis was the broadest criteria to exist to date. The DSM-III had been revised because many doctors believed the DSM-III was too restrictive and did not allow for children who were clearly autistic to be diagnosed because of varying symptoms and histories. But, many doctors felt that the DSM-III Revised edition was too broad and would include children who did not have autism to fit the criteria. The various subtypes of the spectrum were put into a single category of PDDNOS.

 

Criteria used in one Japanese study:

1) Disturbed interpersonal relationships (defined by a list of clinical examples comprising of 9 items)
2) Absence or deviance in speech and language development (8 items).
3) Insistence on the preservation of sameness or resistance to change (6 items).
4. Abnormal responses to sensory stimuli or motility disturbance (10 items).

 

   *The criteria used in this one study is a mix of new and old criteria used in other studies. Numbers 2 and 3 are similar to criteria used in other studies, but the broadness of number 1 is different than others and number 4 is the only criteria that included sensory and motor disturbances.

 

Today’s criteria, DSM-IV:

   DSM-IV, which is used today, continued the broader conception of the DSM-III, yet attempted to rein back on its DSM-III Revised edition by combining the two, but also restricting the criteria so that it would not catch those who did not have an autistic disorder. It achieved this by improving its specificity as well as separating the subtypes of autism.

THE STUDIES

 

   In 1966, Victor Lotter published the first study of the prevalence of autism in Middlesex, an English county in Britain.

 

   He searched for children with typical autism between the ages of 8 and 10 who were born between 1953 and 1955 as described by Kanner. He used a screening schedule for teachers in all schools and case notes reviewed for children in special schools as his method. He found 35 children out of 77,800 with a rate of 4.5 children per 10,000 (1 per 2222). Of those who fit typical autism, 2 per 10,000 (1 per 5,000) were found and a rate of 2.5 per 10,000 (1 per 4,000) were found with atypical autism.

 

   Classification of typical autism or atypical autism depended on how closely the clinical picture fitted the clinical criteria. Almost all had some degree of mental retardation and some had other conditions suggesting brain dysfunction. He also found that girls diagnosed as autistic tend to be more severely mentally retarded than the autistic boys. A substantial proportion of children had a physical condition such as maternal rubella, prenatal trauma, encephalitis, epilepsy or tuberous sclerosis. The rates given were below the mean rate tabulated.

 Continued…

 

Classic and everyday children’s illnesses in practice

Post-vaccinal encephalitis (PVE)

1. Post-vaccinal encephalitis (PVE)

The Prague pathologist Prof. Lucksch coined this phrase in 1924 and described, in a number of scientific studies, brain damage following inoculations where the children were all over the age of three.  Austrian professors Kaiser and Zappert adopted Prof. Lucksch’s designation in an investigation carried out on 240 children, 237 of whom were older than three at the time of vaccination.

2. (Bland) post-vaccinal encephalopathy

The Dutch pathologist de Vries demonstrated that, up to the age of three, a child cannot react to damage caused by inoculation with an inflammatory defensive reaction of the brain! A baby’s brain merely reacts to post-vaccinal damage with cerebral oedema and unformed blood constituents escaping from the blood vessels as an expression of disruption of the blood-brain-barrier.

Unlike encephalopathy, encephalitis is an easily identifiable clinical picture. Consequently post-vaccinal damage was identified in Austria, yet not in Germany and it is becoming apparent why there were seemingly fewer post-vaccinal reactions in Germany than in Austria.

Lucksch, Kaiser and Zappert were unable to make a distinction between the above terms as, in Austria and northern Bohemia, inoculations were carried out at a much later stage than was the case in Germany.

3. Post-vaccinal reactions / post-vaccinal complications / post-vaccinal damage

As defined by the German Federal Epidemics Law, post-vaccinal damage is health damage which extends beyond the usual extent of a post-vaccinal reaction and is generally permanent. This damage must become apparent within a certain period after inoculation and is known as “standardized incubation period.” An incubation period of between three days and three weeks is given for PVE and post-vaccinal encephalopathy with acute symptoms of disorientation and even unconsciousness, fever extending beyond the tenth day after inoculation, convulsive attacks either generalised or accentuated on one side, limb pal[TEXT INCOMPLETE IN ORIGINAL SOURCE.] occasionally isolated cranial nerve p[TEXT INCOMPLETE IN ORIGINAL SOURCE.] rare cases meningism.

In addition, however, developments with fewer symptoms are described, known as bland post-vaccinal encephalopathy. The symptoms here are abnormal behaviour such as drowsiness, loss of interest, refusal to eat, vomiting, arrested development with loss of previously acquired faculties, progressive cerebral organic disorders.

Sticker (1908) and Petov (1930) were able to prove beyond doubt firstly, that hayfever occurred far more frequently among the privileged classes of town dwellers than in the rural population where pollen was more prevalent. Secondly, they described initial manifestation following revaccination beginning in the person’s early twenties, i.e. following the second vaccination against smallpox conducted in accordance with the German Reich’s Vaccination Law.

In 1962 Professor Herrlich pointed out that post-vaccinal encephalopathy required a certain period of illness before anatomopathological changes developed in the central nervous system and yet these were barely identifiable externally. He named the main symptoms as hypersomnia with disrupted day-night rhythm, apathy, unmotivated shrill crying, therapy-resistant convulsive attacks.

Without doubt there is an enormous spread to the effect that most children tolerate vaccinations apparently without problems and others suffer severe brain damage with debility, paralysis or epilepsy.

So it becomes apparent that, in the acute stage, encephalopathy is hard to identify, yet produces delayed damage to a large extent. Late sequelae are all the more severe, the younger the child is at the time of injury. Post-vaccinal damage is not generally immediately obvious. The possibility of damage is usually only considered weeks, months or even years later as there are virtually no characteristic medical features to indicate whether the child’s symptoms are the result of vaccination or not. This generally applies to all vaccinations.

Basically there is only one definite hallmark of a post-vaccinal reaction, so-called “arrested development” following inoculation. If a child has developed normally and unimpaired up to a certain time and fairly soon after an inoculation remains at a certain stage or regresses and develops abnormal behaviour, then it can be assumed that the vaccination is the cause.

It is extremely difficult to identify this in infancy where points of development are fluid and where timing cannot be precisely determined; even if it has been admitted by official quarters that post-vaccinal damage may involve few symptoms.

Typical post-vaccinal reactions here are: agitation, tendency to take fright, irritability, uncertain movements and reactions, dazed state even apathy, eating disorders, disturbed sleep, fever, cutaneous reactions, headaches, twitching limbs, convulsive attacks, etc.

French and American studies (e.g. by Dr. Abeltier, Dr. Calmar and Prof. Delore) described changes in emotional state and character in the context of post-vaccinal damage with behavioural disorders such as lack of concentration, impaired learning faculties, aggressiveness, hyperactivity, reduced inhibitory threshold and much more.

Syndromes connected with post-vaccinal reactions:

1. Minimal Cerebral Dysfunction (MCD)

An abundance of detailed material, particularly related to the DPT vaccine, has been available in the USA since 1948 following a study in Pediatrics by Byers and Moll. Following a dramatic cluster of SID syndrome connected with decades of vaccination and reports to the FDA and CDC health authorities (the latter operates a system for monitoring disease following vaccination, the MSIFI), the whooping cough component was withdrawn for the time being, resulting in a marked drop in SID syndrome.

This is a collective term for changes in small children which are difficult to diagnose and which have been described with increasing frequency since the fifties. The frequency with which medical reports are received from countries where vaccination is carried out very early and on a particularly large proportion of children, such as the USA, France, the Netherlands and Germany, is striking.

The most frequent sign of a possible case of hard-to-identify minimal encephalopathy, in children of average intelligence and normal functional capacity, is severe distractibility with inability to focus attention and exaggerated coordinated movements. If the inducement is significantly increased, the child’s emotional state is frail and their staying-power minimal, particularly as regards their memory and ability to learn as they are characterized by extreme restlessness.

The symptoms also extend to delays in speech development. In Germany the number of children who learn to talk very late and have difficulties forming proper sentences is estimated at between 18 and 34%.

In the USA the number of children with learning difficulties increased by over 30% between 1958 and 1980. This increase is debated in connection with three decades of whooping cough vaccination as the number of children with congenital alexia rose by leaps and bounds in a staggered manner.

2. Hyperkinetic syndrome (HKS) or Psycho-organic syndrome (POS)

This describes behavioural disorders which extend beyond those so far mentioned, characterised by hyperactive and uncontrolled behaviour, increased aggressiveness, reduced inhibitory threshold and significant loss of concentration. Instead of “fidgety Phil” here we have “problem children” who are treated with methods based on educational psychology and, in extreme cases, are prescribed psychopharmaceuticals with all the associated risks for their later emotional behaviour and physical activity. The number of children under 12 taking psychopharmaceuticals is around 1.4 million.

3. Autism

4. Allergic diseases

“Autistic syndrome,” first described in 1943 by the American child psychiatrist Kanner, is characterized by disrupted intellectual and speech development, extreme isolation from their surroundings and an anxious, obsessive need to maintain the status quo in their material environment (fear of change).

The condition is suspected to be a consequence of post-vaccinal encephalopathy which was not identified, especially as the cause is known as “infantile cerebral organic damage” in conventional medicine…

Recent decades have witnessed an increase in this group of disorders which is expected to continue further.

Professor Herrlich was the first to point out this connection in the Handbuch der Schutzimp-fungen [Handbook of prophylactic vaccinations]. Later it was the Prenzlau diabetologist Dr. Schneider (1973 and 1975) and also Prof. Stuck 1993 in Padiatrische Praxis [Paediatric practice], volume 1 with the article: “Mumpsimpfung und Auftreten eines Diabetes mellitus Typ la” [Mumps inoculation and the occurrence of Diabetes mellitus type la], in which he described 19 cases connected with mumps vaccination.

In addition to food allergies, allergic asthma and neurodermatitis, hayfever is above all the disease perhaps most associated with infantile inoculation.

Pollen may perhaps be the external cause of this syndrome yet the organism’s immunological sensitivity is the more fundamental process whereby, to appreciate Louis Pasteur’s epidemiology, the underlying principle should be: “Germs are nothing–it is the territory which is important.”

Interestingly, the first reports of hayfever came from England, only a few years after Edward Jenner incorporated foreign protein into the human body.

If today one child in four suffers from some form of allergy, the question must be asked as to whether the process of sensitizing with foreign protein represents not just immune training but possibly also leaves behind a confused “allergic” immune system.

While at that time only two vaccinations were given (at age 2 and 12), from the sixties onwards early multiple inoculations were carried out accompanied by the parallel geographical and sociological occurrence of epidemic hayfever in infants.

5. Immunodeficiency

6. Diabetes mellitus

The increase in children with lowered resistance from the recurrent infections described above, childhood diseases experienced retoxically, multiple bouts of a childhood disease, otitis or tonsillitis as toxic foci and the increase in bacterial and viral resistance.

So far twelve cases of infantile diabetes have been reported in the literature connected with prophylactic inoculation against smallpox.

7. Multiple sclerosis / facial paresis / Bechterew’s disease

Articles 51 and 52 of the German Federal Epidemics Act make statutory provision for a condition to be recognized as “compensable post-vaccinal damage” and a hardship clause is included for disease where evidence of probability cannot be produced, as medical science is undecided as to the cause of the diagnosed condition. This so-called “authorization” was created by the legislator, aware that certain diseases may be provoked by external influences. We talk here of a “trigger mechanism.”

Since viruses, acting as “trigger mechanisms,” are capable of setting the start of these diseases in motion, it is just as possible that vaccines containing viruses or viral constituents can have the same effect.

MS and facial paresis are named in the Federal Epidemics Act and it is pointed out in “Anhaltspunkten fur arztliche Gutachtertatigkeit im sozia-len Entschadigungsrecht und nach dem Schwerbe-hindertengesetz, Ausgabe 1983 [Grounds for expert medical involvement in social compensation law and under the Severely Disabled Act, Edition 1983]” in point 139 “Assessing causality” that Bechterew’s disease also falls under Art. 52, Para. 2.

8. Sudden infant death (SID) syndrome (cot death)

Virtually all infectious diseases have been declining regularly and almost uniformly for decades, yet the so-far unexplained phenomenon of cot death has been increasing continuously, albeit with a slight regression in the last ten years. In 1965 the Leipzig pathologist P. F. Mahnke published his study: “Plotzlicher Tod im Kindesalter und vor-ausgegangene Schutzimpfungen” [Sudden death in childhood and previous prophylactic vaccinations]. The Paul Ehrlich Institute (PEI) published the following statement in numerous medical journals in October 1992: “The PEI is calling for cases to be reported. Death from unknown cause in babies and infants following prophylactic vaccination. The PEI is interested to learn whether deaths of babies and infants from unknown causes have been observed in Germany in the past 12 months, especially following prophylactic vaccination.”

 

*Note, the Back to Sleep Campaign was initiated in 1994. The DTaP vaccine was licensed in 1996 and recommended for routine use, and a year later replaced DTP vaccines in most medical offices.  Yet:

… despite our best efforts to date, SIDS remains the leading cause of death for infants one month to one year of age, claiming the lives of approximately 2,000 babies in the U.S. each year.  Even more alarming is the fact that African American and Native American babies continue to be at 2-3 times greater risk than Caucasian babies….” (See history #3 above)

The SIDS rate has declined but was it due to the Back to Sleep Campaign or the discontinued use of DTP vaccine shortly after?

October 31, 2008 Pediatrics Study:

Health Risk Behaviors in Adolescents With Chronic Conditions

RESULTS. Youth with a chronic condition were more likely to smoke daily, to be current cannabis users, and to have performed violent or antisocial acts. Youth with a chronic condition were also more likely to report 3 or 4 risk behaviors.

CONCLUSIONS. These results indicate that having a chronic condition carries additional risks for engaging in health risk behaviors and emphasize the importance of health risk screening and preventive counseling for young people in general and among those suffering from chronic conditions in particular.

Meningococcal Vaccines Study

Immunogenicity, reactogenicity and persistence of meningococcal A, C, W-135 and Y-tetanus toxoid candidate conjugate (MenACWY-TT) vaccine formulations in adolescents aged 15–25 years. (Vaccine
Volume 27, Issue 1, 1 January 2009, Pages 161-168)

Abstract

Development of meningococcal serogroups A, C, W-135 and Y conjugate vaccines could expand coverage against devastating meningococcal diseases. The immunogenicity of one dose of each one of five MenACWY-TT formulations versus a licensed ACWY polysaccharide vaccine was evaluated in 175 healthy subjects of 15–25 years. Serum bactericidal titers (rSBA) were evaluated before and after vaccination.

The percentage of rSBA responders to each serogroup A, C, W-135 and Y did not statistically differ from the control for each of the five formulations except for serogroup A that was lower after administration of one formulation. In the 3-year follow-up of the first study where the latter formulation was assessed, bactericidal antibody persistence was similar to the licensed ACWY polysaccharide vaccine for MenA and MenC and higher for MenW-135 and MenY.

Our results present five investigational MenACWY-TT conjugate vaccine formulations which are well tolerated and highly immunogenic in adolescents.

1. Introduction

Meningococcal disease due to Neisseria meningitidis remains a major public health problem worldwide due to the associated high levels of morbidity and mortality [1]. In Europe, from 1999 to 2006, the overall endemic incidence rate per 1,00,000 population ranged from 1.1 to 1.9 with the highest age specific incidence rates seen in children younger than 5 years of age, adolescents and young adults [2]. High risk groups include also those who live in crowded conditions, such as college campuses [3]. Mortality rates are generally highest in infants and young children, although very high mortality has also been recorded in adolescents [4]

Five serogroups (A, B, C, W-135 and Y), identified based on capsular polysaccharide (PS) antigens, are implicated in 95% of clinical meningococcal cases [5]. There is substantial regional variation in the relative distribution of each serogroup. In Africa and Asia, serogroups B and C cause sporadic disease, whereas serogroup A, and to a lesser degree serogroup C, are responsible for large-scale epidemics, with highest magnitude in the African meningitis belt [6]. Meningococcal meningitis epidemiology is also dynamic in time: serogroup W-135 has emerged as a new threat after causing outbreaks in Muslim pilgrims in Saudi Arabia and elsewhere, and then in Burkina Faso and Chad [7], [8] and [9]. Serogroup W-135 has now been isolated in numerous countries in Africa [10]; meningococcal disease due to serogroup X has been reported in Niger, where an outbreak occurred in 2006 [11]. In North America, serogroups B, C and Y are the major disease serogroups. By the mid-1990s, serogroup Y accounted for around one-third of all cases in the United States [12]. Cases of serogroup Y invasive disease have also been reported in Canada [13]. In Europe, serogroups B and C predominate, although the latter has been drastically reduced in those countries that have introduced meningococcal serogroup C conjugate vaccination [14].

No broadly protective vaccine exists against serogroup B meningococcal disease but effective vaccines against meningococcal disease due to the other four predominant serogroups are available, including the most recently developed meningococcal conjugate vaccines. Mass vaccination with serogroup C meningococcal conjugate vaccines has proven their effectiveness in all ages [15]. MenC conjugate vaccines are now given routinely in Australia, Canada and in some European countries either as infant vaccination followed by a booster or as a single dose in toddlers. Protection conferred by a single dose in adolescents or toddlers has been shown to last for at least 4–5 years [15] and [16] although bactericidal antibodies wane overtime in those vaccinated below 10 years of age, suggesting re-vaccination in adolescence may be necessary after vaccination in childhood [17]. Substantial reduction in nasopharyngeal carriage of serogroup C (66% reduction in adolescents in the UK [18] after MenC conjugate vaccination) is thought to be a major factor contributing to herd immunity after mass vaccination [19].

A cost-effectiveness study in Canada suggested that re-vaccination with a tetravalent conjugate vaccine would benefit those countries with established MenC conjugate vaccination programmes in light of possible increases in serogroup Y incidence [20]. Only one meningococcal ACWY conjugate vaccine is licensed to date (in the United States and in Canada) and several other meningococcal ACWY conjugate candidate vaccines are in clinical development [21].

This paper presents the results of two studies that evaluated the immunogenicity and reactogenicity of five formulations of a novel, combined MenACWY conjugate candidate vaccine that varied both in the amount of PS and the conjugation method for each serogroup. The vaccine formulations were administered as a single dose to teenagers and young adults.

Continued

Delay and Selective Vaccine Schedules

A list of delay or selective vaccine schedules for parents who prefer this route:

 

Dr. Stephanie Cave’s vaccine schedule:

4 months: start Hib with IPV (polio)


6 months: DtaP started

7 months: second series of Hib and IPV

8 months: second series Dtap

9 months: third series Hib

10 months: third series DtaP

15 months: measles

18 months: fourth series Hib, IPV

19 months: fourth series DtaP

27 months: rubella

39 months: mumps

4-5 years: MMR boosters separate from any other boosters only if no titers for immunity.

4-5 years: boosters for DtaP and IPV if needed

Hepatitis B: If  Mother is not positive and baby is not attending child care we would like to postpone until at least school age and only give if mandated by state.

Pneumococcal (Prevnar): Do not want, only discuss if mandated by state only.

Varicella (Varivax): close to school age if mandated by law and if child is not immune to chicken pox based on blood test. Never before 4-5 years.

MMR: to be given seperately

15 months: measles

27 months: rubella

39 months: mumps

4-5 years: MMR boosters separate from any other boosters only if no titers for immunity.

 

 

This is from Dr. Miller (Generation Rescue)

 

1. no vaccines until 2 years old

2. no mercury containing vaccines

3. no live virus vaccines

4. vaccines to be given 1 at a time starting at age 2-

    a. pertussis

    b. diptheria

    c. tetanus

    d. polio

 

Dr. Sears Selective Vaccination Schedule

 

2 months-  DTaP, Rotavirus

3 months- Pc, HIB

4 months- DtaP, Rotavirus

5 months- Pc, HIB

6 months- DtaP, Rotavirus

7 months- Pc, HIB

15 months- Pc, HIB

5 years- Tetanus booster

10 years- Blood test(Titer) for Measles, Mumps, Rubella, Chickenpox, Hep A                  Consider vaccinating if not immune. Consider 3 dose Polio series if   traveling to Africa or Asia 

11years- HPV (3 doses)

12 years Hep B (3 doses)

 

 

Alternative Vaccine Schedule

 

2 months-  DTaP, Rotavirus

3 months- Pc, HIB

4 months- DtaP, Rotavirus

5 months- Pc, HIB

6 months- DtaP, Rotavirus

7 months- Pc, HIB

9 months- Polio, Flu (2 doses)

12 months- Mumps, Polio

15 months- Pc, HIB

18 months- DTaP, Chickenpox

21 months- Flu

2 years- Rubella, Polio

2.5 years- Hep B, Hep A

3 years- Hep B, Measles, Flu

3.5 years- Hep B, Hep A

4 years- DTaP, Polio, Flu

5 years- MMR, Flu

6 years- Chickenpox

12 years- Tdap, HPV

12 years 2 months- HPV

13 years-HPV, Meningococcal (once meningococcal approved for age 2-recommend at age 2 and delay Hep B for 6 months)

   

(Most people are immune after one dose. We continue to get multiple doses that MAY NOT BE NEEDED. Have them check antibody levels via titres blood test.)

 

 

 DAN! Guidelines:

 

  •  Use Thimersol / Mercury free vaccines!!(THAT INCLUDES vaccines that have multiple viruses! Split them up!)

  •  Use single dose vials from which to draw up the vaccines as opposed to multiple-dose vials which provide less uniform dosage.

  •  Use inactivated polio. (IPV)

  • Give RDA (Recommended Daily Allowances) of Vitamin C before and after vaccines
  •  Give a natural form of Vitamin A ( cod liver oil ) to keep RDA’s at level at all times for the age.

  •  Separate the MMR into 3…start with measles at 12-15 months, then mumps at 18-21 months, rubella at 24-27 months.

  •  Do not give live virus vaccines to immunodeficient children.

  •  Do not give vaccines if allergic to any of these components:

i. Yeast – Hep B

ii. Eggs – MMR

iii. Neonycian – MMR or Varicella

  •  Hold off on the Varicella until 10-12 years & if the child is shown not immune to Chicken pox.

 

  •  Checking vaccine titers before giving boosters

 

 

Bringing Chickenpox to the Boil

Bringing Chickenpox to the Boil

by Hilary Butler

Avid readers of dramatic novels from yesteryear will recall stories from the days when fevered patients were watched over by family, and the oldies in the group just “knew” that a proper fever would “break” with a sweat. When that happened, they knew that the prognosis would be good. Of course, such sentiments today would be greeted with alarm, or scepticism, by those who consider illness should never be endured.

Isn’t that why acetaminophen (in all their different brand names) is reached for, at the first sign of a fever?

In 2001, a headline

1 made me look twice. “Sweat has the power to fight off disease.” We were told that sweat contains a versatile antibiotic that may be on the front line against disease-causing bacteria and that: “The researchers said dermcidin probably plays a key role in the innate immune responses of the skin”.  A news roundup from the British Medical Journal told us2 that dermcidin killed escherichia coli, enterococcus faecalis, staphylococcus aureus and Candida albicans. It was active at high salt concentrations and the acidity range of human sweat. In concentrations of 1–10 μg/ml, it killed all of the staph aureus colonies in only four hours. Unsurprisingly, the scientists didn’t know how dermcidin worked.

Up until the late 1990s the skin was simply thought to be a “barrier” with no active participation in the immune system. The original 2001 paper

3 said that during some inflammatory skin disorders and wound healing, skin cells functioning within a salty sweat with a pH of 4–6.8, produced many effective pharmacologically active substances, such as immunoglobulin A, interleukin 1, 6 and 8, tumour necrosis factor, transforming growth factor β receptor, epidermal growth factor, and a prolactin-inducible protein.

As time has gone on, other researchers have taken a closer look at skin, and have found that the neutrophil,

4 which is the professional phagocyte of fundamental importance for defence against micro-organisms, provides instant help, not only in microbial infection,5 but to the growth factors when the skin is broken and there is a risk of infection. Another article6 says that mast cells, macrophages and skin cells produce antimicrobial peptides. These are called cathelicidin, which disrupts bacterial cell walls, modifies the host cells inflammation, and provides additional immune defence. At the heart of this all, is our friendly neutrophil:

“These studies clearly illuminate the importance of neutrophil recruitment in cutaneous defense against bacterial infection. … Recent advances in understanding of innate immune defense systems have suggested that these ancient evolutionary immune mechanisms may be important to human disease yet previously underappreciated.” (Underlining mine)

The article looked at whether just skin and mast cells were involved, or whether neutrophils were also important. Using mice, they found that mice with few neutrophils developed much worse tissue death (necrosis) and had 3,000 times the amount of bacteria on the skin than mice with active neutrophils. The skin cells worked hard and could produce some cathelicidin on their own, but didn’t have the killing power of the skin cells plus neutrophils. The article’s conclusion said that life-threatening necrotizing skin and soft-tissue infections can develop in patients with depressed neutrophils, but that numerous examples exist of patients with increased frequency of skin infections who have no

“demonstrable defect 7 in leukocyte recruitment or function.”

Properly fed, healthy children, whose parents know what to do, and what not to do, will rarely get any complications to chickenpox. As was the case for our children, well-managed chickenpox should not even lead to any scarring. So let’s ask some questions here, with chickenpox in mind. What is the function of fever?

Here’s a really simple statement11 from twenty years ago: “… elevated body temperature enhances the infl ammatory response and function of the immune system at the same time that it reduces the replication of microbes and tumor cells.”

 

 

 

 

Not so simple is this sentence.

 

“Fever also appears to be a prominent component of cytokine therapy and attends the use of several biologic response modifiers.”

Fever switches on the chemical messengers and processes which call on the body immune system to respond and “modify” or deal with the infection.

If fever is a key to an immune-system process, without a fever, how effective is the body going to be in fi ghting viruses, or bacteria? With viruses like chickenpox, which are known to have an affinity with

 

group A streptococcus,

which can infect the pox rash and so have access to the body, what do we want the immune system to do? It’s pretty obvious isn’t it?

We

 

want

to allow the body temperature to rise to the level it needs so that all the on-switches can be thrown.

We

 

want

the body to send out all those little chemical messengers which get the antiviral side of things going.

We

 

want the messengers to call the neutrophils to join the skin cells in producing cathelicidin, and to work with the whole array of anti-viral and antibacterial components12 in “sweat” to stop group A streptococcus

in its tracks.

As a 1991 article13 says: “… temperature elevation … enhances the processes involved in initial antigen recognition and support for immunological specifi c response to challenge.

We want the body to recognize the virus, ring the bell and sound the red alert (fever) to fight, don’t we? Why, then, turn the fever off with acetaminophen products? Doesn’t that defy logic?

Another article14 of that era said: “There is considerable in-vitro evidence that a variety of human immunological defences function better at febrile temperatures than at normal ones … Studies have clearly shown that fever helps laboratory animals to survive an infection whereas antipyresis15 increases mortality.”

A 1998 article16 said: “The elevation of body temperature by a few degrees may improve the efficiency of macrophages in killing invading bacteria, whereas it impairs the replication of many microorganisms, giving the immune system an adaptive advantage. There is a simultaneous switch from the burning of glucose, an excellent substrate for bacterial growth, to metabolism based on proteolysis and lipolysis. The host organism is anorectic (doesn’t want to eat) minimizing the availability of glucose, and somnolent, reducing the demand by muscles for energy substrate. During the febrile response, the liver produced proteins known as acute phase reactants … the net effect … is to give the host organism an adaptive advantage over the invader.” (Underlining mine.)

Treating fevers is dicing with more severe infection, and a greater likelihood of death, because fever is a key immune response to get the immune system working properly.

You mess with fever, and you mess with lots of things. It stands to reason. Do you need to know what the medical profession does not yet know about fever in its totality, to see that?

 

Back to chickenpox. Tucked away in a small co

 

rner of the New Zealand Herald in 2001 was a warning:17 “GPs warned over chickenpox drug.” Doctors were warned about treating chickenpox with ibuprofen to reduce fever because of a higher rate of necrotizing fasciitis18. There was no mention of paracetamol in the warning, yet, since both perform the same function, there is reason to argue that paracetamol might do the same as ibuprofen. In USA, the link between the use of non-steroidal anti-infl ammatories and chickenpox reached the ears of doctors,19,20

but not, it seems, the public.

There was a flurry of articles suggesting it was dangerous to use anti-febrile drugs with chickenpox; there was also an article by a group of doctors, who in defiance of all logic and known immunological impacts of drugs used to reduce fever, decided that there was no association. They

 

21

decreed that when parents used drugs to “treat high fever and severe illness”, drug use was merely the identifying factor of who was at high risk for secondary bacterial infection! That interesting little word “coincidental” again.

… I see the increase in these infections as evidence of a total lack of common sense about how to prevent complications. I see the association between nonsteroidal anti-febrile drugs and GAS as a predictable outcome of the loss of home nursing skills and handed-down generational wisdom. I see the increase in secondary bacterial infections as something which can stem from parental lack of understanding that messing around with fever, and using symptom-suppressing/immune-suppressing drugs can restrict the ability of the immune system to fi ght the virus. It also reduces the ability of the leucocyte system of neutrophils, macrophages and phagocytes to fight bacterial toxins from secondary bacterial infections.

As pointed out in Chapter 70, if you don’t have enough vitamin C in your system, then the neutrophils won’t be recognized by the macrophages, and you might be in big trouble, because if that happens, the result could be toxic shock/sepsis taking hold very quickly. Even if you have enough vitamin C, if the amount of GAS toxin is such that the glucose transporters (which are part of the vitamin C shuttle service which takes ascorbate from A to B) are blocked, that can result in a GAS infection which threatens to run out of control. The quickest way to restore the immune function in a case of sepsis is by giving vitamin C intravenously. The body can fight sepsis by itself, but it’s a bit more of a lottery as to whether it will succeed if it doesn’t have the tools to do the job.

BOOK: From One Prick to Another

 

A Government Call for Vaccine Research

A Government Call for Vaccine Research

The National Institutes of Health has put out a call for answers

Posted December 11, 2008

The way to cool the hot debate on vaccine safety is to turn to science and get the facts, and here, there is reason for optimism. Last August, the National Institutes of Health embarked on an effort entitled “Research to Advance Vaccine Safety,” involving five of its institutes plus the CDC. The operating premise: Vaccines are of vital importance to human welfare, and new and better technology enables researchers to address as never before gaps in knowledge about how to use them more safely and effectively. Areas the NIH wants to see tackled include:

Vaccine response. Vaccines do more than stimulate antibodies. Yet there is scant research on the way the complex networks of specialized white blood cells and immune chemicals behave in response to the currently licensed vaccines and their assorted nonvaccine components. Reactions vary among children and those of different ages, and sometimes, vaccines can induce overly sensitive immune reactions. Studies showing that early childhood vaccination may promote chronic allergies, for example, beg for further research.

Susceptible groups. The recognition that vaccines can be unsafe for some children made headlines last spring when experts determined that Hannah Poling, who had an unknown mitochondrial disorder, suddenly and dramatically developed autism as a toddler in reaction to nine immunizations administered at once, validating many parents’ concerns. Recently, serious complications from the new smallpox vaccine have been tied to specific gene variations, and there is ongoing concern that rheumatoid arthritis and other autoimmune conditions have been triggered by the hepatitis B vaccine in those with genetic susceptibility. The NIH wants to identify risk factors and biological markers predictive of adverse reactions, which could protect vulnerable groups and allow better clinical trials.

Vaccine schedules. The one-size-fits-all vaccine schedule has served the public well but has yet to be tested for optimal efficacy and safety. The NIH proposes comparisons of the immunologic and physiologic effects of different combinations of vaccines administered on different schedules. Supporting this need is a 2008 Canadian study that found that delaying the diphtheria, pertussis, and tetanus vaccination a few months cut the risk of childhood asthma by 50 percent.

Immune capacity. As infants leave the womb’s sterile environment, their immune system is virtually a blank slate, soon molded by generally benign and natural exposures—to pollen in the air, proteins in food, microbes on their mother’s skin. It’s assumed the little ones can handle with the same ease a sudden and concentrated exposure to the less benign antigens in vaccines. Research on the capacity of the young immune system to do so needs further investigation, particularly with the flood of new vaccines on the horizon.

Dr. Healy formerly headed the NIH.

Research halted at Seattle hospital

Research halted at Seattle hospital

Officials have halted enrollment in more than 600 human research studies taking place in Seattle this week after a federal audit found shoddy paperwork in some consent forms.

The Department of Veterans Affair’s Office of Research Oversight determined in a November audit that the VA Puget Sound Health Care System should be more careful in documenting that human subjects are competent enough to make reasoned informed consent. Local oversight committees were also censured for not formally judging risk levels on a study by study basis.

 
 

“This is a procedural issue,” Norm Arkan, a University of Washington spokesperson, told The Scientist. “There were no issues here of any subject being in jeopardy with regard to safety issues.”

“There were administrative oversight issues, and we’ve begun the process of making changes,” added Jeri Rowe, the VA Puget Sound Health Systems’ director of public affairs.

Researchers can continue collecting data from patients already enrolled in ongoing studies but cannot add new subjects or publish any results until the hospital cleans up its documentation methods, according to the Seattle Post-Intelligencer.

The decision applies to about 600 studies being conducted at the hospital and at the University of Washington, and 15 studies at the Fred Hutchinson Cancer Research Center that were actively recruiting bone-marrow transplant and oncology patients at the hospital.

Arkan expects that the studies will now be delayed by “several weeks.” In the meantime, researchers may have to turn to data analysis and other minor research-related tasks until the wrinkles are ironed out. “The biggest impediment,” he said, will be that “our researchers have a lot of paperwork to fill out,” but the research will resume eventually.

Chicken Pox cases in older children

Officials: Update chicken pox vaccine


Health officials are stumped as to why an outbreak of chickenpox has sickened more than 40 students at Spruce Creek High School — but they are taking steps to contain it, urging all parents to update their children’s vaccines.

The outbreak has affected just 1.5 percent of the school’s 2,700 students, but it’s been serious enough to warrant the Volusia County Health Department’s involvement as it’s become more serious since the first case was reported in September.

After 30 cases were reported this month, a third automated call went out to the homes of all Spruce Creek High School students Thursday night warning families to keep at home children who are showing signs of the illness that causes blistering and fever.

Today, parents will receive a letter detailing steps to take to ensure children are fully vaccinated.

The puzzling part for officials is that the chickenpox vaccine has been required for entering Volusia County schools since 1995 — about the time today’s high school students started school. Dr. Sanford Zelnick, the Health Department’s medical director, said he believes it’s a result of how the varicella virus that causes chickenpox is evolving.

“It’s hard to postulate why this cluster began,” Zelnick said, pointing out that the Centers for Disease Control began recommending in 2007 that children receive a booster chickenpox vaccine after their initial one. “What I can tell you is that other communities in the United States have noticed this gradual shift of varicella (chickenpox) moving into later childhood.”

The disease kills about 100 people a year, Zelnick said, but most of the time it just puts someone out of commission for four to seven days, causing a rash and a fever.

According to the Centers for Disease Control, one dose of the vaccine is about 80 to 85 percent effective. Following the CDC recommendation of a second dose in 2007, the Volusia County school district required the second dose for entrance into pre-kindergarten through sixth grade starting this year, said Nancy Wait, school spokeswoman.

Pediatrician Andrea Thorpe, who practices in Daytona Beach, said she recently had an 11-year-old patient who came down with chickenpox in spite of receiving his vaccination in 2001.

“He had a 104 fever, itching all over, covered (with the rash) from head to toe,” she said. “When you’re older and you get it, you get it bad. It’s miserable.”

*************

See Trading Places

Lancet: Dozens of nations inflated vaccine numbers

Lancet: Dozens of nations inflated vaccine numbers

LONDON – Dozens of developing countries exaggerated figures on how many children were vaccinated against deadly diseases, which allowed them to get more money from U.N.-sponsored programs, a new study said Friday.

Research in the medical journal, The Lancet, said only half as many children were vaccinated than was claimed by countries taking part in special programs meant to reach kids in poor nations. The findings raise serious issues about vaccination programs — and whether money earmarked for children is actually reaching their intended recipients.

“With the unprecedented billions given by the international community, there is no excuse for these poor coverage rates,” said Philip Stevens, of the International Policy Network, a London-based think-tank. “One has to wonder where the money has gone — hopefully not into Swiss bank accounts.”

American researchers analyzed records of children supposedly vaccinated by initiatives led by the United Nations and related groups like the Global Alliance for Vaccines and Immunization, or GAVI.

The scientists examined reports the countries gave to the United Nations on how many children were immunized. They then compared those figures to independent surveys on vaccination conducted by non-governmental groups and other outside researchers.

The report did not focus on the tens of millions of children immunized globally each year. Instead, the researchers studied programs meant to increase the availability of vaccinations in poorer countries — vaccinations designed to reach kids who would not be covered otherwise.

From 1986 to 2006, the United Nations reported that 14 million children received immunizations in the programs. But the reports from the independent surveys put that number at just over 7 million.

“The magnitude of the gap is surprising,” said Christopher Murray, director of the Institute for Health Metrics at the University of Washington and the study’s lead author.

Murray and colleagues found that at least 32 of the 51 countries taking part in the U.N.-backed programs over-reported by at least 50 percent how many children were protected against diphtheria, tetanus and whooping cough.

Experts suggest that inflating the numbers is part of a larger problem in attracting limited resources.

“That’s how you get money,” said Ken Hill, a public health professor at Harvard University who was not linked to the study. “You exaggerate the number of people who die or who you save to get visibility. Somehow, numbers always end up bigger than they would be otherwise.”

The global alliance pays developing countries $20 per extra vaccinated child — a payment that relies exclusively on reports from the countries.

Murray and colleagues estimated that the alliance should have paid countries $150 million. Instead, it paid them $290 million.

The report said the worst countries for over-reporting were Armenia, Somalia, Zimbabwe and Myanmar, none of which immunized any additional children at all.

Countries that reported vaccination numbers more than four times higher than surveys showed included Tajikistan, Pakistan, Togo, Lesotho, Liberia and Zambia.

Those overestimating immunizations by more than two times were Niger, Ivory Coast, Congo, Central African Republic, Guinea, Indonesia, Gambia, North Korea, Chad and the Democratic Republic of Congo.

Nations that claimed at least 50 percent more vaccinations than were actually done included Afghanistan, Burkina Faso, Mali, Sudan, Uganda, Tanzania, Ethiopia, Rwanda, Ghana, Azerbaijan, Cameroon and Nepal.

Experts said the study raised questions about the credibility of other health data from the United Nations and countries.

Julian Lob-Levyt, the chief executive officer of the global vaccines alliance, said it would hold off on all payments until affected countries can clarify what is happening in their programs.

He also stressed that there was no evidence of corruption in any of the countries that had received money from the alliance.

Some experts worry that the Lancet study, which was paid for by the Bill & Melinda Gates Foundation, overstated the problem and that immunization programs would be unfairly overhauled.

The United Nations has been criticized for its fluctuating figures in the past. In 2007, it dramatically slashed its HIV figures, citing new surveillance methods.

************

Have they stopped to think that many parents do NOT want those vaccines. They are hiding their children to keep them from being vaccinated, they are bullied, coerced and other. And dare we mention their clinical trials where these children are used as guinea pigs. Yes, the corruption goes on, inflating numbers has always gone on. This isn’t new news.

Also see:

Massachusetts Gift-Ban Bill Causes Another Ruckus

 St. Petersburg Times – “Drug makers spend hundreds of millions of dollars bringing a promising compound to the stage where it can be tested on humans — only to be stymied when subjects in developed countries are slow to sign up. So the companies have moved offshore in search of subjects, and now nearly half of all studies are conducted outside the United States. Brazil, Russia and China have been popular trial locales, but India is moving up fast, aggressively courting the drug study business.”

Chicken Pox/Shingles Treatment

Chicken Pox/Shingles Treatment

 

 

 

 

  •  Vitamins A and C are the vitamin treatment of choice. Chickenpox can require large doses, but Shingles requires much larger doses. Selenium and Zinc are also beneficial.
  • Avoid sugar and undiluted fruit juices.
  •  
  • Keep the skin clean and cool with frequent baths using 1 cup baking soda or 5 drops lavender essential oil in the bath water. Rubbing the juice from the fresh stems of aloe vera can also help the itching. Cider vinegar neat, used as compresses, changes the skin PH and when held against the pox spots can kill surface virus particularly where the blister is broken. No pox virus can survive a ph of 3.
  • An oil mix, for adults, is bergamot, chamomile, eucalyptus, geranium, lavender, lemon and tea tree oil… as above, or dilute them by adding 5 drops each to a couple of tablespoons of vegetable oil and apply them directly to rash if painful.
  • Epsom salts baths with oat straw/oatmeal-one cup per bath in a bag, hung under the hot water tap, and then float it, for children who are tense and itchy.
  • Echinacea and goldenseal combination helps prevent bacterial infections of the sores. So can Calendula (1 tsp tincture – 4 tsp water)
  • For severe, Lysine (an essential amino acid) inhibits replication of both chickenpox and shingles. Use 2,000 mg a day as a supplement (or smaller doses in children). Lysine works by blocking the virus’s ability to absorb arginine.
  • For pain in both children and adults, often the person is vitamin B deficient. For shingles in older adults, if nerve pain is severe B12 injections along with some of the others orally can relieve the pain, and shorten the course of illness.
  • If a bacterial infection looks like its setting in, a capsule of Transfer Factor may help. Breast milk, if available, may do the same.
  • Shingles is triggered by stress, and stress pulls out huge amounts of B-vitamins from the body. People with shingles need B supplementation.
  • For both chickenpox and shingles in adults, Hydrogen Peroxide gel, every 2 – 3 hours helps dry and heal blisters.
  • Alpha Lipoic acid is another some doctors prescribe for shingles in adults. It’s an antioxidant, and helps keep the scarring of both chickenpox and shingles to a minimum. It may affect blood sugar levels, so use with care with diabetics.
  • Pharmaceutical treatment for shingles is dependent upon symptom alleviation using drugs like prednisone and acyclovir.
  •  Mint tea made with lemon balm or other mints may be beneficial: hyssop, oregano, peppermint, rosemary, sage, self-heal, spearmint or thyme. These are antiviral, anti-herpetic compounds. If there are spots in the throat, you can add licorice root. You could mix it with pear juice which is rich in antiviral caffeic acid.

 

DTaP Side Effect: Autism. Now You See It. Now You Don’t.

*update:

Age of Autism

VHCN  _the page that is now under revision you can view here.

Cervarix

CERVARIX Human papillomavirus (HPV) vaccine

“This report summarises the adverse reactions suspected to have been caused by Cervarix human papillomavirus (HPV) vaccine in the UK. This includes reports received between 14 April 2008 and 3rd December 2008.”

 Suspected Adverse Reaction Analysis (pdf)

Unpasteurized Milk: A Continued Public Health Threat

rawmilk

Unpasteurized Milk: A Continued Public Health Threat

Although milk and dairy products are important components of a healthy diet, if consumed unpasteurized, they also can present a health hazard due to possible contamination with pathogenic bacteria. These bacteria can originate even from clinically healthy animals from which milk is derived or from environmental contamination occurring during collection and storage of milk. The decreased frequency of bovine carriage of certain zoonotic pathogens and improved milking hygiene have contributed considerably to decreased contamination of milk but have not, and cannot, fully eliminate the risk of milkborne disease. Pasteurization is the most effective method of enhancing the microbiological safety of milk. The consumption of milk that is not pasteurized increases the risk of contracting disease from a foodstuff that is otherwise very nutritious and healthy. Despite concerns to the contrary, pasteurization does not change the nutritional value of milk. Understanding the science behind this controversial and highly debated topic will provide public health care workers the information needed to discern fact from fiction and will provide a tool to enhance communication with clients in an effort to reduce the incidence of infections associated with the consumption of unpasteurized milk and dairy products.

Continued (fulll article)

*****************************

Having grown up on raw milk, eggs, vegetables we grew ourselves, and eating meat from the animals we raised ourselves, and venison, I strongly disagree. There are children who can not drink pasteurized milk but do fine on raw milk from cow, goat, or other.

I have to wonder if cows  today, receiving vaccines and or antibiotics, are still milked as usual and its being sold and pasteurized that way. Anyone know the current laws on that?  When I was a child, a cow’s milk while on antibiotics could not be added to the milk tank and sold. We drank it as a family anyways and obviously did not get sick.

Encephalitis and Encephalopathy (part 2)

jigsawheadhh

All of my children had the DTP vaccine, with the exception of one, who had the DTaP. I can still remember to this day, and it goes back 18 years ago, dreading the ‘shot day’ when I knew they were going to get a DTP or DTaP. I told a nurse before the injection of one of my children, “I hate this shot.” She asked me why. My response was “Because they cry and scream for days afterwards, run fevers, and are not themselves for weeks.”  Her response? She raised her eyebrows but said nothing! I can also remember calling the doctor’s office once regarding a concern I had days after the DTP vaccine was given and how my child was acting. Their response? “It’s normal. Give him some Tylenol. He will be fine in a few days.”

 

How many parents are still told this today? Problem was he was never ‘fine’ and neither were the rest of them with the exception of one, who is not fully vaccinated according to the CDC recommended schedule. To this day they suffer from one chronic illness or another such as asthma, allergies, bowel issues, severe eczema, and a learning disability. Their chronic illnesses are simply seen as ‘typical’ and ‘normal’ in children today. When my youngest child started public school and has no chronic illness, I was told by a school nurse, “…that’s very unusual today.” Funny thing is, when I was growing up, it was unusual to have any of the above mentioned!

 

I witnessed the first upward shifts in chronic illnesses in very young children in the late 1980’s in daycare centers. There was always at least one infant (8 in a room) or toddler (12 in a room) in a daycare center room that suffered from a chronic illness. I recall the Director at the time said, “I don’t understand what is happening to these children today. Kids were much healthier years ago…” I agreed and at the time I didn’t understand it either. It certainly didn’t get better, but much worse. Diabetes, asthma, allergies, hearing and eye problems, learning disabilities, enuresis and encopresis, behavioral issues, autism spectrum disorders, and the list goes on. So what had happened to those children, and children of today, and children who go on to be adults? How does this relate to encephalitis or encephalopathy?

 

To answer those questions, we need to go back and look at the history. History in regards to vaccines; can tell us what has already taken place, what has been done and why, what the positive or negative effects were and why, and change the direction or path we are on if needed. Unfortunately, changing the path for the overall health of all, simply hasn’t worked that way.

  

Let’s take a look at some of the DTP and DTaP history:

 

The True Story of Pertussis Vaccination.  A Sordid legacy?

(This article explains the history of whooping cough vaccination. The Journal of the History of Medicine and Allied Sciences (57:3, July 2002) awarded it the best article published in 2000, 2001 and 20002, and thus won the 2003 Jackson prize.)

 

Excerpts:

 Page 249: 

image1 

 (End quote)

 In the mid 1960’s, most states mandated the DTP vaccine be given as a prerequisite to entering school. And thus:

 

Page258-260: 

image2

image3 

  Page 282-283:  

 image4

The Hygienic Care of Children by Herbert M. Shelton states: (bolding mine)

The New York State Journal of Medicine, May 15, 1926, carried two articles from foreign Journals discussing similar cases on the European continent. In one of these Carl Leiner, (Vienna) is said to have discussed encephalitis and meningitis developing in nine to fifteen days after vaccination. He admits that in a generalized infection, like generalized vaccina, there may be intracranial complications. The article also states that Dr. Lucksch saw three cases and knew of four more, and of the seven children, five died. In two autopsies, which he obtained, he was able to show beyond doubt that “death had been due to encephalitis.” Bastianse, of the Hague, collected notes of 34 similar cases which occurred in Holland during 18 months of 1924–25, with a mortality of forty per cent–“deadlier if anything than ordinary epidemic encephalitis.” “In addition several cases of serious meningitis have been reported.”

Three cases reported, by the author of the article, in Austria, showed that “not only the encephalon but the cord and peripheral nerves may be involved, so that the affection may be spoken of broadly as a meningoencephalitis polyneuritis.”

The other article is a brief of an article by Dr. W. F. Winkler, chief of the University Clinic of Rostock. It says: “Quite recently isolated cases of cerebral symptoms, suggesting encephalitis, following vaccination have been reported from Holland, Czechoslovakia, and Germany and from Switzerland there have been reported two cases of serious meningitis.”

The Netherlands, and other countries, for instance, France, have also reported cases of this kind. In the Journal of the American Medical Association, July 3, 1926, P. 45, is an article by its Berlin correspondent discussing “Nervous disturbances and Smallpox Vaccination.” In it are these words: “In regions in which there is no organized vaccination of the population, general paralysis is rare. In patients with general paralysis he (Dr. Daraskwiewicz), has never seen smallpox scars, but vaccination scars were always present.” It is noted that, whereas, boys are most susceptible to post-vaccinal tetanus, girls are most susceptible to post-vaccinal encephalitis.

(See also Neurologic Adverse Events Associated With Smallpox Vaccination in the United States, 2002-2004)

 

…Dr. Pierre Baron, Ancien Intern of the Hospitaux de Paris, prefaces his work on post-vaccinal encephalitis (1929), in which his conclusions are based on his own observations, by a case he found after searching through medical annuals and unearthed a report of a case in the “Archives tie Medicine des Infants,” in 1907. Dr. Combay of the Medical Society of the Hospitals of Paris, reported a case which had occurred in his practice in 1905.

Dr. Comby tells of a baby girl, in excellent health when vaccinated at four months of age, who developed convulsions on the eighth day, followed by strabismus and other troubles. She did not die but was left with an “important sequel.” She no longer recognized her surroundings; almost forgot how to nurse; had a vague look; “veritable intellectual obnubilation,” developed idiocy with progressive cerebral sclerosis (hardening of the brain), and nearing her eighteenth month died. Her death went into medical “statistics” as due to pneumonia–and old trick in hiding their crimes.

Dr. Baron’s book discusses 255 cases of post-vaccinal encephalitis, avowedly discussed as such in medical works. His list is far from complete, for he credits the United States with only four cases, all of these before 1927.

Great Britain appointed two committees to investigate this matter–the Andrews Comittee, appointed Nov. 1923, which made its report May 1925; and the Rolleston Committee appointed Feb. 1926, which made its report Feb. 1928. These two committees were composed of eminent medical men all of whom supported vaccination.

The Andrews Committee reported 62 cases of post-vaccinal encephalitis with 36 deaths–40 females and 22 males; average age 10-1/2 years. Four cases were under one year, one case fifty years, and forty-eight cases were from six to sixteen years. Government vaccine had been used in 53 of these cases, of which 30 were fatal.

The Rolleston Committee reported 30 cases with 16 fatalities. Government vaccine was used in 18 of these with 8 deaths. This committee also reported the subsequent history of 10 non-fatal cases under 15 years, showing that 4 were permanently injured in some way–in mind, memory, temper, vigor, relapse.

Since vaccination was made compulsory in England and Wales one million infants have died of convulsions, tetanus, encephalitis, meningitis, and other nervous ailments. How many of these were due to vaccination there is now no means of knowing, but in the light of present facts, we are safe in assuming that a large proportion of them died from this cause.

The Hygienic Care of Children by Herbert M. Shelton part 5: (bolding mine)

It declares that encephalo-myelitis following vaccination always exhibits more extensive lesions than those of sleeping sickness and that “histologically, the inflammation in ordinary cases of poliomyelitis (infantile paralysis) differs conspicuously from that following vaccination.

In 1923, 1924 and 1925 great efforts were made in England to have everybody vaccinated. Thousands of vaccinations were performed. There occurred a great increase in the cases of Encephalitis-Lethargica. In 1924, there were 6,296 cases of this and similar affections reported in England and Wales, with a population of 38,746,000; or 162 cases per million of population. In Liverpool, with a population of 836,000 there was reported 257 such cases; or 306 cases per million of population. Liverpool was fifty per cent better vaccinated than the average of England and Wales, and had almost 100% more Encephalitis. I presume this was due to an “intercurrent affection,” or a “latent infection,” or to a “secondary infection.”

The Hygienic Care of Children” by Herbert M. Shelton part 7: (bolding mine)

The League of Nations in its Report of Aug. 27, 1928 mentions 139 cases and 41 deaths in Holland. This resulted in Holland stopping compulsory vaccination during 1920-29. The total number of vaccinations in Holland in the first half of 1928 was less than one- third of those for the first half of 1927 and the deaths from Encephalitis were reduced to less than one-third.

Germany is seeking a modification of her compulsory vaccination law. She is seeking an optional clause, such as the one England has. The International News Service, Feb. 27, 1930, informs us:

“The change of attitude of some medical experts towards vaccination in favor of a less rigid enforcement of the law has been brought about mainly through a considerable number of post-vaccinal diseases observed in Holland and England and in sporadic cases in Germany.

“Vaccinated people developed a sort of cerebral inflammation, (encephalitis post-vaccinalis) ### which resulted in a number of deaths and in several cases of a mild form of mental derangement.”

Here is part of an item which appeared in the Journal of the American Medical Association for April 5, 1930: “Reisch reports that following the vaccination of 233 children aged between 5 and 10 years, several cases with encephahtlc symptoms were observed. Two were especially severe and ended fatally. The necropsy revealed the changes characteristic of encephalomyelitis. Six other children also developed encephalitic symptoms from six to twelve days after the vaccination.”

The Report of the Commission of Smallpox and Vaccination of the Health Organization of the League of Nations, Geneva, Aug. 27, I9z8, says: “The post- vaccinal encephalitis with which we are dealing has become a problem in itself mainly in consequence of the events of the last few years in the Netherlands and England and Wales. In each of these countries the cases which have occurred have been sufficiently numerous and similar to require them to be considered collectively. Their occurrence has led to the realization that a new, or at least a previously unsuspected or unrecognized, risk attaches to the practice of vaccination.”

 

While other countries took the necessary precautions, initiated investigations, and amended their mandates, the United States did nothing except lie, cover-up, and hide their heads in the sand.

 

This very year (1930) Julia Motley, age 12 of Irisburg, Va., died of acute infantile paralysis which “seized” her 3 weeks after she had been vaccinated. Her parents attributed her death to vaccination, whereupon the State Health Autherities came to the rescue of vaccination. The News Leader, Richmond, March 28, 1930 says: “While the parents gave vaccination as the cause of death, Dr. J. V. Shackleford, the physician, states that the death certificate (made out by him, of course), shows that the little girl died of acute infantile paralysis, with which she was seized three weeks after she had been vaccinated.”

And that’s that! The doctor who vaccinated the girl makes out the death certificate to shield himself and the vaccine and the matter in settled. The girl is now immune to smallpox and the smallpox goddess has been appeased.

 

The Hygienic Care of Children book, by Herbert M. Shelton. Part 8:

…One British Physician said:  “In certificates given by us voluntarily and to which the public have access, it is scarcely to be expected that a medical man will give opinions which may tell against or reflect upon himself in any way, or which are likely to cause annoyance or injury to the survivors. In such cases he will most likely tell the truth, but not the whole truth, and assign some prominent symptom as the cause of death. As instances of cases which may tell against the medical man himself, I will mention erysipelas after vaccination and pueperal fever. A death from the first cause occurred not long ago in my practice, and although I had not vaccinated the child, yet in my desire to preserve vaccination from reproach, I omitted all mention of it from my certificate of death.”

Eleanor McBean also states: “The United States Public Health Bureau is extremely reticent about reporting diseases caused by vaccination but the report from 1922 to 1931 admitted that there had been 85 cases of post-vaccinal encephalitis, which DeKruif states “is the twin of infantile paralysis.”

Many of the mothers noticed that their children had a high-pitched cry soon after their vaccination or vaccinations. This is called the encephalitic cry, meaning that it is caused by an inflamed, swollen brain. It also explains the difficulty many mothers have in waking their children, the vomiting, passing out and irritability following vaccinations. These are all signs of an inflamed brain. The reason that pediatricians are telling these mothers that their children’s reactions to these vaccines are normal is based on at least two factors. One, most pediatricians, in my experience, know absolutely nothing about a child’s brain. When I was practicing, if anything happened to a pediatrician’s patient that in any way indicated something was wrong with the child’s brain, the doctor was on the phone with me in an instant. Most admitted they knew nothing about the brain. The second reason is that they are trying to avoid a lawsuit. If they can convince the mother that everything is well, they may avoid a trip to the courtroom. Most physicians are gun shy about lawsuits. It can also hurt their reputation. Vaccine Safety Manual  by Neil Z. Miller. Preface.

 

Pertussis Vaccination: Use of Acellular Pertussis Vaccines Among Infants and Young Children Recommendations of the Advisory Committee on Immunization Practices (ACIP) (1997)

Concerns about the safety of whole-cell pertussis vaccines prompted development of acellular vaccines that are less likely to provoke adverse events because they contain purified antigenic components of Bordetella pertussis. Two diphtheria and tetanus toxoids and acellular pertussis (DTaP) vaccines — ACEL-IMUNE{Registered} * and Tripedia{Registered} ** — have been licensed for several years, but (until recently) only for administration of the fourth and fifth doses in the series to children aged 15 months-6 years who previously had received three or more doses of diphtheria and tetanus toxoids and whole-cell pertussis (DTP) vaccine. Published reports indicate that, when administered to infants aged 2, 4, and 6 months, acellular pertussis vaccines are effective in preventing pertussis disease and associated with fewer local, systemic, and certain more serious adverse events than whole-cell pertussis vaccines. On the basis of these data, the Food and Drug Administration (FDA) has licensed three DTaP vaccines for use among children aged 6 weeks-6 years. Tripedia{Registered} is now licensed for the initial four doses, and ACEL-IMUNE{Registered} for all five doses of the diphtheria, tetanus and pertussis vaccination series. A third DTaP vaccine (Infanrix TM) *** was licensed in January 1997 for the initial four doses of the series. Tripedia{Registered}, ACEL-IMUNE{Registered}, and Infanrix TM are now recommended for routine vaccination of infants and young children, although whole-cell pertussis vaccines remain acceptable alternatives…

Efficacy:

The efficacy of three doses of acellular pertussis vaccines in preventing moderate to severe pertussis disease was within the range expected for most whole-cell DTP vaccines. Point estimates of efficacy ranged from 59% to 89%. Mild local and systemic adverse events occurred less frequently among infants vaccinated with acellular pertussis vaccines for the first three or four doses than among those vaccinated with whole-cell DTP. More serious adverse events (e.g., fever greater than or equal to 105 F {greater than or equal to 40.5 C}, persistent crying of greater than or equal to 3 hours duration, hypotonic hyporesponsive episodes, and seizures) generally occurred less frequently among infants who received acellular pertussis vaccines than among those vaccinated with whole-cell DTP. The number of subjects included in these studies was insufficient to estimate the risk for rare severe reactions (i.e., encephalopathy or anaphylactic shock). Surveillance for these rare adverse events will be needed as acellular pertussis vaccines are used more widely.

Cherry, J.D (1988)., Brunell, P.A., Golden, G.S., Karzon, D.T., (1988), Report of the task force on pertussis and pertussis immunization, Pediatrics 81:6 Part 11 (June 1988) Supplement pp 936-984.

Extract: For more than 25 years, it has been known that pertussis vaccine is a reliable adjuvant for the production of experimental allergic encephalitis.74998 This experimental allergic encephalomyelitis is mediated by sensitized lymphocytes rather than serum antibody mechanisms.52 Pertussis vaccine has also been used as an adjuvant in the following experimental autoimmune diseases: thyroiditis, myocarditis, glomerulonephritis, uveoretinitis, and hemolytic anemia.499 Except for the adjuvant effect upon antibody responses to specific vaccines, there is no evidence that any of the experimental adjuvant activities of pertussis vaccine, and specifically LPF, occur in vaccinated children.

National Vaccine Injury Compensation Program Vaccine Injury Table http://www.hrsa.dhhs.gov/bhpr/vicp/table.htm#

 

Au-Jensen M, et al.    Is the acute encephalopathy test in mice suited for control of pertussis vaccines? Dev Biol Stand. 1985;61:447-51. PMID: 3835081; UI: 86221312.

 Animal models to control the serious neurological complications after vaccination against whooping cough are not available. In a recent paper pertussis vaccine induced acute encephalopathy in certain mouse strains (1). Healthy BALB/c mice died with shock-like symptoms after immunization with bovine serum albumin (BSA) and heat-killed pertussis. Mice not sensitized with BSA survived, and mice of strains with another H-2 type than H-2d were not susceptible. The authors concluded that the susceptibility to side effects to pertussis vaccine in mice and possibly in human is linked to the MHC. We tried to repeat the experiments reported by Steinman et al. in the hope that the murine encephalopathy model would be useful to evaluate possible neurological complications. In spite of having the same H-2d genotype, the BALB/c mice of two breeding stocks did not develop shock-like symptoms with fatal consequences after the last injection with BSA. This fact corresponds possibly with the author’s observation that the pertussis vaccine encephalopathy is not under the control of H-2 genes alone. As shown in our tests the sudden deaths and encephalopathy in mice are not linked to BSA-sensitization because mice who received pertussis vaccine only showed the same symptoms as mice injected with BSA and vaccine. Histology did not indicate brain damage. It seems obvious that the deaths in our experiments were caused by the pertussis toxins present in the large numbers of bacteria given.

 

DTP and DTaP vaccines are not the only vaccines that have raised red flags.

Early fears about MMR in secret papers (2007)

Crowley S, et al.  Mumps, measles, and rubella vaccination and encephalitis. Also note comment.

 

Measles-Mumps-Rubella (MMR) Vaccine as a Potential Cause of Encephalitis (Brain Inflammation) in Children—–Harold E. Buttram, MD

Bolukbasi O, et al.    Acute disseminated encephalomyelitis associated with tetanus vaccination. Eur Neurol. 1999;41(4):231-2. No abstract available.PMID: 10343155; UI: 99276501.   

Hemachudha T, et al. Myelin basic protein as an encephalitogen in encephalomyelitis and polyneuritis following rabies vaccination. N Engl J Med. 1987 Feb 12;316(7):369-74. PMID: 2433582; UI: 87115665.

 Polyneuritis cranialis? Brain stem encephalitis and myelitis following preventive influenza vaccination. Buchner H, et al.  1988 Nov;59(11):679-82.  German. No abstract available. PMID: 3211251; UI: 89097428   

Morphological changes in the central nervous system in post-vaccinal encephalomyelitis developing after chickenpox vaccination in children. Ravkina LI, et al. 1970; 70(10):1465-71. Russian. PMID: 4395233; UI: 71064831. 

 Acute disseminated encephalomyelitis and meningococcal A and C vaccine: case report.

A 25-year-old women developed acute disseminated post-vaccinal encephalomyelitis (ADEM) following vaccination with A plus C meningococcal vaccine (Pasteur-Merieux). Fast disappearance of symptoms and gradual resolution of MRI demyelinating lesions occurred after steroid treatment with high doses of intravenous methylprednisolone. To our knowledge, ADEM has not been previously described in association with meningococcal vaccine. Although most cases of ADEM occur following viral infections and vaccination, the syndrome has previously been related to leptospirosis and Mycoplasma pneumoniae infections. This suggests that it may also be related to exposure to polysaccharide-protein vaccines such as the Group A plus Group C meningococcal vaccine.

 

An Italian Study Finding Biochemical Markers of Vaccine Damage (1996)

Comment by Harris L. Coulter: This is, to my knowledge, the first investigation to find biochemical markers of vaccine damage. It has not yet been published but deserves publication. My translation omits the tables and part of the bibliography, but the text is complete. This study should also have an impact on HLA typing, since it shows that vaccinations can have an effect on the individual’s HLA type (i.e., that it is not necessarily congenital).

Resume
This study involves observations of 30 patients with post-vaccinal pathology of the central nervous system and other systems where the first symptoms appeared concomitantly with, or immediately after, administration of a vaccine. All patients were subjected to serologic testing for herpes virus (IgG and IgM) and to HLA (A, B, C) and HLA-DR-DQ tissue typing to see if there was any correlation between the emergence of CNS pathology and these various antigens, thus to show a possible autoimmune-type immunogenetic basis for demyelination processes. Statistical comparison with the Italian population used as controls revealed an increase in the HLA-A3 and HLA-DR7 antigens. The presence of A3 and/or DR-7 was observed in 22/30 (73.3%) of the patients.

…This allowed us to relate these data to specific clinical pictures — patients who had earlier been diagnosed with epilepsy, myoclonic epilepsy, evoving epilepsy, epileptigenic encephalopathy, autism, West Syndrome, and Angelman’s Syndrome. All the patients had presented with the first symptoms shortly after receiving the prophylactic vaccination or somewhat later.

The first symptoms were convulsions, very high fever, or diarrhoea immediately following a compulsory vaccination. The parents had told their physicians about this; then, after taking EEGs and visiting neuropsychiatric specialists or pediatricians without getting any satisfaction, the physicians had administered the recall shots of the vaccines leading very shortly to stabilization of the condition with progressive clinical deterioration.

These children were mostly from 3 to 9 months old. All patients were studied for the presence of metabolic diseases with negative results; then chromosomal mapping was done, also with negative results; encephalic TAC and RMN were performed at first appearance of the symptomatology, also with negative results.

Conclusion
All the patients observed presented various physical problems. The various types of CNS pathology could be due to a delatentization of preexisting autoimme damage by viral DNA. It has been observed that the “cleaner” the species, from the virologic or microbiologic point of view, the more likely it is to present autoimmune conditions of the CNS and other apparatuses. The results indicate that autoimmune pathology is more frequent in countries where vaccination is more widespread, i.e., in countries defined as “clean.” With this study, and with the individualization of alleles such as A3 and DR7, in the presence of viral DNA, it would be possible to define the subjects at risk of an autoimmune pathology from vaccination. The action of thimerosal used as an excipient in vaccines, and whose toxicity is independent of thedose administered, could demonstrate the possibility of changes in the aminoacids of the molecules which preserve the antigen.

Clinical suppression of experimental allergic encephalomyelitis by muramyl dipeptide “adjuvant”. Root-Bernstein RS, et al. Brain Res Bull. 1986 Oct; 17(4):473-6.  PMID: 3779448; UI: 87050859.

Abstract :Experimental allergic encephalomyelitis (EAE) is a model for several human diseases including multiple sclerosis and post-vaccinal encephalopathies. EAE is generally thought to be an autoimmune response to the antigen myelin basic protein (MBP). Oddly, MBP can also suppress EAE, and many observations suggest that an independent immune response to so-called “adjuvant” material is also necessary to EAE induction. Thus, EAE may be a result of a pair of interactive immune responses, one against MBP, and one against adjuvant. If so, the adjuvant should, like MBP, suppress EAE. We present data from experiments on strain 13 guinea pigs demonstrating EAE suppression by muramyl dipeptide, an active component of complete Freund’s adjuvant. These results are striking because classically adjuvants are defined as immunopotentiators, not immunosuppressants. Our results, therefore, suggest that a revaluation of the role of adjuvants in inducing autoimmune diseases may be necessary.

 

SICK MONKEYS: RESEARCH LINKS VACCINE LOAD, AUTISM SIGNS

The first research project to examine effects of the total vaccine load received by children in the 1990s has found autism-like signs and symptoms in infant monkeys vaccinated the same way. The study’s principal investigator, Laura Hewitson from the University of Pittsburgh, reports developmental delays, behavior problems and brain changes in macaque monkeys that mimic “certain neurological abnormalities of autism.”

 

 “…For every vaccination, minimal encephalopathy destroys brain cells. As a result, in Germany, there are 1.2 million children who have contracted hyperkinetic syndrome who are then treated with Psychopharmeca (a drug similar to Ritalin) used to calm them down… We have hundreds of thousands of so-called minimal cerebral dysfunction cases and millions of neurodermatitis patients. In Germany, there are millions of people with allergies. We don’t just produce minimal encephalopathies in the brain, but we also produce modifications of the genetic code.”–Dr Buchwald MD[Media Sept 2002] Bosnia halts using Unicef-donated DTP vaccines after baby contracts encephalitis

 

Workshop on Neurologic Complications of Pertussis and Pertussis Vaccination. Menkes, J.H (1990). and Kinsbourne, M., Neuropediatrics 21 (1990) 171-176.

 In evaluating side-reactions to the vaccine, the following must be kept in mind:

Vaccines are not standardized between manufacturers.

For a given manufacturer, vaccines are not standard from one batch to the next.

Unless the vaccine is properly prepared and refrigerated, its potency and reactivity varies with shelf life.

In fact, the whole question of vaccine detoxification has never been systematically investigated.

Listed in order of increasing severity, observed adverse reactions include irritability, persistent, unusually high-pitched crying, somnolence, seizures, a shock-like “hypotensive, hyporesponsive” state, and an encephalopathy. Since the neurologic picture is not specific for pertussis vaccination, its temporal relationship to the vaccination is the critical variable for determining causation.

Although the majority of seizures following pertussis vaccination are associated with fever, it was the consensus of the neurologists attending the workshop, that these do not represent febrile convulsions, but are non-benign convulsions.

The incidence of post-vaccine encephalopathy is difficult to ascertain. The most carefully conducted retrospective case-control study reported that the relative risk of a previously normal infant for the onset of an illness leading to encephalopathy with permanent subsequent disability was 4.2 time greater during the first 72 hours following DPT vaccination than in controls. From this study, the risk for permanent brain damage following DPT has been calculated as 1:310,000 doses. (my note – 1:310,000 doses translates to an actual risk of 1:62,000 – this figure is from the National Childhood Encephalopathy Study which excluded any child whose seizure lasted for less than 30 minutes and who was not hospitalised as a result of their seizure. )

 

There are hundreds of articles like these in the medical literature so you get the picture.

 

Encephalitis Redefined. Why?

“Under the 1986 law, DHHS was supposed to produce information brochures describing each vaccine’s benefits and risks so doctors could educate parents before vaccination of their children took place.  We worked for several years with DHHS on these brochures but DHHS eventually got an amendment to the law to reduce the brochures to a one page information sheet that does not contain enough information to adequately inform parents about vaccine risks or how to monitor their child following vaccination for signs that a reaction is occurring………Today, the bitter truth is that, although more than one billion dollars has been paid out to some 1,000 families whose loved ones have been harmed by vaccines, three out of four vaccine victims are turned away……….And to make it easier for compensation to be denied to vaccine injured children, under rule making authority these federal agencies gutted the Table of Compensable Events in 1995 and arbitrarily rewrote the definition of encephalopathy (brain dysfunction) that had been used by medicine decades……   We tried to stop the destruction of the Table of Compensable Events by bringing suit in federal court, but we lost. So, today, almost no cases of brain damage following DPT vaccination are presumed to be caused by the vaccine. The vaccine injury compensation program has been turned into the trial we were promised it would not be, where causation in fact must be proven in almost every case and vaccine victims and their lawyers are left begging for compensation from federal health agencies holding all the cards. The federal compensation system that we were told would be “simple justice for children,” has become a cruel joke, a sad commentary on a national health policy that forces children to take the risk and then leaves many families to cope with the catastrophic consequences on their own when the risk turns out to be 100 percent.”–Barbara Loe Fisher   Also: National Vaccine Injury Compensation Program (VICP)

“Encephalopathy was redefined so that the diagnosis requires as a sine qua non in excess of 24 hours of a diminished level of consciousness, a criterion which is far more restrictive than that of the leading epidemiological study of pertussis vaccine injury, the British National Childhood Encephalopathy Study (NCES). Moreover, seizures have been removed from the Table, although that the pertussis vaccine can cause seizures is uncontested (and warned in the manufacturer’s package insert).”–Marcel Kingsbourne

 

Somewhat 35 years ago, when I worked in Gamaleya Institute of Epidemiology and Microbiology, a leading Russian center for vaccines development and immunology research, a tragedy happened: our measles vaccine caused an epidemics of encephalitis among vaccinated. Our senior immunologist and virologist, prof. Svet-Moldavsky, was sent to investigate. It turned out that at producing facility they slightly modified protocol, using overgrown rats instead of very young, as was required. Live virus vaccines are made nowadays essentially as in days of Pasteur, by multiple passage on animals brains. So these vaccines can induce antibody production not only to virus antigenes, but to components of brain tissue as well. While antigene composition of human and animals tissues is different, some overlapping exists, so autoimmune response against brain tissue of vaccinated children is possible. This happened in this case. The story never leaked into press, of course, due to Soviet era secrecy, but everybody in Institute knew it.
    

Measles lethality drastically plummeted in last few decades, from several procents to one case in thousand infected. Most of it was due to concurrent bacterial infection pneumonia, which now effectively treated by antibiotics; these 1/1000 deaths are also caused not by virus itself, but autoimmune reaction on this virus targeting brain tissue. But there are sound reasons to fear that attenuated vaccine virus can induce analogic reactions. Many parents reported onset of autism symptoms immediately (several hours after) vaccination. Too early for viremia, but timing is exact for autoimmune reaction. The Wakefield witch-hunt–Melanie Phillips

 

…Encephalitis (whether from vaccination or from some other cause) can range from severe to moderate, even subclinical. It is also possible to have encephalitis in which the acute symptoms are extremely mild but which still does much long-term damage. The “less serious” long-term sequelae resemble the more severe cases but are milder. Instead of having epilepsy or seizures, the children suffer from what are called “staring spells” or “absence seizures.” Instead of being mentally retarded to the point of incapacity to function in society, they suffer loss of IQ: many function at the 80 or 90 IQ level — just above subnormality. Instead of paralysis or cerebral palsy, they may lose a degree of muscular control — “atony” — especially of the hands. The parents will say that the baby doesn’t use his hands for crawling, or that he picks up objects with his feet instead of his hands. They manifest all the cranial nerve palsies, but in a less severe form. Instead of being blind, they have astigmatisms and nystagmus (involuntary and jerky repetitive movements of the eyeballs). They can be cross-eyed. They may have trouble moving their eyes from side to side. Or they are dyslexic, cannot read letters, cannot spell, cannot understand numbers, and the like. A peculiar feature is that they sometimes have obsessions about people’s eyes, are afraid to look others in the eyes, etc.. Instead of being totally deaf, they have mild loss of hearing. Or they have chronic earaches — otitis media…

 Another long-term effect of this vaccine is tendency to allergies, especially allergy to milk. Needless to say, a large proportion of the population in all of the industrialized countries of the world today suffer from allergies. We found that newborn infants with colic — meaning an allergy to milk– tend to react more strongly to the vaccine. Undoubtedly colic should be considered a counter indication to vaccination.

Another long-term effect is disturbance of sleep rhythm; the child turns night into day and day into night. They are often hyperactive. They have an extremely short attention span. Their behavior is dominated by impulses. They have lowered resistance to infection — due, presumably, to defective operation of the immune system. Other serious disorders are: seizures and epilepsy, blindness or loss of speech, paralysis or palsy of one or several limbs, and mental retardation. These are all possible effects of the vaccine. So one finds the same kinds of physical disabilities as in the more profoundly affected children, but everything is somewhat milder. “Mild” here is a relative term. After all, hyperactivity, dyslexia, and short attention span are very serious social problems — leading, in fact, to the collapse of the American educational system today. Indeed, the physical disabilities are only part of the picture. Harris L. Coulter, Ph.D. Vaccination Social Violence and Criminality.

 

To be continued…

Elderberry is an Effective Treatment for Colds and Flu

Elderberry is an Effective Treatment for Colds and Flu

…Elderberry is primarily recognized as providing natural support for the immune system. Elderberry contains concentrated amounts of vitamin C, flavinoids, fruit acids, and anthocyanic pigments. It is also an excellent source for vitamins A and B and may also have antiviral properties.

…There is new evidence concluding that Elderberries have great value in fighting flu and other similar viruses. Elderberry has an ability to help break fevers because it promotes profuse sweating.

The list of attributes that Elderberry boasts is impressive. Elderberry works as a simple cleanser and also as an antioxidant. It is also a diuretic, an anti-inflammatory, an anti-catarrhal, and can act as a mild laxative. This useful herb can be used for bronchitis, catarrh, coughs, sore throats, fevers, influenza, neuralgia, rheumatism, sciatica, skin disorders, and even hay fever.

Elderberry’s use as a flu remedy dates back to ancient Roman times. Typically, Elderberry consumption will improve flu symptoms within three days. Elderberry has been proven effective against eight different strains of influenza. This fact alone gives it a stronger record than any synthetic vaccine being offered at a clinic this winter. In addition, laboratory studies on Elderberry concerning HIV, herpes, and Epstein-Barr viruses have all had positive results.

To effectively utilize Elderberry, make a tea with 3 to 5 grams of the dried flowers steeped in 1 cup of boiling water for 10 to 15 minutes. This may be taken three times a day. Liquid Elderberry extract can be taken twice a day. The dosages are 5 ml (for children) and 10 ml (for adults). Between 20 and 60 drops of a tincture may be taken two or three times a day.

One caution – the leaves and stems of Elderberry are considered slightly toxic if they are ingested in raw form. There are no other known adverse reactions, however. There is also no evidence of other drug interactions with Elderberry.

Full Article

Doctors rethink costly vaccines

Doctors rethink costly vaccines

About one in 10 doctors who vaccinate privately insured children are considering dropping that service largely because they are losing money when they do it, according to a new survey.

A second survey revealed startling differences between what doctors pay for vaccines and what private health insurers reimburse: For example, one in 10 doctors lost money on one recommended infant vaccine, but others made almost $40 per dose on the same shot.

…The studies did not look at the 50 percent or more of vaccinations paid for by government, which generally provides free vaccines to doctors and covers administrative fees.

Full Article

Let me get this straight…the government pays for 50% + of the vaccines and administration costs given to doctors for free. Yet one vaccine they buy, and loose a few bucks on, is a problem? Am I missing something?Seriously, are you kidding me?!?!

This ‘money thing ‘ is exactly why parents are having problems finding Ped’s when they choose to delay/select or refuse all vaccines. It has never been about the best interests of your child. It’s always been about the money! So what do they want? A bailout too?

 

Sanofi Pasteur Wants Liability Protection for Vaccinating Pregnant Women

Sanofi Pasteur Wants Liability Protection for Vaccinating Pregnant Women

By Kelli Ann Davis

Today, during the Institute of Medicine’s (IOM) 2nd National Stakeholder Meeting on the Review of Priorities in the National Vaccine Plan, Stanley Plotkin, Executive Advisor to the CEO of Sanofi Pasteur and Emeritus Professor of Pediatrics at the University of Pennsylvania made a startling revelation: Sanofi Pasteur is lobbying members of the Senate for liability protection.

According to Plotkin, Sanofi Pasteur is concerned about the “legal issue of vaccinating while pregnant” and feels it is “important to keep non-negligence issues” out of the tort system; he stated, “it needs to be addressed” and then went on to say, “I don’t know how it should be done but it needs to be addressed considering what’s happening recently.”

Continued

Exemptions

vaccinexemption

To be continued…discussion, articles, references and more!

Gardasil trials update–“New Medical Conditions”

Gardasil trials update–“New Medical Conditions”

By Cynthia A. Janak

…I found an interesting document on the FDA website about my favorite topic, Gardasil.

Subject: Clinical Review of Biologics License Application Supplement for Human Papillomavirus Quadrivalent (Types 6, 11, 16, 18) Vaccine, Recombinant (Gardasil®) to extend indication for prevention of vaginal and vulvar cancers related to HPV types 16 and 18.

Dated September 11, 2008

http://www.fda.gov/cber/products/gardasil/gardasil091108.pdf

This document is 187 pages long and I was scanning this document for adverse events. I did find something interesting starting on their page 132; it was Table 73, titled “New Medical Conditions” Days 1–15…

The total study participants were 5088 for Gardasil and 3790 for the Placebo. (Now let us remember that this group includes the Alum and carrier solution placebos.) The participants that they were able to follow-up with were 5012 for Gardasil and 3725 for the Placebo group.

What caught my eye with this table was the fact that these participants did not have these conditions prior to the study. I surmise this because of the title “New Medical Conditions”. So in essence these individuals were probably healthy average people with active lives and families.

Here is what I found.

Continued

Gardasil trials update–“New Medical Conditions”

Gardasil trials update–“New Medical Conditions”

Deirdre Imus: How Do I Find a Green Pediatrician?

Deirdre Imus: How Do I Find a Green Pediatrician?

…Today I found a great link at Deirdre Imus’ website to the “Integrative Pediatrics Council” HERE which provides a list of “green” pediatricians throughout America (and one in Canada.)

The Pentagon — A Voice of Reason on Vaccines and Autism?

The Pentagon — A Voice of Reason on Vaccines and Autism?

David Kirby

Recently, several documents have been brought to my attention which, when viewed together, suggest that the Department of Defense has legitimate concerns about vaccine injuries and their possible connection to autism, perhaps more so than other branches of the Federal Government.

These documents raise several questions that I am currently trying to get answered from DOD officials:

1) Autism may be an “adverse event” of Tripedia (DTaP) use

According to the website of the Vaccine Healthcare Centers Network, run by DOD and CDC, autism is listed as an “adverse event” associated with use of the Tripedia triple vaccine for diphtheria, tetanus and pertussis.

My questions are: Why does autism appear here? Does VHC consider autism to be a possible adverse event of DTaP use, or has it simply been reported that way by parents?

2) Patients who have bad vaccine reactions should avoid multiple vaccines in the future

According to this VHC slide, any patient who has a “Systemic Event” following immunization – defined as “symptoms and signs of illness after vaccination” and “any reaction that does not involve the injection site” – should avoid multiple vaccines in the future, if possible.

My questions are: Is that standard DOD policy? Is there an alternative schedule for these patients? Does this advice apply to children of service members as well? Why is this information not shared with civilian doctors and pediatricians?

3) Patients who develop serious neurological diseases might need vaccine exemptions in the future

This VHC slide says that a patient who develops a severe neurologic disease following vaccination might need temporary or permanent exemption from future vaccines. Such diseases include peripheral neuropathy, encephalopathy (including autism, presumably) Guillain-Barré syndrome and progressive focal neurologic disease. Such patients should be given temporary exemptions from future vaccinations.

Meanwhile, risks for recurrent reactions should be assessed before additional doses are given, and “permanent vaccine exemption may be required.”

Again, is this DOD policy? Are such exemptions given? Because autism is listed as a “severe neurological disease,” would those patients (ie, children of service members) also be exempt from future vaccinations? And, on a related note, does VHC consider autism to be a “neurological disease,” as opposed to a developmental/behavioral disorder?

4) Mercury, and possibly thimerosal may cause autism and dementia

According this slide (#22) on the vaccine preservative thimerosal, from the Armed Forces Institute of Pathology (AFIP), “exposure to mercury in utero and children may cause mild to severe mental retardation and mild to severe motor coordination impairment.” The slide also seems to indicate that autism and dementia might questionably be “health effects” of mercury or thimerosal exposure.

My question is: Why does autism appear on a list of health effects on a slide about thimerosal, even if it is followed by a question mark?

5) Alternative biomedical treatments may be prescribed for thimerosal exposure

The same slide says that “treatments” for thimerosal exposure include: “Methyl-B12, ointment DMPS, & glutathione (GSH).” These are all alternative (some would say fringe, radical and dangerous) treatments being used today by thousands of autism parents and their children’s physicians, with varying degrees of success (including reports of full recovery).

Methyl-B12 – has been shown to repair damage to the process of methylation, and to restore methionine and glutathione levels in patients with autism to within normal ranges.

DMPS – is a sulfur-based amino acid used in the process of chelation – in which sulfur molecules bind with heavy metals such as mercury, and eliminate them from the system.

Glutathione – is a sulfur-based protein that binds with heavy metals and eliminates them from the system. It is also a powerful anti-oxidant. Many children with autism show signs of glutathione depletion, heavy metal accumulation and oxidative stress.

My questions are: Was the speaker simply refering to treatments that some people have tried, or is the AFID endorsing these treatments for thimerosal toxicity and/or autism? On what evidence is this based? Are Methyl B-12 and GSH, like chelation, considered standard of care in the military for mercury toxicity? Can you explain why autism families in the military have these treatments covered, (at thousands of dollars a year), even if they also have an autism diagnosis? Is this why military insurance will pay for visits to doctors in the Defeat Autism Now network, which advocates the use of these non-traditional treatments?

I eagerly await the replies from VHC and AFID officials, and will update this blog as soon as I hear anything.

Meanwhile, regardless of the Pentagon’s positions on the above questions, we know for certain that DOD is concerned about the risk of injury from multiple vaccines.

In fact, it may even need to reconsider the practice.

“We have preliminary findings from one of our many on-going research studies that suggest a relationship between adverse events and multiple vaccinations exist,” US Army Colonel Renata J. M. Engler, MD, director of the VHC, (a “collaborative network” of the Defense Department and the CDC), wrote to Rep. Carolyn Maloney (D-NY). “These findings will require validation, but heighten our concern for the current clinical practice of multiple vaccinations.”

“The more drugs one is exposed to, the greater the likelihood of having an adverse event so as vaccine numbers increase, and (sic) we will see more people who have efficacy or safety issues,” Col. Engler said. “The standard of care (ie, in the context of mixing vaccines) is to minimize drug exposures because of the recognition that the more drugs being used, the greater the chance of a reaction and potentially a serious adverse event.”

I wonder when the CDC and America’s pediatricians will issue an equally thoughtful and cautionary statement, instead of their usual reassurance that small children can easily get 100,000 shots at once, without a single “serious adverse event” among them.

*update:

Age of Autism

VHCN  _the page that is now under revision you can view here.

Toy Warning

Some Products on Shelves this Holiday Season Will be Illegal to Sell in February

One in Three Children’s Toys Tested by http://www.healthytoys.org/ Found to have Significant Levels of Toxic Chemicals Including Lead, Flame Retardants, and Arsenic.

Lead was detected in 20% of the toys tested this year.  In fact, lead levels in some of the products were well above the 600 parts-per-million (ppm) federal recall standard used for lead paint, and will exceed the U.S. legal limit in February, according to the new Consumer Product Safety Commission (CPSC) regulations.  Levels of lead in many toys were significantly above the American Academy of Pediatrics recommended ceiling of 40 ppm of lead in children’s products.  Children’s jewelry remains the most contaminated product category, maintaining its spot at the top of HealthyToys.org’s “worst” list.

The CPSC regulations, which go into effect in February 2009, would make certain products on the shelf this holiday season illegal to sell two months from now.  Experts insist that these new regulations, while a good first step, do not go nearly far enough to protect our children.

“There is simply no place for toxic chemicals in children’s toys,” said Ecology Center’s Jeff Gearhart, who led the research. “Our hope is that by empowering consumers with this information, manufacturers and lawmakers will feel the pressure to start phasing out the most harmful substances immediately, and to change the nation’s laws to protect children from highly toxic chemicals.”

In addition to allowing parents to search by product name, brand, or toy type to see if certain toys have toxic chemicals, the newly-redesigned site also allows visitors to create a personalized holiday wish list that can be sent to family and friends, and a blog-friendly widget to quickly search the toy ratings.

Researchers tested for chemicals that have been associated with reproductive problems, developmental and learning disabilities, hormone problems and cancer; and for those that have been identified by regulatory agencies as problematic.  Babies and young children are the most vulnerable populations because their brains and bodies are still developing, and because they frequently put toys into their mouths.  The testing was conducted with a screening technology – the portable X-Ray Fluorescence (XRF) analyzer – that identifies the elemental composition of materials on or near the surface of products.

Highlights from the HealthyToys.org 2008 findings:

  • Lead is Still in Toys – HealthyToys.org found lead in 20% of all the products tested this year, including 54 products (3.5%) that exceed the current 600 ppm recall threshold for lead-based paint, and the soon-to-be national standard for all children’s products.  When children are exposed to lead, the developmental and nervous system consequences can be irreversible.  The American Academy of Pediatrics has recommended a level of 40 parts per million (ppm) of lead as the maximum that should be allowed in children’s products.
  • It’s Not Just China – HealthyToys.org has not found a consistent correlation between the country of manufacture and the presence of toxic chemicals in toys.  21% of toys from China and 16% of those from all other countries had detectable levels of lead in 2008.  17 toys manufactured in the U.S. were sampled and 35% of those had detectable levels of lead.  Two toys had levels above 600 ppm.  Among the highest lead levels detected in HealthyToys.org (190,943 ppm) was in a Halloween Pumpkin Pin made in the USA.
  • It’s Not Just Lead – HealthyToys.org found a significant number of toys containing cadmium, mercury, arsenic, and bromine.  2.9% (45 products) had bromine at concentrations of 1,000 ppm or higher.  This indicates the likely use of brominated flame retardants — chemicals that may pose hazards to children’s health.  Other toxic chemicals found in toys include arsenic, cadmium, and mercury.  Arsenic was detected at levels greater than 100 ppm in 22 or 1.4% of products; 289 (18.9%) of products contained detectable levels of arsenic.  Cadmium was found above 100ppm in 30 (1.9%) of products; 38 (2.4%) of products contained detectable levels of cadmium.  Mercury was found above 100 ppm in 14 (1%) of products; 62 (4.2%) of products contained detectable levels of mercury. 
  • Polyvinyl Chloride (PVC / Vinyl) – HealthyToys.org identified products made with PVC plastic by measuring their chlorine content.  PVC is a problematic plastic because it creates major environmental health hazards in its manufacture and disposal and may contain additives, including phthalates, that may pose hazards.  27% of toys (excluding jewelry) tested this year by HealthyToys.org were made with PVC.
  • Jewelry – Jewelry remains the most contaminated product category tested.  Children’s jewelry is five-times more likely to contain lead above 600 ppm than other products.  15% of jewelry samples (compared to 3% of other products) had lead levels above 600 ppm.  Overall, jewelry is twice as likely to contain detectable levels of lead as other products.  Numerous Hannah Montana brand jewelry items tested high for lead.  HealthyToys.org recommends that consumers avoid low cost children’s jewelry.
  • The Good News – The good news is that 62% (954) of the products tested contain LOW levels of chemicals of concern, and 21% (324) of all products contain NO chemicals of concern.  These products look and feel no different than other children’s products on the shelf.  These findings show that manufacturers can and should make toys free of unnecessary toxic chemicals.

Encephalitis and Encephalopathy (part 1)

Encephalitis

headVaccines containing Pertussis and Measles can cause encephalitis. Per the VICP guidelines; onset of encephalitis from Pertussis-containing vaccines is 24-48 hours, and between day five and fifteen for the MMR, M, MR and R vaccines.  
 
 
This is what the Vaccine Injury Compensation Program stated in the late 1980’s: 
 
The neurologic signs and symptoms of encephalopathy may be temporary with complete recovery or may result in various degrees of permanent impairment.  
 
Signs and symptoms such as high-pitched and unusual screaming, persistent inconsolable crying, and bulging fontanel are compatible with an encephalopathy, but in and of themselves are not conclusive evidence of encephalopathy. Encephalopathy usually can be documented by slow wave activity on an electroencephalogram. 
 
Today it states: 
 
The following clinical features alone, or in combination, do not demonstrate an acute encephalopathy or a significant change in either mental status or level of consciousness as described above: Sleepiness, irritability (fussiness), high-pitched and unusual screaming, persistent inconsolable crying, and bulging fontanelle. Seizures in themselves are not sufficient to constitute a diagnosis of encephalopathy. In the absence of other evidence of an acute encephalopathy, seizures shall not be viewed as the first symptom or manifestation of the onset of an acute encephalopathy.  

 

 

*This means it is no longer considered a contradiction to further vaccination.
 

An adverse reaction association does have a name and it is called: Crying Syndrome or Screaming Syndrome.  The scream is also known as cry-encephalitis. The cause is infection of the brain from the vaccine virus/bacteria. When the body is injected with virus/bacteria it can travel to the brain and cause encephalitis. Encephalitis can be a reaction to any vaccine but the DTP and DTaP is the most common.
 

What is interesting to note is that when encephalitis occurs following an illness, a doctor will treat it correctly. However, following a vaccination, a doctor will tell you it is a normal reaction to the vaccine and do nothing.

 

Workshop on neurologic complications of pertussis and pertussis vaccination
  

A multidisciplinary workshop held from September 29 to October 1, 1989, at Airlie House, Warrenton, Virginia, considered the neurologic complications of whooping cough and pertussis vaccine. Pertussis mortality in the U.S. in 2-3/1000 cases. Seizures occur in 1.9% of cases, and encephalopathy in 0.3%. Reviewing all data, it appears likely that a combination of one or more bacterial toxins, asphyxia, CO2 retention and loss of cerebral vascular autoregulation is responsible for neurologic symptoms. The timing of the encephalopathy suggests that it results from increased lysis of bacteria, and release of endotoxin. The encephalopathy is not confined to the paroxysmal phase. In evaluating side-reactions to the vaccine, the following must be kept in mind: 1. Vaccines are not standardized between manufacturers. 2. For a given manufacturer, vaccines are not standard from one batch to the next. 3. Unless the vaccine is properly prepared and refrigerated, its potency and reactivity varies with shelf life. In fact, the whole question of vaccine detoxification has never been systematically investigated. Listed in order of increasing severity, observed adverse reactions include irritability, persistent, unusually high pitched crying, somnolence, seizures, a shock-like “hypotensive, hyporesponsive” state, and an encephalopathy. Since the neurologic picture is not specific for pertussis vaccination, its temporal relationship to the vaccination is the critical variable for determining causation. Although the majority of seizures following pertussis vaccination are associated with fever, it was the consensus of the neurologists attending the workshop, that these do not represent febrile convulsions, but are non-benign convulsions. The incidence of post-vaccine encephalopathy is difficult to ascertain.

 

 Basically, the screaming is caused by the pain of the endotoxin in the vaccine getting into his brain. The screaming then causes a release of cortisol through the body which disrupts the immune system. It also causes the body temperature to rise. The intestines ph or acidity of changes, and bacteria called e-coli increases. If the amount gets high, that is when it can cause problems. The DTP is known to slow the function of the liver but it is not known which babies will be affected. Therefore, it becomes important to neutralize the curlin and take strain off the liver.

 

According to Drugs.com:

 

Diphtheria / Tetanus Toxoids / Acellular Pertussis Vaccine

( DTaP/Tdap ) Pronouncation: (diff-THEER-ee-uh/TET-ah-nus/ay-SELL-yoo-ler per-TUSS-uss vaccine) Class: Toxoid

 

Trade Names: 
Adacel(Tdap)

Active booster immunization against diphtheria, tetanus, and pertussis as a single dose in persons 11 to 64 yr of age.
– Injection 2 Lf units diphtheria toxoid, 5 Lf units tetanus toxoid, 3 mcg pertactin, 5 mcg filamentous hemagglutinin (FHA), 2.5 mcg detoxified pertussis toxins, 5 mcg fimbriae types 2 and 3 per mL.

 
Boostrix(Tdap)

Active booster immunization against diphtheria, tetanus, and pertussis as a single dose in persons 10 to 18 yr of age.
– Injection 2.5 Lf units diphtheria toxoid, 5 Lf units tetanus toxoid, 2.5 mcg pertactin, 8 mcg FHA, 8 mcg inactivated pertussis toxins per 0.5 mL
Daptacel
– Injection 15 Lf units diphtheria toxoid, 5 Lf units tetanus toxoid, 10 mcg pertussis toxoid, 5 mcg FHA, 3 mcg pertactin, 5 mcg fimbriae types 2 and 3 per 0.5 mL

 

Infanrix
– Injection 25 Lf units diphtheria, 10 Lf units tetanus toxoid, 25 mcg pertussis toxin, 25 mcg FHA, 8 mcg pertactin per 0.5 mL

 

Tripedia
– Injection 6.7 Lf units diphtheria toxoid, 5 Lf units tetanus toxoid, 46.8 mcg pertussis antigens (approximately 23.4 mcg each of inactivated pertussis toxin and FHA) per 0.5 mL

Daptacel , Infanrix , Tripedia (DTaP)

Active immunization against diphtheria, tetanus, and pertussis in infants and children 6 wk to 6 yr of age (prior to seventh birthday).

 

Per CDC, Tdap is for use in adults and children 10 yr of age and older, and DTaP is for use in infants and children younger than 7 yr of age.

Contraindications

Encephalopathy within 7 days of previous administration of DTP, Tdap, or DTaP that is not attributable to another cause; progressive neurologic disorders (eg, infantile spasms, uncontrolled epilepsy, progressive encephalopathy), in addition, pertussis vaccine should not be administered to persons with these conditions until a treatment regimen has been established and condition has stabilized; hypersensitivity to any component of the vaccine; history of serious allergic reaction temporarily associated with a previous dose of vaccine or any component of the vaccine.

 

Daptacel , Infanrix , Tripedia

Use in adults or children 7 yr of age and older; if contraindication to pertussis vaccine component occurs, substitute diphtheria and tetanus toxoids for pediatric use (DT) for each remaining dose; defer elective immunization procedures during outbreak of poliomyelitis because of risk of provoking paralysis.

 

It is recommended that the same brand of DTaP ( Daptacel , Infanrix , Tripedia ) be given for all doses in the immunization series because no data exist on the interchangeability of DTaP vaccines. Tdap vaccines ( Adacel , Boostrix ) are not interchangeable with DTaP vaccines.

 

 

Anticoagulants

Give DTaP/Tdap with caution to patients on anticoagulant therapy.

 

Immunosuppressants

May reduce vaccine’s efficacy.

 Influenza vaccine

To attribute causality of adverse reactions, do not give influenza vaccine within 3 days of pertussis vaccination.

Laboratory Test Interactions

None well documented.

 

Adverse Reactions

Cardiovascular

Boostrix

Myocarditis (postmarketing).

Daptacel

Cyanosis (postmarketing).

Infanrix

Cyanosis (postmarketing).

CNS

Adacel

Headache (44%); tiredness (30%); hyposthesia, paresthesia, vasovagal syncope (postmarketing).

 

Boostrix

Headache (43%); fatigue (37%); convulsion, encephalitis, facial palsy, paresthesia (postmarketing).

 

Daptacel

Fussines (76%); fretfulness (40%); drowsiness (33%); anorexia (11%); convulsions, febrile convulsion, grand mal convulsion, hypotonia, hypotonic-hyporesponsive episode, partial seizures, somnolence, screaming (postmarketing).

 

Infanrix

Drowsiness (38%); anorexia (12%); fussiness (9%); convulsions, crying, encephalopathy, hypotonia, hypotonic-hyporesponsive episode, irritability, somnolence (postmarketing).

 

Tripedia

Drowsiness (29%); irritability (25%); anorexia (10%); fussiness (6%); autism, convulsion, encephalopathy, grand mal convulsion, hypotonia, neuropathy, somnolence (postmarketing).

Dermatologic

Adacel

Rash (3%); pruritus, urticaria (postmarketing).

 

Boostrix

Exanthem, Henoch-Schonlein purpura, rash (postmarketing).

 Infanrix

Erythema, pruritus, rash, urticaria (postmarketing).

GI

Adacel

Nausea (13%); diarrhea (10%); vomiting (5%).

 Boostrix

GI symptoms including abdominal pain, diarrhea, nausea, vomiting (26%).

 Daptacel

Vomiting (7%); diarrhea, nausea (postmarketing).

 Infanrix

Vomiting (7%); diarrhea, intussusception (postmarketing).

 Tripedia

Vomiting (5%).

Hematologic-Lymphatic

Adacel

Lymph node swelling (7%).

 

Boostrix

Lymphadenitis, lymphadenopathy (postmarketing).

 

Infanrix

Idiopathic thrombocytopenic purpura, lymphadenopathy, thrombocytopenia (postmarketing).

 

Tripedia

Idiopathic thrombocytopenic purpura (postmarketing).

Hypersensitivity

Boostrix

Anaphylactic reaction, arthus-type hypersensitivity.

 

Daptacel

Allergic reaction, anaphylactic reaction (edema, face edema, face swelling, generalized rash and other types of rash, pruritus), hypersensitivity (postmarketing).

 

Infanrix

Anaphylactic reaction, hypersensitivity (postmarketing).

 

Tripedia

Anaphylactic reaction (postmarketing).

Local

Adacel

Pain (78%); erythema (25%); swelling (21%); injection-site bruising, sterile abscess

(postmarketing).

 

Boostrix

Pain (75%); redness (48%); swelling (39%); increase in arm circumference (28%); induration, inflammation, local reaction, mass, nodule, warmth (postmarketing).

 

Daptacel

Tenderness (50%); increased arm circumference (30%); redness (17%); swelling (12%); cellulitis, injection-site abscess, injection-site mass, injection-site nodule, injection-site pain, injection-site rash.

 

Infanrix

Redness (59%); swelling (50%); pain (27%); injection-site reactions (postmarketing).

 

Tripedia

Redness (33%); swelling (28%); pain (21%).

Musculoskeletal

Adacel

Body ache or muscle weakness (30%); sore and swollen joints (11%); muscle spasms, myelitis, myositis (postmarketing).

 

Boostrix

Arthralgia, back pain, myalgia (postmarketing).

 

Infanrix

Limb swelling (postmarketing).

Miscellaneous

Adacel

Chills (15%); fever (5%).

 

Boostrix

Fever (14%); insulin-dependent diabetes mellitus (postmarketing).

 

Daptacel

Crying (59%); decreased activity (51%); fever (24%).

 

Infanrix

Fever (7%); cellulitis, ear pain, respiratory tract infection, sudden infant death syndrome (postmarketing).

 

Tripedia

Fever (25%); apnea, sudden infant death syndrome (postmarketing).

 

Pregnancy

Category C .

Lactation

Undetermined.

Children

Adacel

Safety and efficacy not established in children younger than 11 yr of age.

 Boostrix

Not indicated for use in patients younger than 10 yr of age or older than 18 yr of age.

 

Daptacel , Infanrix , Tripedia

Safety and efficacy in infants younger than 6 wk of age not established; contraindicated for persons 7 yr of age and older.

Elderly

Adacel

Safety and efficacy not established in individuals 65 yr of age and older.

Special Risk Patients

If any of the following occurs in temporal relation with receipt of either whole-cell pertussis DTP or DTaP, carefully consider decision to administer subsequent doses of vaccine containing pertussis component: temperature of at least 105°F within 48 h not caused by another identifiable cause; collapse or shock-like state (hypotonic-hyporesponsive episode) within 48 h; persistent inconsolable crying lasting at least 3 h occurring within 48 h; or convulsions, with or without fever, occurring within 3 days. If the decision is made to withhold pertussis component, continue immunization with DT (Td if 7 yr of age and older). If Guillain-Barré syndrome occurs within 6 wk of receipt of prior vaccine containing tetanus toxoids, base decision to give subsequent doses of DTaP or any vaccine containing tetanus toxoids on potential benefits versus risks. Patients who experience serious Arthus-type hypersensitivity reactions following a prior dose of tetanus toxoids usually have high serum tetanus antitoxin levels and should not be given Td or DTaP vaccines or even emergency doses of Td more frequently than every 10 yr, even if wound is neither clean nor minor.

Bleeding disorders

Use with caution in patients with bleeding disorders (eg, thrombocytopenia, hemophilia) or receiving anticoagulant therapy.

Convulsions/CNS disorders

Family history of seizures or other CNS disorders is not a contraindication to pertussis vaccine.

Febrile illness or acute infection

Defer immunization during course of illness. Minor respiratory illness, such as mild upper respiratory tract infection, is usually not a reason to defer immunization.

Immunodeficiency

May have diminished antibody response; defer immunization, if possible, until immunocompetency is restored.

Latex sensitivity

Stoppers for Daptacel and Tripedia vials, and tip cap and rubber plunger of Infanrix and Boostrix needleless prefilled syringes contain dry natural latex rubber that may cause allergic reactions in latex-sensitive individuals.

 

Measles, Mumps, and Rubella (MMR) vaccine

Brand Names: M-M-R II

 

What should I discuss with my healthcare provider before receiving this vaccine?

You should not receive this vaccine if you are allergic to:

  • eggs;
  • gelatin;
  • neomycin (Mycifradin, Neo-Fradin, Neo-Tab); or
  • if you have ever had a life-threatening allergic reaction to any vaccine containing measles, mumps, or rubella.
  •  

You should also not receive this vaccine if you have:

  • a chronic disease such as asthma or other breathing disorder, diabetes, kidney disease, or blood cell disorders such as anemia;
  • severe immune suppression caused by disease (such as cancer, HIV, or AIDS), or by receiving certain medicines such as steroids, chemotherapy or radiation; or
  • if you are pregnant.
  •  

Before receiving this vaccine, tell the doctor if you have:

  • thrombocytopenia purpura (easy bruising or bleeding);
  • active tuberculosis infection;
  • a history of seizures;
  • a neurologic disorder or disease affecting the brain (or if this was a reaction to a previous vaccine);
  • a weak immune system caused by disease, bone marrow transplant, or by using certain medicines or receiving cancer treatments;
  • if you have received an immune globulin or other blood product within the past year; or
  • if you have received a previous MMR vaccine within the past 28 days (4 weeks).
  •  

You can still receive a vaccine if you have a cold or fever. In the case of a more severe illness with a fever or any type of infection, wait until you get better before receiving this vaccine.

You should not receive a measles, mumps, and rubella vaccine if you are pregnant. Wait until after your child is born to receive the vaccine.

Avoid becoming pregnant for at least 3 months after receiving a measles, mumps, and rubella vaccine.

Do no not receive this vaccine without telling your doctor if you are breast-feeding a baby.

What should I avoid before or after receiving this vaccine?

Do not receive another “live” vaccine such as oral polio, yellow fever, or varicella (chickenpox) for at least 4 weeks after you have received the measles, mumps, and rubella vaccine. The other live vaccine may not work as well during this time, and may not fully protect you from disease.

Measles, mumps, and rubella vaccines side effects

You should not receive a booster vaccine if you had a life-threatening allergic reaction after the first shot. Keep track of any and all side effects you have after receiving this vaccine. When you receive a booster dose, you will need to tell the doctor if the previous shots caused any side effects.

Becoming infected with measles, mumps, or rubella is much more dangerous to your health than receiving the vaccine to protect against these diseases. Like any medicine, this vaccine can cause side effects, but the risk of serious side effects is extremely low.

 

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • problems with hearing or vision;
  • extreme drowsiness, fainting;
  • easy bruising or bleeding, unusual weakness;
  • seizure (black-out or convulsions); or
  • high fever (within a few hours or a few days after the vaccine).
  •  

Less serious side effects include:

  • redness, pain, swelling, or a lump where the shot was given;
  • headache, dizziness;
  • low fever;
  • joint or muscle pain; or
  • nausea, vomiting, diarrhea.
  •  

Side effects other than those listed here may also occur. Contact your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect measles, mumps, and rubella vaccine?

Before receiving this vaccine, tell the doctor about all other vaccines you have recently received.

Also tell the doctor if you have recently received drugs or treatments that can weaken the immune system, including:

  • an oral, nasal, inhaled, or injectable steroid medicine;
  • medications to treat psoriasis, rheumatoid arthritis, or other autoimmune disorders, such as azathioprine (Imuran), efalizumab (Raptiva), etanercept (Enbrel), leflunomide (Arava), and others; or
  • medicines to treat or prevent organ transplant rejection, such as basiliximab (Simulect), cyclosporine (Sandimmune, Neoral, Gengraf), muromonab-CD3 (Orthoclone), mycophenolate mofetil (CellCept), sirolimus (Rapamune), or tacrolimus (Prograf).
  •  

If you are using any of these medications, you may not be able to receive the vaccine, or may need to wait until the other treatments are finished.

There may be other drugs that can affect this vaccine. Tell your doctor about all the prescription and over-the-counter medications you have received. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

 

ProQuad -Measles, Mumps, Rubella, and Varicella Vaccine

Do NOT use ProQuad if:

  • you are allergic to any ingredient in ProQuad , including gelatin
  • you have had a severe allergic reaction (eg, severe rash, hives, difficulty breathing, dizziness) to neomycin
  • you have a weakened immune system (eg, advanced HIV, AIDS, decreased gamma globulin levels, decreased white blood cell levels), blood problems, cancer affecting the blood or bone marrow (eg, leukemia), fever, or active or untreated tuberculosis (TB)
  • you are pregnant
  • you are taking an immunosuppressant (eg, cyclosporine) or a salicylate (eg, aspirin)

Contact your doctor or health care provider right away if any of these apply to you.

Before using ProQuad :

Some medical conditions may interact with ProQuad . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are planning to become pregnant or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you are allergic to eggs
  • if you have an infection, a tumor, HIV, low blood platelet levels, a history of seizures or head injury, or a family history of seizures or immune system weakness
  • if you have had a recent blood or plasma transfusion or have received immune globulin or a tuberculin test
  • if you have been exposed to measles, mumps, rubella, or chickenpox
  • if you have a history of tuberculosis

Some MEDICINES MAY INTERACT with ProQuad . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Corticosteroids (eg, prednisone) or immunosuppressants (eg, cyclosporine) because the effectiveness of ProQuad may be decreased
  • Salicylates (eg, aspirin) because the risk of side effects may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if ProQuad may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

  • ProQuad may cause drowsiness or dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to ProQuad . Using ProQuad alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
  • This medicine may decrease the effectiveness of tuberculin tests. If you are scheduled to have a tuberculin test within 6 weeks after receiving this vaccination, contact your doctor. You may need to reschedule your tuberculin test.
  • Avoid contact with individuals with weakened immune systems, pregnant women who have not had chickenpox, and newborns whose mothers have not had chickenpox for 6 weeks after receiving this vaccination.
  • Avoid use of salicylates (eg, aspirin) for 6 weeks after receiving this vaccination.
  • Keep written documentation of all vaccinations received to help avoid unnecessary doses. Be sure that your doctor knows the dates that you have received other vaccinations.
  • This vaccine may not guarantee protection against measles, mumps, rubella, or chickenpox. Discuss any questions or concerns with your doctor.
  • Adult women may experience joint pain 2 to 4 weeks after receiving this injection. This usually lasts only a short time. However, these symptoms have persisted for months or, rarely, years.
  • ProQuad contains albumin, which comes from human blood. There is an extremely rare risk of developing a viral disease, or a central nervous system disease called Creutzfeldt-Jakob disease. No cases of viral diseases or Creutzfeldt-Jakob disease from albumin have been identified.
  • Use ProQuad with extreme caution in CHILDREN younger than 12 months of age. Safety and effectiveness in this age group have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Do not use ProQuad if you are pregnant. If you suspect that you could be pregnant, contact your doctor immediately. After receiving ProQuad , do not become pregnant for at least 3 months without checking with your doctor. It is unknown if ProQuad is excreted in breast milk. Do not breast-feed while using ProQuad .

Possible side effects of ProQuad :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; dizziness; fever; general unwell feeling; headache; irritability; mild rash; muscle or joint ache or pain; nausea; pain, tenderness, soreness, or swelling at the injection site; tiredness; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); fainting; loss of coordination; mental or mood changes; numbness or tingling in the fingers or toes; red, swollen, blistered, or peeling skin; seizures; unusual bruising or bleeding; vision or hearing changes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

 

Encephalitis and Encephalopathy

 

 

Encephalitis is inflammation of the brain. The inflammation is caused either by an infection invading the brain (infectious); or through the immune system attacking the brain in error (post-infectious / autoimmune encephalitis).

Encephalitis is different from meningitis. Meningitis means inflammation of the protective layers that cover the brain. Sometimes patients have both meningitis and encephalitis and this is called meningoencephalitis.

 

Encephalopathy is a term for any diffuse disease of the brain that alters brain function or structure. Encephalopathy may be caused by infectious agent (bacteria, virus, or prion), metabolic or mitochondrial dysfunction, brain tumor or increased pressure in the skull, prolonged exposure to toxic elements (including solvents, drugs, radiation, paints, industrial chemicals, and certain metals), chronic progressive trauma, poor nutrition, or lack of oxygen or blood flow to the brain. The hallmark of encephalopathy is an altered mental state. Depending on the type and severity of encephalopathy, common neurological symptoms are progressive loss of memory and cognitive ability, subtle personality changes, inability to concentrate, lethargy, and progressive loss of consciousness. Other neurological symptoms may include myoclonus (involuntary twitching of a muscle or group of muscles), nystagmus (rapid, involuntary eye movement), tremor, muscle atrophy and weakness, dementia, seizures, and loss of ability to swallow or speak. Blood tests, spinal fluid examination, imaging studies, electroencephalograms, and similar diagnostic studies may be used to differentiate the various causes of encephalopathy.

 

 

  Pertussis vaccination and epilepsy–an erratic history, new research and the mismatch between science and social policy.

 

For over 50 years, concerns have been raised about the risk of pertussis vaccine-induced childhood encephalopathy and epilepsy. This article reviews the scientific literature, and the social and historical context in which the scientific, public health and societal views have not always been aligned. Large-scale studies of this issue have produced conflicting results, although the recent consensus is that the risk of vaccine-induced encephalopathy and/or epilepsy, if it exists at all, is extremely low. Risk estimates in the literature have included: risk of a febrile seizure 1 per 19,496 vaccinations; risk of an afebrile seizure 1 per 76,133 vaccinations; risk of encephalopathy after pertussis infection nil-3 cases per million vaccinations. A recent study showed that encephalopathy in 11 out of the 14 children studied, although previously attributed to vaccination, was in fact due an inherited genetic defect of the SCNIA gene that codes for the voltage gated neuronal sodium channel. This study is important because it provides a solid alternative explanation for the perceived pertussis vaccine-encephalopathy association. The interesting possibility is raised that the encephalopathy apparently due to pertussis itself may, in some cases, be due to an SCNIA mutation. It may also, by analogy, shed some light on the continuing debate about other serious long-term adverse effects of vaccination in general.

 

 To be continued…the autism connection, post-vaccinal encephalomyelitis, the rise in neurological disorders…